Imperial College London
Alternate

Professor Daqing Ma, MD, PhD

Faculty of Medicine, Department of Surgery & Cancer

Professor of Anaesthesia
 
 
 
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Contact

 

+44 (0)20 3315 8495d.ma Website

 
 
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Assistant

 

Miss Steffi Klier +44 (0)20 3315 8816

 
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Location

 

G3.44Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhao:2015:10.1038/cddis.2015.316,
author = {Zhao, H and Jaffer, T and Eguchi, S and Wang, Z and Linkermann, A and Ma, D},
doi = {10.1038/cddis.2015.316},
journal = {Cell Death & Disease},
title = {Role of necroptosis in the pathogenesis of solid organ injury},
url = {http://dx.doi.org/10.1038/cddis.2015.316},
volume = {6},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase independent. Increasing evidence has implicated necroptosis in the pathogenesis of disease, including ischemic injury, neurodegeneration, viral infection and many others. Key players of the necroptosis signalling pathway are now widely recognized as therapeutic targets. Necrostatins may be developed as potent inhibitors of necroptosis, targeting the activity of RIPK1. Necrostatin-1, the first generation of necrostatins, has been shown to confer potent protective effects in different animal models. This review will summarize novel insights into the involvement of necroptosis in specific injury of different organs, and the therapeutic platform that it provides for treatment.
AU  - Zhao,H
AU  - Jaffer,T
AU  - Eguchi,S
AU  - Wang,Z
AU  - Linkermann,A
AU  - Ma,D
DO  - 10.1038/cddis.2015.316
PY  - 2015///
SN  - 2041-4889
TI  - Role of necroptosis in the pathogenesis of solid organ injury
T2  - Cell Death & Disease
UR  - http://dx.doi.org/10.1038/cddis.2015.316
UR  - http://hdl.handle.net/10044/1/27762
VL  - 6
ER  -
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