Publications
1046 results found
CHOLLET F, DIPIERO V, WISE RJS, et al., 1991, THE FUNCTIONAL-ANATOMY OF MOTOR RECOVERY AFTER STROKE IN HUMANS - A STUDY WITH POSITRON EMISSION TOMOGRAPHY, ANNALS OF NEUROLOGY, Vol: 29, Pages: 63-71, ISSN: 0364-5134
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- Citations: 889
BROOKS DJ, 1991, PET - ITS CLINICAL ROLE IN NEUROLOGY, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 54, Pages: 1-5, ISSN: 0022-3050
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- Citations: 20
BROOKS DJ, 1991, THE CLINICAL ROLE OF PET IN CEREBROVASCULAR-DISEASE, NEUROSURGICAL REVIEW, Vol: 14, Pages: 91-96, ISSN: 0344-5607
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- Citations: 7
SAWLE GV, COLEBATCH JG, SHAH A, et al., 1990, STRIATAL FUNCTION IN NORMAL AGING - IMPLICATIONS FOR PARKINSONS-DISEASE, ANNALS OF NEUROLOGY, Vol: 28, Pages: 799-804, ISSN: 0364-5134
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- Citations: 154
LEENDERS KL, SALMON EP, TYRRELL P, et al., 1990, THE NIGROSTRIATAL DOPAMINERGIC SYSTEM ASSESSED INVIVO BY POSITRON EMISSION TOMOGRAPHY IN HEALTHY VOLUNTEER SUBJECTS AND PATIENTS WITH PARKINSONS-DISEASE, ARCHIVES OF NEUROLOGY, Vol: 47, Pages: 1290-1298, ISSN: 0003-9942
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- Citations: 344
COLEBATCH JG, FINDLEY LJ, FRACKOWIAK RSJ, et al., 1990, PRELIMINARY-REPORT - ACTIVATION OF THE CEREBELLUM IN ESSENTIAL TREMOR, LANCET, Vol: 336, Pages: 1028-1030, ISSN: 0140-6736
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- Citations: 159
BROOKS DJ, IBANEZ V, SAWLE GV, et al., 1990, DIFFERING PATTERNS OF STRIATAL F-18 DOPA UPTAKE IN PARKINSONS-DISEASE, MULTIPLE SYSTEM ATROPHY, AND PROGRESSIVE SUPRANUCLEAR PALSY, ANNALS OF NEUROLOGY, Vol: 28, Pages: 547-555, ISSN: 0364-5134
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- Citations: 538
BROOKS DJ, SALMON EP, MATHIAS CJ, et al., 1990, THE RELATIONSHIP BETWEEN LOCOMOTOR DISABILITY, AUTONOMIC DYSFUNCTION, AND THE INTEGRITY OF THE STRIATAL DOPAMINERGIC SYSTEM IN PATIENTS WITH MULTIPLE SYSTEM ATROPHY, PURE AUTONOMIC FAILURE, AND PARKINSONS-DISEASE, STUDIED WITH PET, BRAIN, Vol: 113, Pages: 1539-1552, ISSN: 0006-8950
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- Citations: 241
Brooks DJ, Salmon EP, Mathias CJ, et al., 1990, The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson's disease, studied with PET., Brain, Vol: 113 ( Pt 5), Pages: 1539-1552, ISSN: 0006-8950
18F-dopa and S-11C-nomifensine (NMF) are positron emitting tracers whose caudate and putamen uptake reflects striatal dopamine storage capacity and the integrity of dopamine reuptake sites, respectively. Using these two tracers, the integrity of the presynaptic striatal dopaminergic system has been studied with positron emission tomography (PET) in 10 subjects with multiple system atrophy (MSA, Shy-Drager syndrome) who had an akinetic-rigid syndrome that was poorly responsive to L-dopa, autonomic failure, and cerebellar ataxia. PET findings for the 10 MSA patients were compared with those for 13 age-matched controls, 8 subjects with L-dopa responsive Parkinson's disease (PD), and 7 subjects with pure autonomic failure (PAF). Influx constants, Ki, reflecting specific 18F-dopa uptake into striatal tissue, were severely reduced in the putamen and caudate of the 10 MSA subjects (mean putamen Ki 0.005 min-1 MSA vs 0.013 min-1 controls; mean caudate Ki 0.007 min-1 MSA vs 0.013 min-1 controls). Reduction of putamen, but not caudate, 18F-dopa uptake correlated with severity and duration of locomotor disability. Eight patients with PD, and a similar degree and duration of locomotor disability to the patients with MSA, demonstrated equal impairment of mean putamen 18F-dopa uptake, but significant preservation of mean caudate function. The 7 PAF patients had normal mean levels of putamen and caudate 18F-dopa uptake, although 1 individual PAF patient had significantly impaired striatal function. The MSA and PD groups of subjects both showed significantly reduced levels of specific striatal S-11C-NMF binding, again caudate function being relatively preserved in PD. It is concluded that in both MSA and PD there is a parallel decline of striatal dopamine storage capacity and reuptake site integrity, probably reflecting a loss of nigrostriatal nerve terminals. Caudate function is relatively preserved in PD compared with MSA. The majority of PAF patients have an intact nigrostriatal
SALMON E, BROOKS DJ, LEENDERS KL, et al., 1990, A 2-COMPARTMENT DESCRIPTION AND KINETIC PROCEDURE FOR MEASURING REGIONAL CEREBRAL [C-11] NOMIFENSINE UPTAKE USING POSITRON EMISSION TOMOGRAPHY, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 10, Pages: 307-316, ISSN: 0271-678X
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- Citations: 70
COLEMAN RE, 1990, NATIONAL-CANCER-INSTITUTE WORKSHOP STATEMENT - ADVANCES IN CLINICAL IMAGING USING POSITRON EMISSION TOMOGRAPHY, SEPTEMBER 14-16, 1988, ARCHIVES OF INTERNAL MEDICINE, Vol: 150, Pages: 735-739, ISSN: 0003-9926
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- Citations: 1
Leenders KL, Perani D, Lammertsma AA, et al., 1990, Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age., Brain, Vol: 113 ( Pt 1), Pages: 27-47, ISSN: 0006-8950
Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), oxygen utilization (CMRO2) and blood volume (CBV) were measured in a group of 34 healthy volunteers (age range 22-82 yrs) using the 15O steady-state inhalation method and positron emission tomography. Between subjects CBF correlated positively with CMRO2, although the interindividual variability of the measured values was large. OER was not dependent on CMRO2, but highly negatively correlated with CBF. CBV correlated positively with CBF. When considering the values of all the regions of interest within a single subject, a strict coupling between CMRO2 and CBF, and between CBF and CBV was found, while OER was constant and independent of CBF and CMRO2. In 'pure' grey and white matter regions CMRO2, CBF and CBV decreased with age approximately 0.50% per year. In other regions the decline was less evident, most likely due to partial volume effects. OER did not change or showed a slight increase with age (maximum in the grey matter region 0.35%/yr). The results suggest diminished neuronal firing or decreased dendritic synaptic density with age.
LEENDERS KL, PERANI D, LAMMERTSMA AA, et al., 1990, CEREBRAL BLOOD-FLOW, BLOOD-VOLUME AND OXYGEN UTILIZATION - NORMAL VALUES AND EFFECT OF AGE, BRAIN, Vol: 113, Pages: 27-47, ISSN: 0006-8950
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- Citations: 873
BEANEY RP, BROOKS DJ, JONES T, 1990, THE LATE EFFECTS OF CEREBRAL IRRADIATION, BRITISH JOURNAL OF CANCER, Vol: 61, Pages: 165-166, ISSN: 0007-0920
SAWLE GV, BROOKS DJ, 1990, POSITRON EMISSION TOMOGRAPHY STUDIES OF NEUROTRANSMITTER SYSTEMS, JOURNAL OF NEUROLOGY, Vol: 237, Pages: 451-456, ISSN: 0340-5354
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- Citations: 5
BROOKS DJ, 1989, POSITRON EMISSION TOMOGRAPHIC STUDIES OF THE SUBCORTICAL DEGENERATIONS AND DYSTONIA, SEMINARS IN NEUROLOGY, Vol: 9, Pages: 351-359, ISSN: 0271-8235
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- Citations: 4
GODLEE FN, BROOKS DJ, IMPALLOMENI M, 1989, DYSKINESIA IN THE ELDERLY PRESENTING AS RESPIRATORY DISORDER, POSTGRADUATE MEDICAL JOURNAL, Vol: 65, Pages: 830-831, ISSN: 0032-5473
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- Citations: 7
BROOKS DJ, REDMOND S, MATHIAS CJ, et al., 1989, THE EFFECT OF ORTHOSTATIC HYPOTENSION ON CEREBRAL BLOOD-FLOW AND MIDDLE CEREBRAL-ARTERY VELOCITY IN AUTONOMIC FAILURE, WITH OBSERVATIONS ON THE ACTION OF EPHEDRINE, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 52, Pages: 962-966, ISSN: 0022-3050
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- Citations: 90
BROOKS DJ, FRACKOWIAK RSJ, 1989, PET AND MOVEMENT-DISORDERS, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Pages: 68-77, ISSN: 0022-3050
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- Citations: 21
Brooks DJ, Frackowiak RS, 1989, PET and movement disorders., J Neurol Neurosurg Psychiatry, Vol: Suppl, Pages: 68-77, ISSN: 0022-3050
In this paper the use of PET for determining the patterns of disruption of both regional cerebral metabolism, and the pre- and post-synaptic dopaminergic systems, associated with movement disorders is reviewed. That the various akinetic-rigid syndromes result in distinctive PET findings is shown, making functional imaging valuable in their differential diagnosis. PET may also be useful for detecting the presence of sub-clinical disease in Huntington's disease and other inherited movement disorders.
BROOKS DJ, LUTHERT P, GADIAN D, et al., 1989, DOES SIGNAL-ATTENUATION ON HIGH-FIELD T2-WEIGHTED MRI OF THE BRAIN REFLECT REGIONAL CEREBRAL IRON DEPOSITION - OBSERVATIONS ON THE RELATIONSHIP BETWEEN REGIONAL CEREBRAL WATER PROTON T2 VALUES AND IRON LEVELS, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 52, Pages: 108-111, ISSN: 0022-3050
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- Citations: 83
BROOKS DJ, REDMOND S, BANNISTER R, et al., 1988, THE EFFECT OF EPHEDRINE ON CEREBRAL BLOOD-FLOW AND MIDDLE CEREBRAL-ARTERY VELOCITY IN PATIENTS WITH ORTHOSTATIC HYPOTENSION, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 51, Pages: 1359-1359, ISSN: 0022-3050
FISH DR, BROOKS DJ, YOUNG IR, et al., 1988, USE OF MAGNETIC-RESONANCE IMAGING TO IDENTIFY CHANGES IN CEREBRAL BLOOD-FLOW IN EPILEPSIA PARTIALIS CONTINUA, MAGNETIC RESONANCE IN MEDICINE, Vol: 8, Pages: 238-240, ISSN: 0740-3194
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- Citations: 13
FISH DR, LEWIS TT, BROOKS DJ, et al., 1987, REGIONAL CEREBRAL BLOOD-FLOW OF PATIENTS WITH FOCAL EPILEPSY STUDIED USING XENON ENHANCED CT BRAIN-SCANNING, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 50, Pages: 1584-1588, ISSN: 0022-3050
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- Citations: 12
BEANEY RP, LEENDERS KL, BROOKS DJ, 1987, EFFECTS OF DEXAMETHASONE IN BRAIN-TUMOR PATIENTS, LANCET, Vol: 1, Pages: 571-572, ISSN: 0140-6736
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- Citations: 4
BROOKS DJ, CARR DH, LEGG NJ, 1987, THE ROLE OF DELAYED COMPUTED TOMOGRAPHIC SCANNING USING HIGH-DOSES OF CONTRAST MATERIAL IN DETECTING CEREBRAL DEMYELINATION IN PATIENTS WITH MULTIPLE-SCLEROSIS IN RELAPSE AND REMISSION, BRITISH JOURNAL OF RADIOLOGY, Vol: 60, Pages: 295-297, ISSN: 0007-1285
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- Citations: 1
BEANEY RP, GIBBS JSR, BROOKS DJ, et al., 1987, ABSENCE OF IRRADIATION INDUCED ISCHEMIC TEMPORAL-LOBE DAMAGE IN PATIENTS WITH PITUITARY-TUMORS, JOURNAL OF NEURO-ONCOLOGY, Vol: 5, Pages: 129-137, ISSN: 0167-594X
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- Citations: 7
LAMMERTSMA AA, BROOKS DJ, FRACKOWIAK RSJ, et al., 1987, MEASUREMENT OF GLUCOSE-UTILIZATION WITH [F-18] 2-FLUORO-2-DEOXY-D-GLUCOSE - A COMPARISON OF DIFFERENT ANALYTICAL METHODS, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 7, Pages: 161-172, ISSN: 0271-678X
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- Citations: 85
SPEIRS CJ, NAVEY FL, BROOKS DJ, et al., 1986, OPISTHOTONOS AND BENZODIAZEPINE WITHDRAWAL IN THE ELDERLY, LANCET, Vol: 2, Pages: 1101-1101, ISSN: 0140-6736
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- Citations: 7
BROOKS DJ, BEANEY RP, POWELL M, et al., 1986, STUDIES ON CEREBRAL OXYGEN-METABOLISM, BLOOD-FLOW, AND BLOOD-VOLUME, IN PATIENTS WITH HYDROCEPHALUS BEFORE AND AFTER SURGICAL DECOMPRESSION, USING POSITRON EMISSION TOMOGRAPHY, BRAIN, Vol: 109, Pages: 613-628, ISSN: 0006-8950
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- Citations: 50
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