Imperial College London
Alternate

ProfessorFanChung

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 7954f.chung Website

 
 
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Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
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Location

 

227BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jin:2023:10.1183/23120541.00461-2023,
author = {Jin, FD and Wang, J and Deng, SJ and Song, W-J and Zhang, X and Wang, CY and Gao, SY and Chung, KF and Yang, Y and Vertigan, AE and Luo, FM and Birring, SS and Li, WM and Liu, D and Wang, G},
doi = {10.1183/23120541.00461-2023},
journal = {ERJ Open Res},
title = {Interaction effect of chronic cough and ageing on increased risk of exacerbation in patients with asthma: a prospective cohort study in a real-world setting.},
url = {http://dx.doi.org/10.1183/23120541.00461-2023},
volume = {9},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Older adults with asthma have the greatest burden and worst outcomes, and there is increasing evidence that chronic cough (CC) is associated with asthma severity and poor prognosis. However, the clinical characteristics of older adult patients with both asthma and CC remain largely unknown. METHODS: Participants with stable asthma underwent two cough assessments within 3months to define the presence of CC. Patients were divided into four groups based on CC and age (cut-off ≥60years). Multidimensional assessment was performed at baseline, followed by a 12-month follow-up to investigate asthma exacerbations. Logistic regression models were used to explore the interaction effect of CC and age on asthma control and exacerbations. RESULTS: In total, 310 adult patients were prospectively recruited and divided into four groups: older CC group (n=46), older non-CC group (n=20), younger CC group (n=112) and younger non-CC group (n=132). Compared with the younger non-CC group, the older CC group had worse asthma control and quality of life and increased airflow obstruction. The older CC group showed an increase in moderate-to-severe exacerbations during the 12-month follow-up. There was a significant interaction effect of CC and ageing on the increased moderate-to-severe exacerbations (adjusted risk ratio 2.36, 95% CI 1.47-3.30). CONCLUSION: Older asthma patients with CC have worse clinical outcomes, including worse asthma control and quality of life, increased airway obstruction and more frequent moderate-to-severe exacerbations, which can be partly explained by the interaction between CC and ageing.
AU  - Jin,FD
AU  - Wang,J
AU  - Deng,SJ
AU  - Song,W-J
AU  - Zhang,X
AU  - Wang,CY
AU  - Gao,SY
AU  - Chung,KF
AU  - Yang,Y
AU  - Vertigan,AE
AU  - Luo,FM
AU  - Birring,SS
AU  - Li,WM
AU  - Liu,D
AU  - Wang,G
DO  - 10.1183/23120541.00461-2023
PY  - 2023///
SN  - 2312-0541
TI  - Interaction effect of chronic cough and ageing on increased risk of exacerbation in patients with asthma: a prospective cohort study in a real-world setting.
T2  - ERJ Open Res
UR  - http://dx.doi.org/10.1183/23120541.00461-2023
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38152080
VL  - 9
ER  -
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