Imperial College London
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Dr David C Muller

Faculty of Medicine, School of Public Health

Senior Lecturer in Cancer Epidemiology and Biostatistics
 
 
 
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Contact

 

david.muller

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Severi:2014:10.1002/cam4.281,
author = {Severi, G and FitzGerald, LM and Muller, DC and Pedersen, J and Longano, A and Southey, MC and Hopper, JL and English, DR and Giles, GG and Mills, J},
doi = {10.1002/cam4.281},
journal = {Cancer Medicine},
pages = {1266--1274},
title = {A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease},
url = {http://dx.doi.org/10.1002/cam4.281},
volume = {3},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Only a minority of prostate cancers lead to death. Because no tissue biomarkers of aggressiveness other than Gleason score are available at diagnosis, many nonlethal cancers are treated aggressively. We evaluated whether a panel of biomarkers, associated with a range of disease outcomes in previous studies, could predict death from prostate cancer for men with localized disease. Using a case-only design, subjects were identified from three Australian epidemiological studies. Men who had died of their disease, "cases" (N = 83), were matched to "referents" (N = 232), those who had not died of prostate cancer, using incidence density sampling. Diagnostic tissue was retrieved to assess expression of AZGP1, MUC1, NKX3.1, p53, and PTEN by semiquantitative immunohistochemistry (IHC). Poisson regression was used to estimate mortality rate ratios (MRRs) adjusted for age, Gleason score, and stage and to estimate survival probabilities. Expression of MUC1 and p53 was associated with increased mortality (MRR 2.51, 95% CI 1.14-5.54, P = 0.02 and 3.08, 95% CI 1.41-6.95, P = 0.005, respectively), whereas AZGP1 expression was associated with decreased mortality (MRR 0.44, 95% CI 0.20-0.96, P = 0.04). Analyzing all markers under a combined model indicated that the three markers were independent predictors of prostate cancer death and survival. For men with localized disease at diagnosis, assessment of AZGP1, MUC1, and p53 expression in diagnostic tissue by IHC could potentially improve estimates of risk of dying from prostate cancer based only on Gleason score and clinical stage.
AU  - Severi,G
AU  - FitzGerald,LM
AU  - Muller,DC
AU  - Pedersen,J
AU  - Longano,A
AU  - Southey,MC
AU  - Hopper,JL
AU  - English,DR
AU  - Giles,GG
AU  - Mills,J
DO  - 10.1002/cam4.281
EP  - 1274
PY  - 2014///
SN  - 2045-7634
SP  - 1266
TI  - A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease
T2  - Cancer Medicine
UR  - http://dx.doi.org/10.1002/cam4.281
UR  - http://hdl.handle.net/10044/1/33944
VL  - 3
ER  -
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