Imperial College London
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Professor Christoph Lees, MD FRCOG

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Obstetrics
 
 
 
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Contact

 

+44 (0)20 7594 5770c.lees

 
 
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Assistant

 

Ms Hazel Blackman +44 (0)20 7594 2104

 
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Location

 

Queen Charlottes and Chelsea HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jessop:2016:10.1007/s00428-015-1899-0,
author = {Jessop, FA and Lees, CC and Pathak, S and Hook, CE and Sebire, NJ},
doi = {10.1007/s00428-015-1899-0},
journal = {Virchows Archiv},
pages = {503--507},
title = {Funisitis is associated with adverse neonatal outcome in low-risk unselected deliveries at or near term},
url = {http://dx.doi.org/10.1007/s00428-015-1899-0},
volume = {468},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This study aimed to determine the incidence and clinical outcomes for varying patterns of placental histological inflammation (consistent with fetal or maternal inflammatory response) in an unselected population of >1000 women with a singleton pregnancy resulting in live birth delivering at or near term. One thousand one hundred nineteen cases were studied in a blind, prospective, unselected study with placentas categorized into five histological subgroups reflecting underlying maternal or fetal inflammatory response. Clinical outcomes studied included interventional delivery, an Apgar score <7 at 1 min, neonatal acidosis (pH < 7.2) and admission to neonatal special care. One hundred eighty-eight placentas (17 %) showed histological evidence of acute inflammation: 64 with funisitis (with or without other inflammation; 6 %); 16 with extensive acute inflammation across the chorionic plate, free membranes and subchorionic fibrin (1 %); 28 with acute inflammation restricted to the chorionic plate (2 %); 12 with acute inflammation restricted to the free membranes (1 %) and 68 with acute inflammation restricted to the subchorionic fibrin (6 %). Features of extensive acute inflammation were significantly associated with increased rate of interventional delivery (assisted vaginal delivery or emergency caesarean section; P < 0.01). The presence of funisitis was significantly associated with interventional delivery and other adverse outcomes including an Apgar score <7 at 1 min, clinical evidence of sepsis and admission to the neonatal intensive care unit (P < 0.05 for all). The data represent a quantitative rather than purely qualitative analysis of the contribution of histological lesions related to inflammation on short-term adverse neonatal outcomes and interventional delivery. Funisitis and extensive inflammation are associated with adverse clinical outcomes, but the precise mechanism underlying these remains to
AU  - Jessop,FA
AU  - Lees,CC
AU  - Pathak,S
AU  - Hook,CE
AU  - Sebire,NJ
DO  - 10.1007/s00428-015-1899-0
EP  - 507
PY  - 2016///
SN  - 1432-2307
SP  - 503
TI  - Funisitis is associated with adverse neonatal outcome in low-risk unselected deliveries at or near term
T2  - Virchows Archiv
UR  - http://dx.doi.org/10.1007/s00428-015-1899-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000374312900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/34678
VL  - 468
ER  -
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