Imperial College London
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ProfessorDarioFarina

Faculty of Engineering, Department of Bioengineering

Chair in Neurorehabilitation Engineering
 
 
 
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Contact

 

+44 (0)20 7594 1387d.farina Website

 
 
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Location

 

RSM 4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pascual:2020:10.1109/TBME.2020.3015572,
author = {Pascual, Valdunciel A and Gonzalez-Sanchez, M and Muceli, S and Adan-Barrientos, B and Escobar-Segura, V and Perez-Sanchez, JR and Jung, MK and Schneider, A and Hoffmann, K-P and Moreno, JC and Grandas, F and Farina, D and Jose, P and Barroso, F},
doi = {10.1109/TBME.2020.3015572},
journal = {IEEE Transactions on Biomedical Engineering},
title = {Intramuscular stimulation of muscle afferents attains prolonged tremor reduction in essential tremor patients.},
url = {http://dx.doi.org/10.1109/TBME.2020.3015572},
volume = {PP},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This study proposes and clinically tests intramuscular electrical stimulation below motor threshold to achieve prolonged reduction of wrist flexion/extension tremor in Essential Tremor (ET) patients. The developed system consisted of an intramuscular thin-film electrode structure that included both stimulation and electromyography (EMG) recording electrodes, and a control algorithm for the timing of intramuscular stimulation based on EMG (closed-loop stimulation). Data were recorded from nine ET patients with wrist flexion/extension tremor recruited from the Gregorio Maran Hospital (Madrid, Spain). Patients participated in two experimental sessions comprising: 1) sensory stimulation of wrist flexors/extensors via thin-film multichannel intramuscular electrodes; and 2) surface stimulation of the nerves innervating the same target muscles. For each session, four of these patients underwent random 60-s trials of two stimulation strategies for each target muscle: 1) selective and adaptive timely stimulation (SATS) - based on EMG of the antagonist muscle; and 2) continuous stimulation (CON) of target muscles. Two patients underwent SATS stimulation trials alone while the other three underwent CON stimulation trials alone in each session. Kinematics of wrist, elbow, and shoulder, together with clinical scales, were used to assess tremor before, right after, and 24 h after each session. Intramuscular SATS achieved, on average, 32% acute (during stimulation) tremor reduction on each trial, while continuous stimulation augmented tremorgenic activity. Furthermore, tremor reduction was significantly higher using intramuscular than surface stimulation. Prolonged reduction of tremor amplitude (24 h after the experiment) was observed in four patients. These results showed acute and prolonged (24 h) tremor reduction using a minimally invasive neurostimulation technology based on SATS of primary sensory afferents of wrist muscles. This strategy might open the possibility of an alte
AU  - Pascual,Valdunciel A
AU  - Gonzalez-Sanchez,M
AU  - Muceli,S
AU  - Adan-Barrientos,B
AU  - Escobar-Segura,V
AU  - Perez-Sanchez,JR
AU  - Jung,MK
AU  - Schneider,A
AU  - Hoffmann,K-P
AU  - Moreno,JC
AU  - Grandas,F
AU  - Farina,D
AU  - Jose,P
AU  - Barroso,F
DO  - 10.1109/TBME.2020.3015572
PY  - 2020///
SN  - 0018-9294
TI  - Intramuscular stimulation of muscle afferents attains prolonged tremor reduction in essential tremor patients.
T2  - IEEE Transactions on Biomedical Engineering
UR  - http://dx.doi.org/10.1109/TBME.2020.3015572
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32813648
UR  - https://ieeexplore.ieee.org/document/9171555
UR  - http://hdl.handle.net/10044/1/82397
VL  - PP
ER  -
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