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@article{Yasinska:2023:10.1183/23120541.00269-2023,
author = {Yasinska, V and Gomez, C and Kolmert, J and Ericsson, M and Pohanka, A and James, A and Andersson, LI and Sparreman-Mikus, M and Sousa, AR and Riley, JH and Bates, S and Bakke, PS and Kermani, NZ and Caruso, M and Chanez, P and Fowler, SJ and Geiser, T and Howarth, PH and Horvath, I and Krug, N and Montuschi, P and Sanak, M and Behndig, A and Shaw, DE and Knowles, RG and Dahlen, B and Maitland-van, der Zee A-H and Sterk, PJ and Djukanovic, R and Adcock, IM and Chung, KF and Wheelock, CE and Dahlen, S-E and Jonsson, EW},
doi = {10.1183/23120541.00269-2023},
journal = {ERJ Open Research},
title = {Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids},
url = {http://dx.doi.org/10.1183/23120541.00269-2023},
volume = {9},
year = {2023}
}

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TY  - JOUR
AB  - Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure.Methods Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study.Measurements and main results The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12–18months.Conclusion The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma.
AU  - Yasinska,V
AU  - Gomez,C
AU  - Kolmert,J
AU  - Ericsson,M
AU  - Pohanka,A
AU  - James,A
AU  - Andersson,LI
AU  - Sparreman-Mikus,M
AU  - Sousa,AR
AU  - Riley,JH
AU  - Bates,S
AU  - Bakke,PS
AU  - Kermani,NZ
AU  - Caruso,M
AU  - Chanez,P
AU  - Fowler,SJ
AU  - Geiser,T
AU  - Howarth,PH
AU  - Horvath,I
AU  - Krug,N
AU  - Montuschi,P
AU  - Sanak,M
AU  - Behndig,A
AU  - Shaw,DE
AU  - Knowles,RG
AU  - Dahlen,B
AU  - Maitland-van,der Zee A-H
AU  - Sterk,PJ
AU  - Djukanovic,R
AU  - Adcock,IM
AU  - Chung,KF
AU  - Wheelock,CE
AU  - Dahlen,S-E
AU  - Jonsson,EW
DO  - 10.1183/23120541.00269-2023
PY  - 2023///
SN  - 2312-0541
TI  - Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
T2  - ERJ Open Research
UR  - http://dx.doi.org/10.1183/23120541.00269-2023
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001075451800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://openres.ersjournals.com/content/9/5/00269-2023
UR  - http://hdl.handle.net/10044/1/107902
VL  - 9
ER  -

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