Imperial College London
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Dr Harriet Kemp

Faculty of Medicine, Department of Surgery & Cancer

Clinical Lecturer
 
 
 
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Contact

 

h.kemp

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kemp:2020:10.1515/sjpain-2019-0152,
author = {Kemp, HI and Eliahoo, J and Vase, L and Nguyen, S and Ben, Abdallah A and Rice, ASC and Finnerup, NB and Haroutounian, S},
doi = {10.1515/sjpain-2019-0152},
journal = {Scandinavian Journal of Pain},
pages = {439--449},
title = {Meta-analysis comparing placebo responses in clinical trials of painful HIV-associated sensory neuropathy and diabetic polyneuropathy},
url = {http://dx.doi.org/10.1515/sjpain-2019-0152},
volume = {20},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and aims The placebo response has been identified as one factor responsible for the lack of therapeutic trials with positive outcomes in neuropathic pain. Reviews have suggested that certain neuropathic pain conditions, including HIV-associated sensory neuropathy (HIV-SN), exhibit a greater placebo response than other neuropathic aetiologies. If true, such a finding could substantially affect clinical trial design and therapeutic developments for these conditions. This study aimed to identify any difference in placebo response between trials of systemic pharmacological intervention in HIV-SN and a comparable neuropathic condition, diabetic polyneuropathy (DPN) and to identify factors influencing the placebo response. Methods A systematic review search to identify randomised, double-blind studies of systemic pharmacological interventions for painful HIV-SN and DPN published between January 1966 and June 2019 was performed. A meta-analysis of the magnitude of placebo response and the proportion of placebo responders was conducted and compared between the two disease conditions. A meta-regression was used to assess for any study and participant characteristics that were associated with the placebo response. Only studies meeting a methodological quality threshold were included. Results Seventy-five trials were identified. There was no statistically significant difference in the proportion of placebo responders (HIV-SN = 0.35; versus DPN = 0.27, p = 0.129). The difference observed in the magnitude of the placebo response [pain reduction of 1.68 (1.47-1.88) DPN; 2.38 (1.87-2.98) in HIV-SN] was based on only 2 trials of HIV-SN and 35 of DPN. Potential factors influencing the placebo response such as psychological measures, were reported inconsistently. Conclusions We found no statistically significant difference in the placebo response rate between painful HIV-SN and DPN. Too few studies were available that reported the
AU  - Kemp,HI
AU  - Eliahoo,J
AU  - Vase,L
AU  - Nguyen,S
AU  - Ben,Abdallah A
AU  - Rice,ASC
AU  - Finnerup,NB
AU  - Haroutounian,S
DO  - 10.1515/sjpain-2019-0152
EP  - 449
PY  - 2020///
SN  - 1877-8860
SP  - 439
TI  - Meta-analysis comparing placebo responses in clinical trials of painful HIV-associated sensory neuropathy and diabetic polyneuropathy
T2  - Scandinavian Journal of Pain
UR  - http://dx.doi.org/10.1515/sjpain-2019-0152
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32106088
UR  - https://www.degruyter.com/view/j/sjpain.ahead-of-print/sjpain-2019-0152/sjpain-2019-0152.xml
UR  - http://hdl.handle.net/10044/1/77493
VL  - 20
ER  -
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