Imperial College London
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DrIngridMuller

Faculty of Medicine, Department of Infectious Disease

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i.muller

 
 
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Location

 

120Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Noben-Trauth:1996:10.1126/science.271.5251.987,
author = {Noben-Trauth, N and Kropf, P and Müller, I},
doi = {10.1126/science.271.5251.987},
journal = {Science},
pages = {987--990},
title = {Susceptibility to Leishmania major infection in interleukin-4-deficient mice.},
url = {http://dx.doi.org/10.1126/science.271.5251.987},
volume = {271},
year = {1996}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Interleukin-4 (IL-4), a pleiotropic cytokine, is a major regulator of the immune system and is considered crucial for the development of T helper cell type 2 (TH2) responses. The susceptibility of BALB/c mice to infection with Leishmania major has been associated with a polarized TH2 response and an inability to down-modulate IL-4 production. The role of IL-4 in vivo was examined directly by disrupting the IL-4 gene in BALB/c embryonic stem cells. Despite the absence of IL-4, the genetically pure BALB/c mutant mice remained susceptible to L. major infection, showed no signs of lesion healing or parasite clearance, and did not switch to a TH1 phenotype.
AU  - Noben-Trauth,N
AU  - Kropf,P
AU  - Müller,I
DO  - 10.1126/science.271.5251.987
EP  - 990
PY  - 1996///
SN  - 0036-8075
SP  - 987
TI  - Susceptibility to Leishmania major infection in interleukin-4-deficient mice.
T2  - Science
UR  - http://dx.doi.org/10.1126/science.271.5251.987
UR  - https://www.ncbi.nlm.nih.gov/pubmed/8584936
VL  - 271
ER  -
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