Imperial College London
Professor Dominic Withers

ProfessorDominicWithers

Faculty of Medicine, Institute of Clinical Sciences

Clinical Chair in Diabetes & Endocrinology
 
 
 
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Contact

 

d.withers

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

127 results found

Partridge L, Gems D, Withers DJ, 2005, Sex and death: What is the connection?, CELL, Vol: 120, Pages: 461-472, ISSN: 0092-8674

Journal article

Broughton SJ, Piper MDW, Ikeya T, Bass TM, Jacobson J, Driege Y, Martinez P, Hafen E, Withers DJ, Leevers SJ, Partridge Let al., 2005, Longer lifespan, altered metabolism, and stress resistance in <i>Drosophila</i> from ablation of cells making insulin-like ligands, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 3105-3110, ISSN: 0027-8424

Journal article

Bedford DC, Simmgen M, Withers DJ, 2004, Combined deficiency of leptin and IRS2 leads to beta-cell failure and diabetes but not obesity, 64th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A343-A343, ISSN: 0012-1797

Conference paper

Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SRet al., 2003, Inhibition of food intake in obese subjects by peptide YY3-36, New England Journal of Medicine, Vol: 349, Pages: 941-948, ISSN: 0028-4793

Journal article

Smith DM, Coppock HA, Withers DJ, Owji AA, Hay DL, Choksi TP, Chakravarty P, Legon S, Poyner DRet al., 2002, Adrenomedullin: receptor and signal transduction, Colloquium on Lessons from the Type II Family of G-Protein-Coupled Receptores - Their Ligands, Receptor Structure and Function, Publisher: PORTLAND PRESS, Pages: 432-437, ISSN: 0300-5127

Conference paper

Wurster AL, Withers DJ, Uchida T, White MF, Grusby MJet al., 2002, Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis, MOLECULAR AND CELLULAR BIOLOGY, Vol: 22, Pages: 117-126, ISSN: 0270-7306

Journal article

Withers DJ, 2001, Insulin receptor substrate proteins and neuroendocrine function, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 29, Pages: 525-529, ISSN: 0300-5127

Journal article

Previs SF, Withers DJ, Ren JM, White MF, Shulman GIet al., 2000, Contrasting effects of IRS-1 <i>versus</i> IRS-2 gene disruption on carbohydrate and lipid metabolism <i>in vivo</i>, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 275, Pages: 38990-38994, ISSN: 0021-9258

Journal article

Burks DJ, de Mora JF, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MFet al., 2000, IRS-2 pathways integrate female reproduction and energy homeostasis, NATURE, Vol: 407, Pages: 377-382, ISSN: 0028-0836

Journal article

Withers DJ, White M, 2000, Perspective: The Insulin Signaling System-A Common Link in the Pathogenesis of Type 2 Diabetes., Endocrinology, Vol: 141, Pages: 1917-1921

Journal article

Withers DJ, White M, 2000, Perspective: The insulin signaling system - A common link in the pathogenesis of type 2 diabetes, ENDOCRINOLOGY, Vol: 141, Pages: 1917-1921, ISSN: 0013-7227

Journal article

Burks DJ, Withers DJ, Towery HH, Flint CL, Altamuro SL, White MFet al., 2000, Rosiglitazone modulates glucose metabolism in IRS-2 knockout mice, Publisher: AMER DIABETES ASSOC, Pages: A279-A279, ISSN: 0012-1797

Conference paper

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili Det al., 2000, Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2, JOURNAL OF CLINICAL INVESTIGATION, Vol: 105, Pages: 199-205, ISSN: 0021-9738

Journal article

Navé BT, Ouwens DM, Withers DJ, Alessi DR, Shepherd PRet al., 1999, Mammalian target of rapamycin is a direct target for protein kinase B:: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation, BIOCHEMICAL JOURNAL, Vol: 344, Pages: 427-431, ISSN: 0264-6021

Journal article

Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MEet al., 1999, Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling, NATURE GENETICS, Vol: 23, Pages: 32-40, ISSN: 1061-4036

Journal article

Higaki Y, Wojtaszewski JFP, Hirshman MF, Withers DJ, Towery H, White MF, Goodyear LJet al., 1999, Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 274, Pages: 20791-20795, ISSN: 0021-9258

Journal article

Smith J, Burks DJ, Peroni O, Withers DJ, Altamuro S, Myers MG, Lanner C, Depaoli-Roach A, Kahn BB, White MFet al., 1999, Adipocyte function in IRS2<SUP>-/-</SUP> mice, Publisher: AMER DIABETES ASSOC, Pages: A219-A219, ISSN: 0012-1797

Conference paper

Bonner-Weir S, Withers DJ, Weir GC, Jonas JCet al., 1999, Impaired survival of differentiating β cells but no insulin secretory defects result from ablation of IRS-2, Publisher: AMER DIABETES ASSOC, Pages: A3-A3, ISSN: 0012-1797

Conference paper

Kido Y, Kanno H, Withers DJ, Burks DJ, Accili Det al., 1999, Interaction between insulin receptor and IRS proteins in IR/IRS-<SUP>1+/-</SUP> and IR/IRS-<SUP>2+/-</SUP> mice, Publisher: AMER DIABETES ASSOC, Pages: A10-A10, ISSN: 0012-1797

Conference paper

Withers DJ, Burks DJ, Towery H, Altamuro S, White MFet al., 1999, Distinct roles of insulin receptor substrates 1 and 2 in beta cell function and carbohydrate metabolism, Publisher: AMER DIABETES ASSOC, Pages: A24-A24, ISSN: 0012-1797

Conference paper

Higaki Y, Wojtaszewski JF, Hirshman MF, Withers DJ, Towery H, White MF, Goodyear LJet al., 1999, IRS-2 in muscle is not necessary for insulin- and exercise-stimulated glucose transport, Publisher: AMER DIABETES ASSOC, Pages: A65-A65, ISSN: 0012-1797

Conference paper

Shepherd PR, Withers DJ, Siddle K, 1998, Phosphoinositide 3-kinase: the key switch in insulin signalling (vol 333, pg 471, 1998), BIOCHEMICAL JOURNAL, Vol: 335, Pages: 711-711, ISSN: 0264-6021

Journal article

Shepherd PR, Withers DJ, Siddle K, 1998, Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling, BIOCHEMICAL JOURNAL, Vol: 333, Pages: 471-490, ISSN: 0264-6021

Journal article

Withers DJ, Burks DJ, Gutierrez JS, Towery H, White MFet al., 1998, Dysregulation of insulin-stimulated PI-3 kinase activation in the liver and muscle of IRS-2 knockout mice, Publisher: AMER DIABETES ASSOC, Pages: A35-A35, ISSN: 0012-1797

Conference paper

Gutierrez JS, Withers DJ, Towery H, Burks DJ, Ren JM, Previs S, Shulman GI, Bonner-Weir S, White MFet al., 1998, Disruption of IRS-2 causes type 2 diabetes in mice, Publisher: AMER DIABETES ASSOC, Pages: A57-A57, ISSN: 0012-1797

Conference paper

Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang YT, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MFet al., 1998, Disruption of IRS-2 causes type 2 diabetes in mice, NATURE, Vol: 391, Pages: 900-904, ISSN: 0028-0836

Journal article

Withers DJ, Ouwens DM, Nave BT, van der Zon GCM, Alarcon CM, Cardenas ME, Heitman J, Maassen JA, Shepherd PRet al., 1997, Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 241, Pages: 704-709, ISSN: 0006-291X

Journal article

Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ, Bloom SRet al., 1997, Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice, JOURNAL OF CLINICAL INVESTIGATION, Vol: 100, Pages: 2729-2736, ISSN: 0021-9738

Journal article

Withers DJ, 1997, Signalling pathways involved in the mitogenic effects of cAMP, CLINICAL SCIENCE, Vol: 92, Pages: 445-451, ISSN: 0143-5221

Journal article

Hammond PJ, KhandanNia N, Withers DJ, Jones PM, Ghatei MA, Bloom SRet al., 1997, Regulation of anterior pituitary galanin and vasoactive intestinal peptide by oestrogen and prolactin status, JOURNAL OF ENDOCRINOLOGY, Vol: 152, Pages: 211-219, ISSN: 0022-0795

Journal article

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