Imperial College London
Alternate

ProfessorDavidDexter

Faculty of Medicine, Department of Brain Sciences

Visiting Professor of Neuropharmacology
 
 
 
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Contact

 

+44 (0)20 7594 6665d.dexter Website

 
 
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Location

 

E411Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ward:2015:10.2741/433,
author = {Ward, RJ and Dexter, DT and Crichton, RR},
doi = {10.2741/433},
journal = {Frontiers in Bioscience - Scholar},
pages = {189--204},
title = {Ageing, neuroinflammation and neurodegeneration},
url = {http://dx.doi.org/10.2741/433},
volume = {7},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - During ageing, different iron complexes accumulate in specific brain regions which are associated with motor and cognitive dysfunction. In neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, changes in local iron homoeostasis result in altered cellular iron distribution and accumulation, ultimately inducing neurotoxicity. The use of iron chelators which are able to penetrate the blood brain barrier and reduce excessive iron accumulation in specific brain regions have been shown to reduce disease progression in both Parkinson's disease and Friedreich's Ataxia. Neuroinflammation often occurs in neurodegenerative diseases, which is mainly sustained by activated microglia exhibiting the M1 phenotype. Such inflammation contributes to the disease progression. Therapeutic agents which reduce such inflammation, e.g. taurine compounds, may ameliorate the inflammatory process by switching the microglia from a M1 to a M2 phenotype.
AU  - Ward,RJ
AU  - Dexter,DT
AU  - Crichton,RR
DO  - 10.2741/433
EP  - 204
PY  - 2015///
SN  - 1945-0524
SP  - 189
TI  - Ageing, neuroinflammation and neurodegeneration
T2  - Frontiers in Bioscience - Scholar
UR  - http://dx.doi.org/10.2741/433
VL  - 7
ER  -
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