Imperial College London
Alternate

ProfessorFanChung

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 7954f.chung Website

 
 
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Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
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Location

 

227BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Feng:2023:10.21037/jtd-22-1731,
author = {Feng, Y and Xie, M and Liu, Q and Weng, J and Wei, L and Chung, KF and Adcock, IM and Chang, Q and Li, M and Huang, Y and Zhang, H and Li, F},
doi = {10.21037/jtd-22-1731},
journal = {Journal of Thoracic Disease},
pages = {2544--2558},
title = {Changes in targeted metabolomics in lung tissue of chronic obstructive pulmonary disease.},
url = {http://dx.doi.org/10.21037/jtd-22-1731},
volume = {15},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common chronic lung disease and its incidence is steadily increasing. COPD patients and mouse models of COPD share some similarities in lung pathology and physiology. We performed this study to explore the potential metabolic pathways involved in the pathogenesis of COPD and to discover the COPD-associated biomarkers. Furthermore, we aimed to examine how much the mouse model of COPD was similar and different to human COPD in terms of the altered metabolites and pathways. METHODS: Twenty human lung tissue samples (ten COPD and ten controls) and twelve mice lung tissue samples (six COPD and six controls) were analyzed by targeted HM350 metabolomics, and multivariate and pathway analysis were performed by Kyoto Encyclopedia of Genes and Genomes (KEGG) database. RESULTS: The counts of many metabolites such as amino acids, carbohydrates and carnitines were changed in both COPD patients and mice compared to controls, respectively. While lipid metabolism was changed only in COPD mice. After KEGG analysis, we found these altered metabolites involved in COPD through aging, apoptosis, oxidative stress and inflammation pathways. CONCLUSIONS: The expressions of metabolites changed in both COPD patients and cigarette smoke exposed (CS-exposed) mice. And there were also some differences between COPD patients and mouse models due to the differences between species. Our study suggested the dysregulation in amino acid metabolism, energy production pathway and perhaps lipid metabolism may be significantly related to the pathogenesis of COPD.
AU  - Feng,Y
AU  - Xie,M
AU  - Liu,Q
AU  - Weng,J
AU  - Wei,L
AU  - Chung,KF
AU  - Adcock,IM
AU  - Chang,Q
AU  - Li,M
AU  - Huang,Y
AU  - Zhang,H
AU  - Li,F
DO  - 10.21037/jtd-22-1731
EP  - 2558
PY  - 2023///
SN  - 2072-1439
SP  - 2544
TI  - Changes in targeted metabolomics in lung tissue of chronic obstructive pulmonary disease.
T2  - Journal of Thoracic Disease
UR  - http://dx.doi.org/10.21037/jtd-22-1731
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37324094
UR  - https://jtd.amegroups.com/article/view/75360/html
UR  - http://hdl.handle.net/10044/1/105013
VL  - 15
ER  -
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