BibTex format
@inproceedings{Pinato:2011,
author = {Pinato, DJ and Wasan, HS and Maslen, L and North, BV and Sharma, R},
title = {A novel inflammatory-based prognostic score in hepatocellular carcinoma.},
year = {2011}
}
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TY - CPAPER
AB - Background: In the management of hepatocellular cancer (HCC) several prognostic systems exist however these are inconsistent. Inflammation is associated with both pathogenesis and prognosis of HCC. We therefore explored the prognostic impact of 3 inflammation based prognostic scores; the Glasgow Prognostic Score (GPS), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), and compared their accuracy with the conventional BCLC and CLIP scores in order to identify a more adequate prognostic model for HCC. Methods: Patients had a diagnosis of HCC either on radiological or histological criteria as per American Association for the Study of the Liver guidelines. Patients with a history of inflammatory disease or infection were excluded. Clinical variables including demographic data, CBP, albumin, CRP, AFP, liver function tests, tumour stage including number and diameter of hepatic lesions, Child-Turcotte Pugh class, CLIP and BCLC scores were collected. GPS, NLR and PLR scoring systems were generated. Kaplan Meier statistics and log rank test were used to assess OS with each prognostic score. C-index was used to rank different staging systems. Results were then validated in an independent data set. Results: 112 consecutive patients presenting between 1993 and 2010 were included (mean age 62, range 20-83), Child Turcotte Pugh Class A 65%, intermediate/advanced BCLC Staging Algorithm 81%. Median overall survival 6.3 months. On univariate analysis GPS (p<0.001), NLR (p=0.006), PLR (p=0.01), CLIP (p<0.001) and BCLC score (p=0.002) were significant predictors of overall survival. Multivariate analysis: GPS (p=0.01) and CLIP scores (p=0.006) independent predictors of survival. CLIP score and GPS ranked as most informative staging systems, with a respective c-index score of 0.685 (95% CI 0.549-0.820) and 0.640 (95% CI 0.532-0.747). The predictive accuracy of the combined GPS and CLIP score was superior to that of the CLIP score alone, combined c-index score
AU - Pinato,DJ
AU - Wasan,HS
AU - Maslen,L
AU - North,BV
AU - Sharma,R
PY - 2011///
TI - A novel inflammatory-based prognostic score in hepatocellular carcinoma.
ER -