Publications
507 results found
Blagden S, Olmin A, Josephs D, et al., 2014, First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer, CLINICAL CANCER RESEARCH, Vol: 20, Pages: 5908-5917, ISSN: 1078-0432
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- Citations: 30
Pinato DJ, Karamanakos G, Arizumi T, et al., 2014, Dynamic changes of the inflammation-based index predict mortality following chemoembolisation for hepatocellular carcinoma: a prospective study, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 40, Pages: 1270-1281, ISSN: 0269-2813
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- Citations: 27
Pinato DJ, 2014, Cancer-Related Inflammation: An Emerging Prognostic Domain in Metastatic Castration-Resistant Prostate Carcinoma, CANCER, Vol: 120, Pages: 3272-3274, ISSN: 0008-543X
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- Citations: 7
Pinato DJ, Pirisi M, Maslen L, et al., 2014, Tissue Biomarkers of Prognostic Significance in Hepatocellular Carcinoma, ADVANCES IN ANATOMIC PATHOLOGY, Vol: 21, Pages: 270-284, ISSN: 1072-4109
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- Citations: 14
Pinato DJ, Ishizuka M, Karamanakos G, et al., 2014, The London Liver Cancer Score (LLCS): A novel and validated prognostic algorithm in hepatocellular carcinoma., 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Pinato DJ, Shiner RJ, Seckl MJ, et al., 2014, Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer, BRITISH JOURNAL OF CANCER, Vol: 110, Pages: 1930-1935, ISSN: 0007-0920
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- Citations: 124
Pinato DJ, Karamanakos G, Goyal A, et al., 2014, DYNAMIC CHANGES OF THE INFLAMMATION BASED INDEX (IBI) AS A PREDICTOR OF MORTALITY FOLLOWING TRANS-ARTERIAL CHEMOEMBOLIZATION FOR HEPATOCELLULAR CARCINOMA, 49th Annual International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S400-S400, ISSN: 0168-8278
Grossi G, Smirne C, Burlone ME, et al., 2014, THE RED CELL DISTRIBUTION WIDTH (RDW) IS A NOVEL POWERFUL, INEXPENSIVE PREDICTOR OF SURVIVAL FOR PATIENTS WHO PRESENT WITH HEPATOCELLULAR CARCINOMA, 49th Annual International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S254-S255, ISSN: 0168-8278
Pinato DJ, Tan W, Gately A, 2014, An Unexpected Cause of Pulmonary Cannonball Lesion, JOURNAL OF THORACIC ONCOLOGY, Vol: 9, Pages: 259-259, ISSN: 1556-0864
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- Citations: 1
Libri V, Gibbs JSR, Pinato DJ, et al., 2014, Capsaicin 8% patch for treprostinil subcutaneous infusion site pain in pulmonary hypertension patients, BRITISH JOURNAL OF ANAESTHESIA, Vol: 112, Pages: 337-347, ISSN: 0007-0912
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- Citations: 2
Grossi G, Smirne C, Pinato DJ, et al., 2014, RED CELL DISTRIBUTION WIDTH (RDW) IS A NOVEL POWERFUL, INEXPENSIVE PREDICTOR OF SURVIVAL FOR PATIENTS WHO PRESENT WITH HEPATOCELLULAR CARCINOMA, DIGESTIVE AND LIVER DISEASE, Vol: 46, Pages: E36-E36, ISSN: 1590-8658
Stavraka C, Pinato DJ, Turnbull SJ, et al., 2014, Developing an Objective Marker to Optimize Patient Selection and Predict Survival Benefit in Early-Phase Cancer Trials, CANCER, Vol: 120, Pages: 262-270, ISSN: 0008-543X
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- Citations: 13
Mohamed Z, Pinato DJ, Mauri FA, et al., 2014, Inflammation as a validated prognostic determinant in carcinoma of unknown primary site, BRITISH JOURNAL OF CANCER, Vol: 110, Pages: 208-213, ISSN: 0007-0920
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- Citations: 19
Pinato DJ, Mauri FA, 2014, Metastatic Spread of Lung Cancer to Brain and Liven Role of CX3CR1, BRAIN METASTASES FROM PRIMARY TUMORS, VOL 1: EPIDEMIOLOGY, BIOLOGY, AND THERAPY, Editors: Hayat, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 123-129, ISBN: 978-0-12-800896-6
Pinato DJ, Tan TM, Toloue S, et al., 2013, An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes., British Journal of Cancer, Vol: 110, ISSN: 1532-1827
Pinato DJ, Bains J, Irkulla S, et al., 2013, Advanced age influences the dynamic changes in circulating C-reactive protein following injury, JOURNAL OF CLINICAL PATHOLOGY, Vol: 66, Pages: 695-699, ISSN: 0021-9746
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- Citations: 13
Pinato DJ, Sharma R, 2013, Imatinib induced pyoderma gangrenosum, JOURNAL OF POSTGRADUATE MEDICINE, Vol: 59, Pages: 244-245, ISSN: 0022-3859
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- Citations: 10
Bains J, Mansukhani S, Coates S, et al., 2013, Concurrent computerized tomography can optimize the detection of cancer in patients presenting with unexplained anaemia., British Society of Gastroenterology Annual Meeting
Pinato DJ, Tan TM, Toloue-Kalami-Toussi S, et al., 2013, AN EXPRESSION SIGNATURE OF THE ANGIOGENIC RESPONSE IN GASTROINTESTINAL NEUROENDOCRINE TUMOURS: CORRELATION WITH TUMOUR PHENOTYPE AND SURVIVAL OUTCOMES, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A29-A29, ISSN: 0017-5749
Adjogatse DA, Karamanakos G, Pinato DJ, et al., 2013, The inflammation based index (IBI) predicts survival advantage after transarterial chemoembolization in hepatocellular carcinoma., ASCO Annual Meeting 2013
Pinato DJ, Graham J, Gabra H, et al., 2013, Evolving concepts in the management of drug resistant ovarian cancer: Dose dense chemotherapy and the reversal of clinical platinum resistance, CANCER TREATMENT REVIEWS, Vol: 39, Pages: 153-160, ISSN: 0305-7372
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- Citations: 49
Pinato DJ, Nya P, Sharma R, et al., 2013, CD24: a potential new marker in differentiating malignant mesothelioma from pulmonary adenocarcinoma, JOURNAL OF CLINICAL PATHOLOGY, Vol: 66, Pages: 256-259, ISSN: 0021-9746
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- Citations: 3
Pinato DJ, Mauri FA, Lloyd T, et al., 2013, The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma, BRITISH JOURNAL OF CANCER, Vol: 108, Pages: 621-628, ISSN: 0007-0920
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- Citations: 28
Pinato DJ, Ramachandran R, Toussi STK, et al., 2013, Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations, BRITISH JOURNAL OF CANCER, Vol: 108, Pages: 429-437, ISSN: 0007-0920
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- Citations: 34
Libri V, Brown AP, Gambarota G, et al., 2012, A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers, PLoS ONE, Vol: 7, ISSN: 1932-6203
Background:SRT2104 has been developed as a selective small molecule activator of SIRT1, a NAD+-dependent deacetylaseinvolved in the regulation of energy homeostasis and the modulation of various metabolic pathways, including glucosemetabolism, oxidative stress and lipid metabolism. SIRT1 has been suggested as putative therapeutic target in multiple age-related diseases including type 2 diabetes and dyslipidemias. We report the first clinical trial of SRT2104 in elderlyvolunteers.Methods:Oral doses of 0.5 or 2.0 g SRT2104 or matching placebo were administered once daily for 28 days.Pharmacokinetic samples were collected through 24 hours post-dose on days 1 and 28. Multiple pharmacodynamicendpoints were explored with oral glucose tolerance tests (OGTT), serum lipid profiles, magnetic resonance imaging (MRI)for assessment of whole body visceral and subcutaneous fat, maximal aerobic capacity test and muscle 31P magneticresonance spectroscopy (MRS) for estimation of mitochondrial oxidative capacity.Results:SRT2104 was generally safe and well tolerated. Pharmacokinetic exposure increased less than dose-proportionally.Mean Tmax was 2–4 hours with elimination half-life of 15–20 hours. Serum cholesterol, LDL levels and triglyceridesdecreased with treatment. No significant changes in OGTT responses were observed. 31P MRS showed trends for morerapid calculated adenosine diphosphate (ADP) and phosphocreatine (PCr) recoveries after exercise, consistent withincreased mitochondrial oxidative phosphorylation.Conclusions:SRT2104 can be safely administered in elderly individuals and has biological effects in humans that areconsistent with SIRT1 activation. The results of this study support further development of SRT2104 and may be useful indose selection for future clinical trials in patients.
Hussein M, Pinato DJ, Ramachandran R, et al., 2012, MGMT expression in Paragangliomas and Phaeochromocytomas, UKI NETS 10th National Conference
Pinato DJ, Stavraka C, Tanner M, et al., 2012, Clinical, Ethical and Financial Implications of Incidental Imaging Findings: Experience from a Phase I Trial inHealthy Elderly Volunteers, Plos One, Vol: 7
Stavraka1, Mark Tanner2, Audrey Esson1, Eric W. Jacobson3, Martin R. Wilkins1,Vincenzo Libri1*
Mohamed Z, Pinato DJ, Sharma R, 2012, NOVEL INFLAMMATION-BASED PROGNOSTIC DETERMINANTS IN PATIENTS WITH CARCINOMA OF UNKNOWN PRIMARY, 37th Congress of the European-Society-for-Medical-Oncology (ESMO), Publisher: OXFORD UNIV PRESS, Pages: 381-381, ISSN: 0923-7534
Pinato DJ, Sharma R, 2012, An inflammation-based prognostic index predicts survival advantage after transarterial chemoembolization in hepatocellular carcinoma, TRANSLATIONAL RESEARCH, Vol: 160, Pages: 146-152, ISSN: 1931-5244
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- Citations: 56
Mauri FA, Pinato DJ, Trivedi P, et al., 2012, Isogeneic comparison of primary and metastatic lung cancer identifies CX3CR1 as a molecular determinant of site-specific metastatic diffusion, ONCOLOGY REPORTS, Vol: 28, Pages: 647-653, ISSN: 1021-335X
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- Citations: 10
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