Imperial College London
Alternate

Emeritus ProfessorGavinDonaldson

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Respiratory Studies
 
 
 
//

Contact

 

+44 (0)20 7594 7859gavin.donaldson

 
 
//

Location

 

B141Guy Scadding BuildingRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Seemungal:1997,
author = {Seemungal, T and Donaldson, GC and Paul, EA and Bhowmik, A and Bestall, JC and Wedzicha, JA},
journal = {Thorax},
title = {Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease},
volume = {52},
year = {1997}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Exacerbations occur commonly in patients with moderate or severe COPD though effects on quality of life are unknown. 70 COPD patients (52M, 18F, mean(sd) age 67.5(8.3) yrs, FEV1 1.07(0.44) 1, FVC 2.50(0.80) 1, FEV1 reversibility 6.6 (9.6)%, PaO2 8.8 (1.1) kPa measured daily PEFR and daily respiratory symptoms for one year. Health - related quality of life was measured with the St. George's Respiratory Questionnaire (SGRQ). In 61(87%) patients there were 190 exacerbations, mean 2.7(1.5) exacerbations per patient per year. Over the 2 days prior to onset of exacerbation peak flow fell by a median(IQR) of - 6.6 (-16.7,0) 1/min (p < 0.001) per patient for mean(SD) 11.1(6.1) days. SGRQ scores were Total 57.1(16.6), Symptoms 66.3(19.9), Activities 74.9(17.6), Impacts 44.0(18.8) and these were related to the frequency of exacerbations (p): total score (p<0.001), symptoms (p<0.001), activities (p = 0.002), impacts (p = 0.001) but not to fall in PEFR nor to duration of fall in PEFR at exacerbation (p > 0.45). Factors predisposing to frequent exacerbations were past exacerbations(PE), daily cough(C), daily wheeze (W), and combination of daily cough and sputum, (CS) and these were also correlated with SGRQ scores (r values): SGRQ Score PE C W CS Total 0.33 0.123 0.39 0.13 Symptoms 0.54 0.20 0.39 0.25 Activities 0.27 0.05 0.16 0.07 Impacts 0.24 0.13 0.42 0.10 p<0.01 p<0.05 COPD exacerbations and their predisposing factors affect quality of life. Reduction of exacerbation frequency may be expected to improve health status in COPD.
AU  - Seemungal,T
AU  - Donaldson,GC
AU  - Paul,EA
AU  - Bhowmik,A
AU  - Bestall,JC
AU  - Wedzicha,JA
PY  - 1997///
SN  - 0040-6376
TI  - Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease
T2  - Thorax
VL  - 52
ER  -
Download