Imperial College London
Portrait Picture

ProfessorDarioFarina

Faculty of Engineering, Department of Bioengineering

Chair in Neurorehabilitation Engineering
 
 
 
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Contact

 

+44 (0)20 7594 1387d.farina Website

 
 
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Location

 

RSM 4.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sartori:2016:10.1002/wsbm.1368,
author = {Sartori, M and Fernandez, JW and Modenese, L and Carty, CP and Barber, LA and Oberhofer, K and Zhang, J and Handsfield, GG and Stott, NS and Besier, TF and Farina, D and Lloyd, DG},
doi = {10.1002/wsbm.1368},
journal = {WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE},
title = {Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy},
url = {http://dx.doi.org/10.1002/wsbm.1368},
volume = {9},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This position paper proposes a modeling pipeline to develop clinically relevant neuromusculoskeletal models to understand and treat complex neurological disorders. Although applicable to a variety of neurological conditions, we provide direct pipeline applicative examples in the context of cerebral palsy (CP). This paper highlights technologies in: (1) patient-specific segmental rigid body models developed from magnetic resonance imaging for use in inverse kinematics and inverse dynamics pipelines; (2) efficient population-based approaches to derive skeletal models and muscle origins/insertions that are useful for population statistics and consistent creation of continuum models; (3) continuum muscle descriptions to account for complex muscle architecture including spatially varying material properties with muscle wrapping; (4) muscle and tendon properties specific to CP; and (5) neural-based electromyography-informed methods for muscle force prediction. This represents a novel modeling pipeline that couples for the first time electromyography extracted features of disrupted neuromuscular behavior with advanced numerical methods for modeling CP-specific musculoskeletal morphology and function. The translation of such pipeline to the clinical level will provide a new class of biomarkers that objectively describe the neuromusculoskeletal determinants of pathological locomotion and complement current clinical assessment techniques, which often rely on subjective judgment.
AU  - Sartori,M
AU  - Fernandez,JW
AU  - Modenese,L
AU  - Carty,CP
AU  - Barber,LA
AU  - Oberhofer,K
AU  - Zhang,J
AU  - Handsfield,GG
AU  - Stott,NS
AU  - Besier,TF
AU  - Farina,D
AU  - Lloyd,DG
DO  - 10.1002/wsbm.1368
PY  - 2016///
SN  - 1939-5094
TI  - Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy
T2  - WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
UR  - http://dx.doi.org/10.1002/wsbm.1368
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394898500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48153
VL  - 9
ER  -
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