Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dani:2015:10.1016/j.parkreldis.2015.08.011,
author = {Dani, M and Edison, P and Brooks, DJ},
doi = {10.1016/j.parkreldis.2015.08.011},
journal = {Parkinsonism & Related Disorders},
pages = {S26--S28},
title = {Imaging biomarkers in tauopathies},
url = {http://dx.doi.org/10.1016/j.parkreldis.2015.08.011},
volume = {22},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid cognitive dysfunction and neuron loss. Selective PET ligands including [18F]THK5117, [18F]THK5351, [18F]AV1451 (T807) and [11C]PBB3 now provide in vivo imaging information about the timing and distribution of tau in the early phases of neurodegenerative diseases. They are potential imaging biomarkers for both supporting diagnosis and tracking disease progression. Here, we discuss the challenges posed in developing selective tau ligands as biomarkers, their state of development and the new clinical information that has been revealed.
AU  - Dani,M
AU  - Edison,P
AU  - Brooks,DJ
DO  - 10.1016/j.parkreldis.2015.08.011
EP  - 28
PY  - 2015///
SN  - 1353-8020
SP  - 26
TI  - Imaging biomarkers in tauopathies
T2  - Parkinsonism & Related Disorders
UR  - http://dx.doi.org/10.1016/j.parkreldis.2015.08.011
VL  - 22
ER  -
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