Imperial College London
Alternate

Emeritus ProfessorGavinDonaldson

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Respiratory Studies
 
 
 
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Contact

 

+44 (0)20 7594 7859gavin.donaldson

 
 
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Location

 

B141Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wedzicha:2000,
author = {Wedzicha, JA and Seemungal, TA and MacCallum, PK and Paul, EA and Donaldson, GC and Bhowmik, A and Jeffries, DJ and Meade, TW},
journal = {Thromb Haemost},
pages = {210--215},
title = {Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels},
volume = {84},
year = {2000}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory tract infections may acutely increase risk from coronary heart disease (CHD), though the mechanisms have not been defined. Patients with chronic obstructive pulmonary disease (COPD) are prone to repeated exacerbations that are often associated with respiratory infections. These patients also have increased cardiovascular morbidity and mortality. We hypothesized that transient acute increases in plasma fibrinogen, an independent risk factor for CHD, could occur at COPD exacerbation (mediated through a rise in IL6) and thereby provide a mechanism linking respiratory infection to risk of coronary heart disease.
AU  - Wedzicha,JA
AU  - Seemungal,TA
AU  - MacCallum,PK
AU  - Paul,EA
AU  - Donaldson,GC
AU  - Bhowmik,A
AU  - Jeffries,DJ
AU  - Meade,TW
EP  - 215
PY  - 2000///
SN  - 0340-6245
SP  - 210
TI  - Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels
T2  - Thromb Haemost
VL  - 84
ER  -
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