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@article{Bertels:2023:10.1136/bmjresp-2023-001760,
author = {Bertels, X and Edris, A and Garcia-Aymerich, J and Faner, R and Meteran, H and Sigsgaard, T and Alter, P and Vogelmeier, C and Olvera, N and Kermani, NZ and Agusti, A and Donaldson, GC and Wedzicha, JA and Brusselle, GG and Backman, H and Ronmark, E and Lindberg, A and Vonk, JM and Chung, KF and Adcock, IM and van, den Berge M and Lahousse, L},
doi = {10.1136/bmjresp-2023-001760},
journal = {BMJ Open Respiratory Research},
title = {Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration},
url = {http://dx.doi.org/10.1136/bmjresp-2023-001760},
volume = {10},
year = {2023}
}

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TY  - JOUR
AB  - Background The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts.Methods This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1/FVC <0.7 in population-based and clinic-based cohorts, respectively. Clinical characteristics and comorbidities of AO were compared with asthma without airflow obstruction (asthma-only) and chronic obstructive pulmonary disease (COPD) without asthma history (COPD-only). ORs for comorbidities adjusted for age, sex, smoking status and body mass index (BMI) were meta-analysed using a random effects model.Results The prevalence of AO was 2.1% (95% CI 2.0% to 2.2%) in population-based, 21.1% (95% CI 18.6% to 23.8%) in asthma-based and 16.9% (95% CI 15.8% to 17.9%) in COPD-based cohorts. AO patients had more often clinically relevant dyspnoea (modified Medical Research Council score ≥2) than asthma-only (+14.4 and +14.7 percentage points) and COPD-only (+24.0 and +5.0 percentage points) in population-based and clinic-based cohorts, respectively. AO patients had more often elevated blood eosinophil counts (>300 cells/µL), although only significant in population-based cohorts. Compared with asthma-only, AO patients were more often men, current smokers, with a lower BMI, had less often obesity and had more often chronic bronchitis. Compared with COPD-only, AO patients were younger, less often current smokers and had less pack-years. In the general population, AO patients had a higher risk of coronary artery disease than asthma-only and COPD-only (OR=2.09 (95% CI 1.26 to 3.47) and OR=1.89 (95% CI 1.10 to 3.24), respectively) and of depression (OR=1.41 (95% CI 1.19 to 1.67)), osteoporosis (OR=2.30 (95% CI 1.43 to 3.72)) and gastro-oesophageal reflux disease (OR=1
AU  - Bertels,X
AU  - Edris,A
AU  - Garcia-Aymerich,J
AU  - Faner,R
AU  - Meteran,H
AU  - Sigsgaard,T
AU  - Alter,P
AU  - Vogelmeier,C
AU  - Olvera,N
AU  - Kermani,NZ
AU  - Agusti,A
AU  - Donaldson,GC
AU  - Wedzicha,JA
AU  - Brusselle,GG
AU  - Backman,H
AU  - Ronmark,E
AU  - Lindberg,A
AU  - Vonk,JM
AU  - Chung,KF
AU  - Adcock,IM
AU  - van,den Berge M
AU  - Lahousse,L
DO  - 10.1136/bmjresp-2023-001760
PY  - 2023///
SN  - 2052-4439
TI  - Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration
T2  - BMJ Open Respiratory Research
UR  - http://dx.doi.org/10.1136/bmjresp-2023-001760
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001054198300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://bmjopenrespres.bmj.com/content/10/1/e001760
UR  - http://hdl.handle.net/10044/1/107904
VL  - 10
ER  -

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