Imperial College London
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Eric Lim

Faculty of Medicine, National Heart & Lung Institute

Professor of Thoracic Surgery
 
 
 
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Contact

 

+44 (0)20 7351 8591eric.lim

 
 
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Location

 

Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dietel:2015:10.1136/thoraxjnl-2014-206677,
author = {Dietel, M and Bubendorf, L and Dingemans, A-MC and Dooms, C and Elmberger, G and Calero, Garcia R and Kerr, KM and Lim, E and Lopez-Rios, F and Thunnissen, E and Van, Schil PE and von, Laffert M},
doi = {10.1136/thoraxjnl-2014-206677},
journal = {Thorax},
pages = {177--184},
title = {Diagnostic procedures for non-small-cell lung cancer (NSCLC): recommendations of the European Expert Group},
url = {http://dx.doi.org/10.1136/thoraxjnl-2014-206677},
volume = {71},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background There is currently no Europe-wide consensus on the appropriate preanalytical measures and workflow to optimise procedures for tissue-based molecular testing of non-small-cell lung cancer (NSCLC). To address this, a group of lung cancer experts (see list of authors) convened to discuss and propose standard operating procedures (SOPs) for NSCLC.Methods Based on earlier meetings and scientific expertise on lung cancer, a multidisciplinary group meeting was aligned. The aim was to include all relevant aspects concerning NSCLC diagnosis. After careful consideration, the following topics were selected and each was reviewed by the experts: surgical resection and sampling; biopsy procedures for analysis; preanalytical and other variables affecting quality of tissue; tissue conservation; testing procedures for epidermal growth factor receptor, anaplastic lymphoma kinase and ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) in lung tissue and cytological specimens; as well as standardised reporting and quality control (QC). Finally, an optimal workflow was described.Results Suggested optimal procedures and workflows are discussed in detail. The broad consensus was that the complex workflow presented can only be executed effectively by an interdisciplinary approach using a well-trained team.Conclusions To optimise diagnosis and treatment of patients with NSCLC, it is essential to establish SOPs that are adaptable to the local situation. In addition, a continuous QC system and a local multidisciplinary tumour-type-oriented board are essential.
AU  - Dietel,M
AU  - Bubendorf,L
AU  - Dingemans,A-MC
AU  - Dooms,C
AU  - Elmberger,G
AU  - Calero,Garcia R
AU  - Kerr,KM
AU  - Lim,E
AU  - Lopez-Rios,F
AU  - Thunnissen,E
AU  - Van,Schil PE
AU  - von,Laffert M
DO  - 10.1136/thoraxjnl-2014-206677
EP  - 184
PY  - 2015///
SN  - 0040-6376
SP  - 177
TI  - Diagnostic procedures for non-small-cell lung cancer (NSCLC): recommendations of the European Expert Group
T2  - Thorax
UR  - http://dx.doi.org/10.1136/thoraxjnl-2014-206677
UR  - http://hdl.handle.net/10044/1/39461
VL  - 71
ER  -
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