Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Brooks:2020:10.1007/978-3-030-53176-8_30,
author = {Brooks, DJ},
booktitle = {PET and SPECT of Neurobiological Systems},
doi = {10.1007/978-3-030-53176-8_30},
pages = {1021--1040},
title = {PET imaging of translocator protein expression in neurological disorders},
url = {http://dx.doi.org/10.1007/978-3-030-53176-8_30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Microglia provide the intrinsic immune defence of the brain and are activated by any injurious process. As such they provide a non-specific marker of disease activity. Their function can be both detrimental and beneficial as they release cytokines which drive disease progression but also release restorative growth factors, help clear cellular debris and abnormal protein aggregations and can remodel connections as an adaptive response to brain damage. Activated microglia express translocator protein (TSPO), and this allows them to be imaged in vivo with positron emission tomography (PET) radioligands which are substrates. In this review the role of TSPO imaging with PET is discussed in neurodegenerative and inflammatory brain diseases and in focal brain injury due to trauma or stroke.
AU  - Brooks,DJ
DO  - 10.1007/978-3-030-53176-8_30
EP  - 1040
PY  - 2020///
SN  - 9783030531751
SP  - 1021
TI  - PET imaging of translocator protein expression in neurological disorders
T1  - PET and SPECT of Neurobiological Systems
UR  - http://dx.doi.org/10.1007/978-3-030-53176-8_30
ER  -
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