Imperial College London

ProfessorEricAboagye

Faculty of MedicineDepartment of Surgery & Cancer

Professor
 
 
 
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Contact

 

+44 (0)20 3313 3759eric.aboagye

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

GN1Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

332 results found

Willaime JMY, Turkheimer FE, Kenny LM, Aboagye EOet al., 2012, Image descriptors of intra-tumor proliferative heterogeneity predict chemotherapy response in breast tumors, http://jnumedmtg.snmjournals.org/cgi/content/meeting_abstract/53/1_MeetingAbstracts/387, SNM Annual Meeting, Publisher: J Nucl Med

Conference paper

Aboagye EO, Iddon L, Leyton J, Cuthbertson A, Indrevoll B, Glaser M, Luthra Set al., 2012, WO2012/118909: Radiolabelled octreotate analogues as PET tracers

Patent

Glaser M, Goggi J, Smith G, Morrison M, Luthra SK, Robins E, Aboagye EOet al., 2011, Improved radiosynthesis of the apoptosis marker F-18-ICMT11 including biological evaluation, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 21, Pages: 6945-6949, ISSN: 0960-894X

Journal article

Tomasi G, Kenny L, Mauri F, Turkheimer F, Aboagye EOet al., 2011, Quantification of receptor-ligand binding with [F-18]fluciclatide in metastatic breast cancer patients, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 38, Pages: 2186-2197, ISSN: 1619-7070

Journal article

Leyton J, Iddon L, Perumal M, Indrevoll B, Glaser M, Robins E, George AJT, Cuthbertson A, Luthra SK, Aboagye EOet al., 2011, Targeting Somatostatin Receptors: Preclinical Evaluation of Novel F-18-Fluoroethyltriazole-Tyr(3)-Octreotate Analogs for PET, JOURNAL OF NUCLEAR MEDICINE, Vol: 52, Pages: 1441-1448, ISSN: 0161-5505

Journal article

Sharma R, Aboagye E, 2011, Development of radiotracers for oncology - the interface with pharmacology, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 163, Pages: 1565-1585, ISSN: 0007-1188

Journal article

Quang-De N, Perumal M, Waldman TA, Aboagye EOet al., 2011, Glucose Metabolism Measured by [F-18]Fluorodeoxyglucose Positron Emission Tomography Is Independent of PTEN/AKT Status in Human Colon Carcinoma Cells, TRANSLATIONAL ONCOLOGY, Vol: 4, Pages: 241-248, ISSN: 1936-5233

Journal article

Golinska M, Troy H, Chung Y-L, McSheehy PM, Mayr M, Yin X, Ly L, Williams KJ, Airley RE, Harris AL, Latigo J, Perumal M, Aboagye EO, Perrett D, Stubbs M, Griffiths JRet al., 2011, Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas, BMC CANCER, Vol: 11, ISSN: 1471-2407

Journal article

Iddon L, Leyton J, Indrevoll B, Glaser M, Robins EG, George AJT, Cuthbertson A, Luthra SK, Aboagye EOet al., 2011, Synthesis and in vitro evaluation of [F-18]fluoroethyl triazole labelled [Tyr(3)]octreotate analogues using click chemistry, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 21, Pages: 3122-3127, ISSN: 0960-894X

Journal article

Kenny LM, Al-Nahhas A, Aboagye EO, 2011, Novel PET biomarkers for breast cancer imaging, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 32, Pages: 333-335, ISSN: 0143-3636

Journal article

Nguyen Q-D, Smith G, Carroll LS, Graham MA, Aboagye EOet al., 2011, Noninvasive early assessment of tumor response to the SMAC mimetic TL32711 with a caspase-3/7-specific PET imaging radiotracer, CANCER RESEARCH, Vol: 71, ISSN: 0008-5472

Journal article

Pisaneschi F, Sejberg JJP, Blain C, Ng WH, Aboagye EO, Spivey ACet al., 2011, 2-Substituted-2,3-dihydro-1H-quinolin-4-ones via Acid-Catalyzed Tandem Rupe Rearrangement-Donnelly-Farrell Ring Closure of 2-(3 '-Hydroxypropynyl)anilines, SYNLETT, Pages: 241-244, ISSN: 0936-5214

Journal article

Smith G, Zhao Y, Leyton J, Shan B, Nguyen Q-D, Perumal M, Turton D, Arstad E, Luthra SK, Robins EG, Aboagye EOet al., 2011, Radiosynthesis and pre-clinical evaluation of [F-18]fluoro-[1,2-H-2(4)]choline, NUCLEAR MEDICINE AND BIOLOGY, Vol: 38, Pages: 39-51, ISSN: 0969-8051

Journal article

Smith G, Carroll L, Sala R, Leyton J, Nguyen Q-D, Behan K, Twyman F, Robins E, Aboagye Eet al., 2011, Synthesis and evaluation of nucleoside radiotracers for imaging tumour proliferation, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 54, Pages: S214-S214, ISSN: 0362-4803

Journal article

Winkle RF, Smith G, de Mello AJ, Aboagye EOet al., 2011, Automated HPLC free microfluidic synthesis of [F-18]fluoromethyl tosylate, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 54, Pages: S544-S544, ISSN: 0362-4803

Journal article

Contractor KB, Challapalli A, Barwick T, Winkler M, Hellawell G, Hazell S, Tomasi G, Al-Nahhas A, Mapelli P, Kenny L, Tadrous P, Coombes RC, Aboagye EO, Mangar Set al., 2011, Use of [11C]choline PET-CT as a non invasive method for detecting pelvic lymph node status from prostate cancer and relationship with choline kinase expression, ISSN: 1078-0432

PURPOSE: To evaluate the accuracy and biological basis for [11C] choline-PET-CT in the nodal staging of high risk localised prostate cancer patients.EXPERIMENTAL DESIGN: Twenty eight patients underwent dynamic [11C] choline-PET-CT of the pelvis and lower abdomen prior to extended laparoscopic pelvic lymph node dissection (eLPL). The sensitivity and specificity of [11C]choline PET, [11C]choline PET-CT and MRI for nodal detection were calculated. Average and maximal standardized Uptake Values (SUVave, SUVmax) were compared with choline kinase alpha (CHKalpha) and Ki67 immunohistochemistry scores.RESULTS: 406 lymph nodes, in 26 patients, were assessable. 27 (6.7%) involved pelvic nodes at eLPL were detected in 9 patients. 17 out of the 27 involved nodes were sub-centimetre. The sensitivity and specificity on a per nodal basis were 18.5 % and 98.7%, 40.7% and 98.4 %, and 51.9% and 98.4% for MRI, [11C]choline PET and [11C]choline PET-CT, respectively. Sensitivity was higher for [11C]choline PET-CT compared with MRI (p=0.007). A higher nodal detection rate, including sub-centimetre nodes, was seen with [11C]choline PET-CT than MRI. Malignant lesions showed CHKalpha expression in both cytoplasm and nucleus. SUVave and SUVmax strongly correlated with CHKalpha staining intensity (r=0.68, p<0.0001 and r=0.63, p=0.0004, respectively). In contrast, Ki67 expression was generally low in all tumors. CONCLUSIONS: This study establishes the relationship between [11C]choline PET- CT uptake with choline kinase expression in prostate cancer and allows it to be used as a non-invasive means of staging pelvic lymph nodes, being highly specific and more sensitive than MRI including the detection of sub-centimetre disease.

Journal article

Contractor KB, Kenny LM, Stebbing J, Challapalli A, Al-Nahhas A, Palmieri C, Shousha S, Lewis JS, Hogben K, De Nguyen Q, Coombes RC, Aboagye EOet al., 2011, Biological basis of [11C]choline-positron emission tomography in patients with breast cancer: comparison with [18F]fluorothymidine positron emission tomography, ISSN: 1473-5628

OBJECTIVE: The biological significance of [C]choline (CHO) uptake in human tumours is unclear and probably linked to choline kinase-alpha (CHKalpha) expression and cell proliferation. We directly compared CHO with [F]fluorothymidine (FLT), an imaging biomarker of proliferation, by positron emission tomography (PET) in patients with breast cancer to investigate whether cell proliferation is an important determinant of CHO uptake. Furthermore, we evaluated CHKalpha and the Ki67-labelling index (LIKi67) in tumour biopsies. METHODS: Sequential CHO-PET and FLT-PET within the same imaging session were performed in 21 patients with oestrogen receptor (ER)-positive breast cancer (28 lesions). Average and maximum CHO standardized uptake values (SUV) at 60 min: SUV60,av, and SUV60,max, and the rate constant of net irreversible uptake, Ki, were compared with FLT uptake at 60 min: SUV60,av and SUV60,max. Biopsies were stained for CHKalpha and LIKi67 in eight cases. RESULTS: Tumours were equally visible on CHO-PET and FLT-PET imaging. Tumour CHO-PET strongly correlated with FLT imaging variables (Pearson's r=0.83; P<0.0001 for CHO-SUV60,max vs. FLT-SUV60,max). A statistically significant association was found between CHO-PET variables and categorical scores of cytoplasmic CHKalpha intensity and between FLT-PET and LIKi67 (P<0.05, one-way analysis of variance). CONCLUSION: Choline metabolism and proliferation as assessed by PET were correlated in ER-positive breast cancer, indicating that high CHO uptake is a measure of cellular proliferation in this setting. CHO uptake was also found to be related to cytoplasmic CHKalpha expression.

Journal article

Contractor KB, Kenny L, Stebbing J, Rosso L, Ahmad R, Jacob J, Challapalli A, Turkheimer F, Al-Nahhas A, Sharma R, Coombes RC, Aboagye EOet al., 2011, [18F]-3'deoxy-3'-Fluorothymidine Positron Emission Tomography and Breast Cancer Response to Docetaxel, ISSN: 1078-0432

PURPOSE: To establish biomarkers indicating clinical response to taxanes, we determined whether early changes in [18F]-3'deoxy-3'-fluorothymidine positron emission tomography (FLT-PET) can predict benefit from docetaxel therapy in breast cancer.EXPERIMENTAL DESIGN: This was a prospective unblinded study in 20 patients with AJCC stage II-IV breast cancer unresponsive to first-line chemotherapy or progressing on previous therapy. Individuals underwent a baseline dynamic FLT-PET scan followed by a scan two weeks after initiating the first or second cycle of docetaxel. PET variables were compared to anatomical response mid-therapy (after 3 cycles). RESULTS: Average and maximum tumor standardized uptake values at 60 min (SUV60,av and SUV60,max) normalized to body surface area ranged between 1.7 and 17.0, and 5.6 and 26.9 x 10-5 m2/mL, respectively. Docetaxel treatment resulted in a significant decrease in FLT uptake (p=0.0003 for SUV60,av and p=0.0002 for SUV60,max). Reduction in tumor SUV60,av was associated with target lesion size changes mid-therapy (Pearson R for SUV60,av=0.64; p=0.004) and predicted mid-therapy target lesion response (0.85 sensitivity and 0.80 specificity). Decreases in SUV60,av in responders were due at least in part, to reduced net intracellular trapping of FLT (rate constant Ki). Docetaxel significantly reduced Ki by 51.1% (+/-28.4%, p=0.0009).CONCLUSIONS: Changes in tumor proliferation assessed by FLT-PET early after initiating docetaxel chemotherapy can predict lesion response mid-therapy with good sensitivity warranting prospective trials to assess the ability to stop therapy in the event of non-FLT-PET response.

Journal article

Aboagye EO, 2010, The future of imaging: developing the tools for monitoring response to therapy in oncology: the 2009 Sir James MacKenzie Davidson Memorial lecture, BRITISH JOURNAL OF RADIOLOGY, Vol: 83, Pages: 814-822, ISSN: 0007-1285

Journal article

Pisaneschi F, Nguyen Q-D, Shamsaei E, Glaser M, Robins E, Kaliszczak M, Smith G, Spivey AC, Aboagye EOet al., 2010, Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: Synthesis and biological evaluation, BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 18, Pages: 6634-6645, ISSN: 0968-0896

Journal article

Hatt M, Rest CC-L, Aboagye EO, Kenny LM, Rosso L, Turkheimer FE, Albarghach NM, Metges J-P, Pradier O, Visvikis Det al., 2010, Reproducibility of F-18-FDG and 3 '-Deoxy-3 '-F-18-Fluorothymidine PET Tumor Volume Measurements, JOURNAL OF NUCLEAR MEDICINE, Vol: 51, Pages: 1368-1376, ISSN: 0161-5505

Journal article

Kenny LM, Contractor KB, Hinz R, Stebbing J, Palmieri C, Jiang J, Shousha S, Al-Nahhas A, Coombes RC, Aboagye EOet al., 2010, Reproducibility of [C-11]Choline-Positron Emission Tomography and Effect of Trastuzumab, CLINICAL CANCER RESEARCH, Vol: 16, Pages: 4236-4245, ISSN: 1078-0432

Journal article

Aboagye EO, 2010, Phosphatidylcholine Metabolic Transformation and Progression Signature as a Pharmacodynamic Biomarker, ONCOTARGET, Vol: 1, Pages: 163-166

Journal article

Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DAH, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA, Navaratnam V, Ryder Set al., 2010, Guidelines for the welfare and use of animals in cancer research, BRITISH JOURNAL OF CANCER, Vol: 102, Pages: 1555-1577, ISSN: 0007-0920

Journal article

Akiyoshi T, Heathcote DA, Azzi J, Zhang M, Rodig SJ, El-Haddad N, Yang S, Moore RF, Sayegh MH, Ashton-Rickardt PG, Abdi Ret al., 2010, The Role of SPI6 in the Survival of Allograft Derived Dendritic Cells and Tolerance., AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 10, Pages: 561-561, ISSN: 1600-6135

Journal article

Gray KR, Contractor KB, Kenny LM, Al-Nahhas A, Shousha S, Stebbing J, Wasan HS, Coombes RC, Aboagye EO, Turkheimer FE, Rosso Let al., 2010, Kinetic filtering of [F-18]Fluorothymidine in positron emission tomography studies, PHYSICS IN MEDICINE AND BIOLOGY, Vol: 55, Pages: 695-709, ISSN: 0031-9155

Journal article

Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kannegnti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, Snyder JP, Liotta DC, Freemont PS, Aboagye EO, Coombes RC, Barrett AG, Ali Set al., 2010, A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration, J Med Chem, Vol: 53, Pages: 8508-8522

Cyclin-dependent protein kinases (CDKs) are central to the appropriate regulation of cell proliferation, apoptosis, and gene expression. Abnormalities in CDK activity and regulation are common features of cancer, making CDK family members attractive targets for the development of anticancer drugs. Here, we report the identification of a pyrazolo[1,5-a]pyrimidine derived compound, 4k (BS-194), as a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 (IC= 3, 30, 30, 250, and 90 nmol/L, respectively). Cell-based studies showed inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G/M phases. Consistent with these findings, 4k demonstrated potent antiproliferative activity in 60 cancer cell lines tested (mean GI= 280 nmol/L). Pharmacokinetic studies showed that 4k is orally bioavailable, with an elimination half-life of 178 min following oral dosing in mice. When administered at a concentration of 25 mg/kg orally, 4k inhibited human tumor xenografts and suppressed CDK substrate phosphorylation. These findings identify 4k as a novel, potent CDK selective inhibitor with potential for oral delivery in cancer patients.

Journal article

Nguyen Q-D, Aboagye EO, 2010, Imaging the life and death of tumors in living subjects: Preclinical PET imaging of proliferation and apoptosis, INTEGRATIVE BIOLOGY, Vol: 2, Pages: 483-495, ISSN: 1757-9694

Journal article

Aboagye EO, Spivey A, Pisaneschi F, 2010, WO2010GB02325: Quinoline derivatives used as PET imaging agents

Patent

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