BibTex format
@article{Seemungal:1996,
author = {Seemungal, T and Paul, EA and Donaldson, GC and Wedzicha, JA},
journal = {Thorax},
title = {Factors predisposing to exacerbations in patients with COPD},
volume = {51},
year = {1996}
}
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TY - JOUR
AB - Exacerbations of COPD occur commonly in patients with moderate or severe disease but factors affecting frequency are not well known. Between October 1995 and May 1996, 88 COPD patients (60M, 28F, mean(SD) age 68.1(10.3) yrs, FEV1 1.02(0.43) 1, FVC 2.40(0.81) 1, FEV1/FVC 44%(14), PO2 8.84 (1.12) kPa,) from East London were given diary cards on which they recorded various parameters including daily peak flow and respiratory symptoms. Diagnosis of exacerbation was based on Anthonisen et al (Ann Intern Med. 1987:106; 196-204), incorporating primary symptoms (dyspnoea and sputum) and various secondary symptoms. This was determined by the same physician when patients were reviewed monthly from diary card data (unreported exacerbation) or at acute visit (reported exacerbation). In 66(75%) of these patients there were 166 exacerbations of which 96(58%) were reported. The mean fall in FEV1 to first reported exacerbation was 0.035(0.18) 1. The frequency of exacerbations was compared with possible predisposing factors (p-value), sex (0.67), chronic sinusitis or rhinitis (0.17), cardiac failure (0.72), number of lower respiratory tract infections in the previous year (0.04), currently smoking (0.34), smoking pack years (0.41), daily cough (0.57), daily dyspnoea (0.50), daily wheeze (0.04), daily sputum (0.16), inhaled steroid dose (0.49), oral steroid dose (0.49), long term oxygen therapy (0.58), hypoxia PaO2 < 8 kPa (0.37), PaC02 > 6.5 kPa (0.23), FEV1 < 0.8 1 (0.94). Thus patients with a number of previous exacerbations and daily reported wheeze are at greater risk of exacerbation. This supports the classification of COPD patients into "exacerbators" and "non-exacerbators".
AU - Seemungal,T
AU - Paul,EA
AU - Donaldson,GC
AU - Wedzicha,JA
PY - 1996///
SN - 0040-6376
TI - Factors predisposing to exacerbations in patients with COPD
T2 - Thorax
VL - 51
ER -