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@article{Zwi:2020:10.1002/adma.201904598,
author = {Zwi, Dantsis L and Wang, B and Marijon, C and Zonetti, S and Ferrini, A and Massi, L and Stuckey, DJ and Terracciano, C and Stevens, M},
doi = {10.1002/adma.201904598},
journal = {Advanced Materials},
pages = {1--6},
title = {Remote magnetic nanoparticle manipulation enables the dynamic patterning of cardiac tissues},
url = {http://dx.doi.org/10.1002/adma.201904598},
volume = {32},
year = {2020}
}

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TY  - JOUR
AB  - The ability to manipulate cellular organization within soft materials has important potential in biomedicine  and  regenerative  medicine;  however,  it  often  requires  complex  fabrication procedures. Here, we develop a simple, cost-effective, and one-step approach that enables the control of cell orientation within 3-dimensional (3D) collagen hydrogels to dynamically create various tailored microstructures of cardiac tissues. This isachieved by incorporating iron-oxide nanoparticles into human cardiomyocytes (CMs) and applying a short-term external magnetic field to orient the cells along the applied field to impart different shapes without any mechanical supports. The patterned constructs areviable and functional, canbe detected by T2-weighted MRI  and  induceno  alteration  to  normal  cardiac  function  after  grafting  onto  rat  hearts.  This strategy paves the way to creating customized, macroscale, 3D tissue constructs with various cell-types  for  therapeutic  and  bioengineering  applications,  as  well  as  providing  powerful models for investigating tissue behavior.
AU  - Zwi,Dantsis L
AU  - Wang,B
AU  - Marijon,C
AU  - Zonetti,S
AU  - Ferrini,A
AU  - Massi,L
AU  - Stuckey,DJ
AU  - Terracciano,C
AU  - Stevens,M
DO  - 10.1002/adma.201904598
EP  - 6
PY  - 2020///
SN  - 0935-9648
SP  - 1
TI  - Remote magnetic nanoparticle manipulation enables the dynamic patterning of cardiac tissues
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.201904598
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201904598
UR  - http://hdl.handle.net/10044/1/75337
VL  - 32
ER  -

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