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@article{Cornice:2024:10.3390/genes15020197,
author = {Cornice, J and Verzella, D and Arboretto, P and Vecchiotti, D and Capece, D and Zazzeroni, F and Franzoso, G},
doi = {10.3390/genes15020197},
journal = {Genes},
title = {NF-κB: governing macrophages in cancer},
url = {http://dx.doi.org/10.3390/genes15020197},
volume = {15},
year = {2024}
}

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TY  - JOUR
AB  - Tumor-associated macrophages (TAMs) are the major component of the tumor microenvironment (TME), where they sustain tumor progression and or-tumor immunity. Due to their plasticity, macrophages can exhibit anti- or pro-tumor functions through the expression of different gene sets leading to distinct macrophage phenotypes: M1-like or pro-inflammatory and M2-like or anti-inflammatory. NF-κB transcription factors are central regulators of TAMs in cancers, where they often drive macrophage polarization toward an M2-like phenotype. Therefore, the NF-κB pathway is an attractive therapeutic target for cancer immunotherapy in a wide range of human tumors. Hence, targeting NF-κB pathway in the myeloid compartment is a potential clinical strategy to overcome microenvironment-induced immunosuppression and increase anti-tumor immunity. In this review, we discuss the role of NF-κB as a key driver of macrophage functions in tumors as well as the principal strategies to overcome tumor immunosuppression by targeting the NF-κB pathway.
AU  - Cornice,J
AU  - Verzella,D
AU  - Arboretto,P
AU  - Vecchiotti,D
AU  - Capece,D
AU  - Zazzeroni,F
AU  - Franzoso,G
DO  - 10.3390/genes15020197
PY  - 2024///
SN  - 2073-4425
TI  - NF-κB: governing macrophages in cancer
T2  - Genes
UR  - http://dx.doi.org/10.3390/genes15020197
UR  - http://hdl.handle.net/10044/1/109790
VL  - 15
ER  -

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Professor Guido Franzoso

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