Imperial College London
Emeritus Professor Herb Arst

Emeritus ProfessorHerbArst

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor of Microbial Genetics
 
 
 
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Contact

 

+44 (0)20 7594 2073h.arst

 
 
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Location

 

5.40Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Peñalva:2002:10.1128/MMBR.66.3.426-446.2002,
author = {Peñalva, MA and Arst, HN},
doi = {10.1128/MMBR.66.3.426-446.2002},
journal = {Microbiol Mol Biol Rev},
pages = {426--446},
title = {Regulation of gene expression by ambient pH in filamentous fungi and yeasts.},
url = {http://dx.doi.org/10.1128/MMBR.66.3.426-446.2002},
volume = {66},
year = {2002}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Life, as we know it, is water based. Exposure to hydroxonium and hydroxide ions is constant and ubiquitous, and the evolutionary pressure to respond appropriately to these ions is likely to be intense. Fungi respond to their environments by tailoring their output of activities destined for the cell surface or beyond to the ambient pH. We are beginning to glimpse how they sense ambient pH and transmit this information to the transcription factor, whose roles ensure that a suitable collection of gene products will be made. Although relatively little is known about pH signal transduction itself, its consequences for the cognate transcription factor are much clearer. Intriguingly, homologues of components of this system mediating the regulation of fungal gene expression by ambient pH are to be found in the animal kingdom. The potential applied importance of this regulatory system lies in its key role in fungal pathogenicity of animals and plants and in its control of fungal production of toxins, antibiotics, and secreted enzymes.
AU  - Peñalva,MA
AU  - Arst,HN
DO  - 10.1128/MMBR.66.3.426-446.2002
EP  - 446
PY  - 2002///
SN  - 1092-2172
SP  - 426
TI  - Regulation of gene expression by ambient pH in filamentous fungi and yeasts.
T2  - Microbiol Mol Biol Rev
UR  - http://dx.doi.org/10.1128/MMBR.66.3.426-446.2002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/12208998
VL  - 66
ER  -
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