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@article{Kontoravdi:2012,
author = {Kontoravdi, C},
journal = {The Bentham Science Newsletter},
title = {From Systems Biology to Systems Medicine},
url = {http://www.benthamscience.com/bensci/Volume4-2/manuscriptp1.html},
volume = {4},
year = {2012}
}

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TY  - JOUR
AB  - Systems biology is an established research field that seeks to integrate experimentation with computational approaches to improve our understanding of biological systems. In recent years it has been argued that the principles of this holistic approach are equally applicable to medical problems, where the biological system is perturbed from its native state. Systems medicine can help integrate disparate datasets, interpret the effect of mutations, and therefore identify opportunities for tailored approaches to treatment. In this work, we have focused on the unfolded protein response, a signalling cascade originating in the endoplasmic reticulum, which has been studied experimentally and computationally in the context of Bioprocessing. However, it is equally important in neurodegenerative diseases as its markers have been found to be upregulated in tissue samples from patients suffering from Alzheimer’s, Parkinson’s and Huntington’s disease. We have used an existing model for protein folding in the endoplasmic reticulum to examine how the accumulation of unfolded proteins can be relieved and have further conducted a sensitivity analysis to identify the rate-limiting steps in protein folding. Our results highlight the crucial role of protein disulfide-isomerase in protein processing in the organelle.
AU  - Kontoravdi,C
PY  - 2012///
TI  - From Systems Biology to Systems Medicine
T2  - The Bentham Science Newsletter
UR  - http://www.benthamscience.com/bensci/Volume4-2/manuscriptp1.html
VL  - 4
ER  -

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Professor Cleo Kontoravdi

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