Publications
194 results found
Jayasena CN, Nijher GMK, Narayanaswamy S, et al., 2014, Age-dependent elevations in plasma kisspeptin are observed in boys and girls when compared with adults, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 51, Pages: 89-96, ISSN: 0004-5632
Jayasena CN, Comninos AN, De Silva A, et al., 2014, Effects of Neurokinin B Administration on Reproductive Hormone Secretion in Healthy Men and Women, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 99, Pages: E19-E27, ISSN: 0021-972X
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- Citations: 30
Jayasena CN, Comninos AN, Nijher GMK, et al., 2013, Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: 4464-4474, ISSN: 0021-972X
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- Citations: 22
Jayasena CN, Dhillo WS, 2013, Carcinoid syndrome and neuroendocrine tumours, Medicine (United Kingdom), Vol: 41, Pages: 566-569, ISSN: 1357-3039
Gut neuroendocrine tumours (NETs) arise from the gastrointestinal tract or pancreas and comprise a variety of different tumour types. Carcinoid tumours are the most common type of neuroendocrine tumour. NETs may be associated with a variety of clinical syndromes. For instance, classic symptoms of carcinoid syndrome, such as flushing and diarrhoea, occur as a consequence of the release of hormones, including serotonin, tachykinins and peptide hormones. However, the majority of NETs are not secretory in nature and are detected incidentally or through compression of surrounding structures. In the majority of cases, liver metastasis has already occurred at the time of diagnosis. However, surgery can be curative if disease is entirely localized. Somatostatin analogue injections such as octreotide are the mainstay of non-surgical treatment for NETs. Surgical debulking and embolization techniques are useful methods to reduce tumour bulk in patients who remain symptomatic despite medical treatment. Peptide receptor radionucleotide therapy using radiolabelled somatostatin analogues is becoming increasingly available. Furthermore, a number of novel agents such as everolimus have emerged in the treatment of patients with metastatic disease. This article aims to summarize the pathophysiology and clinical features of NETs, with a focus on carcinoid syndrome. It will also discuss recent advances in clinical management of NETs. © 2013 Elsevier Ltd. All rights reserved.
Jayasena CN, Comninos AN, Veldhuis JD, et al., 2013, A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women, CLINICAL ENDOCRINOLOGY, Vol: 79, Pages: 558-563, ISSN: 0300-0664
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- Citations: 37
Jayasena CN, Modi M, Palazzo F, et al., 2013, Associations of serum 25-hydroxyvitamin D with circulating PTH, phosphate and calcium in patients with primary hyperparathyroidism, CLINICAL ENDOCRINOLOGY, Vol: 78, Pages: 838-843, ISSN: 0300-0664
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- Citations: 8
Comninos AN, Jayasena CN, Nijher GMK, et al., 2013, Chronic kisspeptin administration advances the menstrual cycle in healthy women, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 334-335, ISSN: 0268-1161
Jayasena CN, Abbara A, Comninos AN, et al., 2013, Kisspeptin-54 administration stimulates pulsatile luteinising hormone secretion in women with hypothalamic amenorrhea, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 110-110, ISSN: 0268-1161
Beale KEL, Gardiner JV, Bewick GA, et al., 2013, Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 168, Pages: 403-410, ISSN: 0007-1188
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- Citations: 26
Abbara A, Ratnasabapathy R, Jayasena CN, et al., 2013, The Effects of Kisspeptin on Gonadotropin Release in Non-human Mammals, KISSPEPTIN SIGNALING IN REPRODUCTIVE BIOLOGY, Vol: 784, Pages: 63-87, ISSN: 0065-2598
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- Citations: 24
Suzuki K, Jayasena CN, Bloom SR, 2012, Obesity and Appetite Control, Experimental Diabetes Research, Vol: 2012, ISSN: 1687-5214
Jayasena CN, Comninos AN, Januszewski A, et al., 2012, Plasma Kisspeptin: A Potential Biomarker of Tumor Metastasis in Patients with Ovarian Carcinoma, CLINICAL CHEMISTRY, Vol: 58, Pages: 1061-1063, ISSN: 0009-9147
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- Citations: 12
Dhillo WS, 2012, The relationship between gut and adipose hormones and reproduction, HUMAN REPRODUCTION, Vol: 27, ISSN: 0268-1161
Jayasena CN, Nijher GMK, Comninos AN, et al., 2011, The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 96, Pages: E1963-E1972, ISSN: 0021-972X
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- Citations: 89
Jayasena CN, Comninos AN, Clarke H, et al., 2011, The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly, CLINICAL ENDOCRINOLOGY, Vol: 75, Pages: 220-225, ISSN: 0300-0664
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- Citations: 44
Jayasena CN, Mahmud M, Palazzo F, et al., 2011, Utility of the urine calcium-to-creatinine ratio to diagnose primary hyperparathyroidism in asymptomatic hypercalcaemic patients with vitamin D deficiency, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 48, Pages: 126-129, ISSN: 0004-5632
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- Citations: 19
Hameed S, Jayasena CN, Dhillo WS, 2011, Kisspeptin and fertility, JOURNAL OF ENDOCRINOLOGY, Vol: 208, Pages: 97-105, ISSN: 0022-0795
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- Citations: 47
Suzuki K, Jayasena CN, Bloom SR, 2011, The gut hormones in appetite regulation., J Obes, Vol: 2011
Obesity has received much attention worldwide in association with an increased risk of cardiovascular diseases, diabetes, and cancer. At present, bariatric surgery is the only effective treatment for obesity in which long-term weight loss is achieved in patients. By contrast, pharmacological interventions for obesity are usually followed by weight regain. Although the exact mechanisms of long-term weight loss following bariatric surgery are yet to be fully elucidated, several gut hormones have been implicated. Gut hormones play a critical role in relaying signals of nutritional and energy status from the gut to the central nervous system, in order to regulate food intake. Cholecystokinin, peptide YY, pancreatic polypeptide, glucagon-like peptide-1, and oxyntomodulin act through distinct yet synergistic mechanisms to suppress appetite, whereas ghrelin stimulates food intake. Here, we discuss the role of gut hormones in the regulation of food intake and body weight.
Jayasena CN, Nijher GMK, Abbara A, et al., 2010, Twice-Weekly Administration of Kisspeptin-54 for 8 Weeks Stimulates Release of Reproductive Hormones in Women With Hypothalamic Amenorrhea, CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol: 88, Pages: 840-847, ISSN: 0009-9236
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- Citations: 82
Jayasena CN, Dhillo WS, 2010, Neurokinin B and Kisspeptin: Sexual Partners or Single Agents?, ENDOCRINOLOGY, Vol: 151, Pages: 4090-4091, ISSN: 0013-7227
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- Citations: 3
Nijher GMK, Baxter JE, Chaudhri OB, et al., 2010, Identification of the Hormone Kisspeptin in Amniotic Fluid, CLINICAL CHEMISTRY, Vol: 56, Pages: 1029-1031, ISSN: 0009-9147
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- Citations: 3
Jayasena CN, Nijher GMK, Chaudhri OB, et al., 2010, Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis, Obstetrical and Gynecological Survey, Vol: 65, Pages: 244-245, ISSN: 0029-7828
Logan S, Jayasena C, Aali A, et al., 2010, Typhoid without travel, Clinical Medicine, Vol: 10, Pages: 299-300
Jayasena CN, Nijher GMK, Chaudhri OB, et al., 2009, Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 94, Pages: 4315-4323, ISSN: 0021-972X
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- Citations: 150
Bloom S, 2009, Gut hormones and appetite regulation, Joint Meeting of the European-Neuropeptides-Club/Summer Neuropeptides Conference, Publisher: CHURCHILL LIVINGSTONE, Pages: 437-438, ISSN: 0143-4179
Jayasena CN, Dhillo WS, 2009, Carcinoid syndrome, Medicine, Vol: 37, Pages: 454-456, ISSN: 1357-3039
Carcinoid tumours are the most common type of neuroendocrine tumour. However, fewer than 10% actually lead to carcinoid syndrome. Carcinoid tumours arise from enterochromaffin and enterochromaffin-like cells, which originate from the primitive gut. Classic symptoms of carcinoid syndrome, such as flushing and diarrhoea, occur as a consequence of the release of hormones, including serotonin, tachykinins and peptide hormones. In the majority of cases, liver metastasis has already occurred at the time of diagnosis. The diagnosis of carcinoid syndrome is made biochemically. Raised levels of a serotonin metabolite, 5-hydroxyindoleacetic acid, are detected during 24-hour urine collection. In addition, raised plasma chromogranin A is supportive of the diagnosis, but is not specific to carcinoid syndrome itself. Somatostatin analogue injections such as octreotide are the mainstay of carcinoid syndrome treatment. Simple therapies such as loperamide and antihistamines may also help to alleviate symptoms. Surgical debulking and hepatic embolization are useful methods to reduce tumour bulk in patients who remain symptomatic on medical treatment. Radioisotope therapy using radiolabelled octreotide or radiolabelled 5-hydroxytryptophan is becoming increasingly available, but is still used in only a minority of cases. A review of the pathophysiology and clinical features of carcinoid syndrome is provided and important issues in its management are highlighted. © 2009 Elsevier Ltd. All rights reserved.
Jayasena CN, Tharakan G, Dhillo WS, 2009, Kisspeptin: paving the way to a new therapeutic avenue in reproduction, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, Vol: 3, Pages: 87-93
Jayasena CN, Gadhvi KA, Gohel B, et al., 2009, Day 5 Morning Serum Cortisol Predicts Hypothalamic-Pituitary-Adrenal Function after Transsphenoidal Surgery for Pituitary Tumors, CLINICAL CHEMISTRY, Vol: 55, Pages: 972-977, ISSN: 0009-9147
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- Citations: 35
Jayasena CN, Dhillo WS, 2009, Kisspeptin offers a novel therapeutic target in reproduction, CURRENT OPINION IN INVESTIGATIONAL DRUGS, Vol: 10, Pages: 311-318, ISSN: 1472-4472
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- Citations: 12
Jayasena CN, Dhillo WS, Bloom SR, 2009, Kisspeptins and the control of gonadotropin secretion in humans, PEPTIDES, Vol: 30, Pages: 76-82, ISSN: 0196-9781
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- Citations: 12
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