Imperial College London
Alternate

Dr. Channa Jayasena MA PhD MRCP FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Reproductive Endocrinology
 
 
 
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Contact

 

c.jayasena Website

 
 
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Location

 

6N5CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jayasena:2015:humrep/dev143,
author = {Jayasena, CN and Abbara, A and Narayanaswamy, S and Comninos, AN and Ratnasabapathy, R and Bassett, P and Mogford, JT and Malik, Z and Calley, J and Ghatei, MA and Bloom, SR and Dhillo, WS},
doi = {humrep/dev143},
journal = {Human Reproduction},
pages = {1934--1941},
title = {Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men},
url = {http://dx.doi.org/10.1093/humrep/dev143},
volume = {30},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - study question: How potently does the novel hypothalamic stimulator of reproduction, kisspeptin, increase gonadotrophin secretionwhen compared with GnRH in healthy men?summaryanswer: At the doses tested, intravenous administration of either of two major kisspeptin isoforms, kisspeptin-10 and -54, wasassociated with similar levels of gonadotrophin secretion in healthy men; however, GnRH was more potent when compared with either kisspeptinisoform.what is known already: Kisspeptin-10 and -54 are naturally occurring hormones in the kisspeptin peptide family which potently stimulatesendogenous GnRH secretion from the hypothalamus, so have the potential to treat patients with reproductive disorders. Rodent studiessuggest that kisspeptin-54 is more potent when compared with kisspepitn-10; however, their effects have not previously been directly comparedin humans, or compared with direct pituitary stimulation of gonadotrophin secretion using GnRH.study design, size and duration: A single-blinded placebo controlled physiological study was performed from January to December2013. Local ethical approval was granted, and five participants were recruited to each dosing group.participants/materials, setting, methods: Healthy men were administered vehicle, kisspeptin-10, kisspeptin-54 andGnRH intravenously for 3 h on different study days. Each hormone was administered at 0.1, 0.3 and 1.0 nmol/kg/h doses (n ¼ 5 subjects pergroup). Regular blood sampling was conducted throughout the study to measure LH and FSH. Study visits were conducted at least a week apart.main results and the role of chance: Serum LH and FSH levels were 3-fold higher during GnRH infusion when comparedwith kisspeptin-10 and 2-fold higher when compared with kisspeptin-54 [mean area under the curve serum LH during infusion (in hours timesinternational units per litre, h.IU/l): 10.81+1.73, 1.0 nmol/kg/h kisspeptin-10; 14.43+1.27, 1.0 nmol/kg/h kisspeptin-54; 34.06+5.18,1.0 nmol/kg/h GnRH, P , 0.001 versus kis
AU  - Jayasena,CN
AU  - Abbara,A
AU  - Narayanaswamy,S
AU  - Comninos,AN
AU  - Ratnasabapathy,R
AU  - Bassett,P
AU  - Mogford,JT
AU  - Malik,Z
AU  - Calley,J
AU  - Ghatei,MA
AU  - Bloom,SR
AU  - Dhillo,WS
DO  - humrep/dev143
EP  - 1941
PY  - 2015///
SN  - 1460-2350
SP  - 1934
TI  - Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men
T2  - Human Reproduction
UR  - http://dx.doi.org/10.1093/humrep/dev143
UR  - http://hdl.handle.net/10044/1/23309
VL  - 30
ER  -
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