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@article{Croucher:2021:10.1038/s41396-020-00867-w,
author = {Croucher, N and Harrow, G and Lees, J and Hanage, W and Lipsitch, M and Corander, J and Colijn, C},
doi = {10.1038/s41396-020-00867-w},
journal = {The ISME Journal: multidisciplinary journal of microbial ecology},
pages = {1523--1538},
title = {Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures},
url = {http://dx.doi.org/10.1038/s41396-020-00867-w},
volume = {15},
year = {2021}
}

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TY  - JOUR
AB  - Streptococcus pneumoniae can be divided into many strains, each a distinct set of isolates sharing similar core and accessorygenomes, which co-circulate within the same hosts. Previous analyses suggested the short-term vaccine-associated dynamicsof S. pneumoniae strains may be mediated through multi-locus negative frequency-dependent selection (NFDS), whichmaintains accessory loci at equilibrium frequencies. Long-term simulations demonstrated NFDS stabilised clonally-evolvingmulti-strain populations through preventing the loss of variation through drift, based on polymorphism frequencies,pairwise genetic distances and phylogenies. However, allowing symmetrical recombination between isolates evolving undermulti-locus NFDS generated unstructured populations of diverse genotypes. Replication of the observed data improvedwhen multi-locus NFDS was combined with recombination that was instead asymmetrical, favouring deletion of accessoryloci over insertion. This combination separated populations into strains through outbreeding depression, resulting fromrecombinants with reduced accessory genomes having lower fitness than their parental genotypes. Although simplisticmodelling of recombination likely limited these simulations’ ability to maintain some properties of genomic data asaccurately as those lacking recombination, the combination of asymmetrical recombination and multi-locus NFDS couldrestore multi-strain population structures from randomised initial populations. As many bacteria inhibit insertions into theirchromosomes, this combination may commonly underlie the co-existence of strains within a niche.
AU  - Croucher,N
AU  - Harrow,G
AU  - Lees,J
AU  - Hanage,W
AU  - Lipsitch,M
AU  - Corander,J
AU  - Colijn,C
DO  - 10.1038/s41396-020-00867-w
EP  - 1538
PY  - 2021///
SN  - 1751-7362
SP  - 1523
TI  - Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures
T2  - The ISME Journal: multidisciplinary journal of microbial ecology
UR  - http://dx.doi.org/10.1038/s41396-020-00867-w
UR  - https://www.nature.com/articles/s41396-020-00867-w
UR  - http://hdl.handle.net/10044/1/86008
VL  - 15
ER  -

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