BibTex format
@article{Donaldson:1997,
author = {Donaldson, GC and Seemungal, T and Evans, C and Wedzicha, JA},
journal = {Thorax},
title = {Effect of cold exposure on lung function in COPD patients with exacerbation},
volume = {52},
year = {1997}
}
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TY - JOUR
AB - Patients with COPD deteriorate in the winter, although the effect of cold exposure on lung function during stability and exacerbation are unknown. Nine COPD patients (8 M, 1F; mean age ± SEM, 67.6 ± 2.7 years; PaO2 9.48 ± 0.18 kPa, FEV1 0.71 ± 0.06 1 and reversibility 10.0 ± 4.5%) were exposed, seated, wearing outdoor clothing, to cold still air at 4.1 ± 0.6 °C for 30 min in a climatic chamber on two occasions, once when clinically stable and once when experiencing an exacerbation, as diagnosed using the criteria of Anthonisen (Ann Intern Med 106:196-204, 1987). On average the two occasions were 170 ± 40 days apart; barometric pressure was not significantly different. FEV1 and FVC were measured twice before entering the climatic chamber (at 22.3 ± 0.5 °C) and then after 30 min using a bellows type spirometer (Vitalograph) at ATPS, which previous studies show give valid results under similar conditions (Perks et al. Thorax 38: 592-594 1983; Cramer et al. Thorax 39: 771-774, 1984). When stable, FEV1 fell from 0.71 ± 0.06 1 to 0.61 ± 0.08 1 (P=0.031; paired t-test) and FVC by 2.10 ± 0.21 1 to 1.86 ± 0.27 1 (P=0.087). With exacerbation, 5.1 ± 1.2 days after onset, FEV1 fell from 0.63 ± 0.04 1 to 0.59 ± 0.04 1 (P=0.046) and FVC by 2.03 ± 0.23 1 to 1.87 ± 0.18 1 (P=0.122). Falls in FEV1 (as % of FEV1 at room temperature, to adjust for lower FEV1 at exacerbation) were 16.4 ±. 6.4% (without) and 6.3 ± 2.7 % (with exacerbation) (P=0.048). These results suggest that cold air has an immediate detrimental effect on FEV1 , which is more pronounced when the patient is free from exacerbation; possibly because the ability of the airways to constrict is reduced.
AU - Donaldson,GC
AU - Seemungal,T
AU - Evans,C
AU - Wedzicha,JA
PY - 1997///
SN - 0040-6376
TI - Effect of cold exposure on lung function in COPD patients with exacerbation
T2 - Thorax
VL - 52
ER -