Publications
517 results found
Delles C, Brown CE, McCarthy NS, et al., 2013, Urinary Proteomic Biomarkers to Predict Cardiovascular Events, American-Heart-Association High Blood Pressure Research Scientific Sessions, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0194-911X
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- Citations: 1
Kyriacou A, Wa MELK, Pabari PA, et al., 2013, A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 167, Pages: 954-964, ISSN: 0167-5273
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- Citations: 7
Ghosh AK, Hardy R, Francis DP, et al., 2013, Age at first detection of overweight and adult lfe course BMI are associated with future increased left ventricular mass index, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 150-150, ISSN: 0195-668X
Ghosh AK, Hughes AD, Francis DP, et al., 2013, Age at first detection of overweight and adult life course BMI are associated with future diastolic dysfunction, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 150-150, ISSN: 0195-668X
Khamis R, Batty T, Wong I, et al., 2013, Dissecting the protective IgG anti-malondialdehyde-LDL (MDA-LDL) antibody response in a substudy of the Anglo Scandinavian Cardiac Outcomes Trial (ASCOT), Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 141-141, ISSN: 0195-668X
Broyd CJ, Sen S, Mikhail GW, et al., 2013, Myocardial ischemia in aortic stenosis: Insights from arterial pulse-wave dynamics after percutaneous aortic valve replacement, TRENDS IN CARDIOVASCULAR MEDICINE, Vol: 23, Pages: 185-191, ISSN: 1050-1738
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- Citations: 17
Foin N, Sen S, Petraco R, et al., 2013, Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The "Stenotic Stent", JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 6, Pages: 640-648, ISSN: 1937-5387
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- Citations: 3
Tarkin J, Nijjer S, Sen S, et al., 2013, The haemodynamic response to intravenous adenosine and its impact on fractional flow reserve: results of the AFFECTS (Adenosine For the Functional assEssment of Coronary sTenosis Severity) study, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 514-514, ISSN: 0195-668X
Park CM, March K, Ghosh AK, et al., 2013, Left-Ventricular Structure in the Southall And Brent REvisited (SABRE) Study Explaining Ethnic Differences, HYPERTENSION, Vol: 61, Pages: 1014-+, ISSN: 0194-911X
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- Citations: 26
Sen S, Nijjer SS, Petraco R, et al., 2013, FRACTIONAL FLOW RESERVE AND THE INSTANT WAVE-FREE RATIO HAVE EQUIVALENT AGREEMENT WITH FLOW BASED INDICES ACROSS THE ENTIRE SPECTRUM OF STENOSIS SEVERITY RESULTS OF THE CLARIFY STUDY RESULTS OF CLARIFY, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, Pages: A35-A35, ISSN: 1355-6037
Sen S, Nijjer SS, Petraco R, et al., 2013, THE TRANS-STENOTIC PRESSURE GRADIENT DURING THE DIASTOLIC WAVE-FREE PERIOD IS PROPORTIONAL TO FLOW: THE PHYSIOLOGICAL BASIS OF THE INSTANT-WAVE-FREE RATIO, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037
Nijjer SSS, Sen S, Petraco R, et al., 2013, INSTANTANEOUS WAVE-FREE RATIO (IFR) CAN DETECT IMPROVEMENT IN CORONARY STENOSIS SEVERITY AFTER PERCUTANEOUS INTERVENTION, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, Pages: A37-A37, ISSN: 1355-6037
Tillin T, Hughes AD, Mayet J, et al., 2013, The Relationship Between Metabolic Risk Factors and Incident Cardiovascular Disease in Europeans, South Asians, and African Caribbeans SABRE (Southall and Brent Revisited)-A Prospective Population-Based Study, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 61, Pages: 1777-1786, ISSN: 0735-1097
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- Citations: 187
Unsworth B, Casula RP, Yadav H, et al., 2013, Contrasting effect of different cardiothoracic operations on echocardiographic right ventricular long axis velocities, and implications for interpretation of post-operative values, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 165, Pages: 151-160, ISSN: 0167-5273
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- Citations: 41
Sen S, Nijjer S, Petraco R, et al., 2013, The Effect of Adenosine on Coronary Microvascular Resistance Is More Consistent During the Diastolic Wave-free Period: Should We Continue to Use the Complete Cardiac Cycle for Stenosis Assessment?, 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 100B-101B, ISSN: 0002-9149
Nijjer SS, Sen S, Petraco R, et al., 2013, Instantaneous Wave-free Ratio Can Assess Improvement in Coronary Haemodynamics After Percutaneous Intervention., 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 100B-100B, ISSN: 0002-9149
Petraco R, Park JJ, Sen S, et al., 2013, Hybrid Ifr-FFR Decision-Making Strategy: Implications for Enhancing Universal Adoption of Physiology-Guided Coronary Revascularization., 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 54B-54B, ISSN: 0002-9149
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- Citations: 4
Sen S, Asrress K, Nijjer S, et al., 2013, Fractional Flow Reserve and The Instant Wave-free Ratio Have Equivalent Agreement with Flow Based Indices Across the Entire Spectrum of Stenosis Severity: Results of CLARIFY (The Classification Accuracy of Pressure-only Ratios Against Indices Using Flow Study)., 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 53B-53B, ISSN: 0002-9149
Sen S, Petraco R, Nijjer S, et al., 2013, The Instant Wave-free Ratio, a Vasodilator Free Index; Provides Lower Microvascular Resistance Than That During Adenosine Mediated Fractional Flow Reserve in a Significant Proportion of Patients., 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 101B-101B, ISSN: 0002-9149
Sen S, Petraco R, Nijjer S, et al., 2013, The Trans-stenotic Pressure Gradient During the Diastolic Wave-free Period Is Proportional to Flow: the Physiological Basis of the Instant-wave-free Ratio., 18th Angioplasty Summit Transcatheter Cardiovascular Therapeutics Asia Pacific (TCTAP), Publisher: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, Pages: 100B-100B, ISSN: 0002-9149
Hughes AD, Park C, Davies J, et al., 2013, Limitations of augmentation index in the assessment of wave reflection in normotensive healthy individuals, PLOS One, Vol: 8, ISSN: 1932-6203
ObjectivesAugmentation index (AIx) is widely used as a measure of wave reflection. We compared the relationship between AIx and age, height and sex with ‘gold standard’ measures of wave reflection derived from measurements of pressure and flow to establish how well AIx measures wave reflection.Materials and MethodsMeasurements of carotid pressure and flow velocity were made in the carotid artery of 65 healthy normotensive individuals (age 21–78 yr; 43 male) and pulse wave analysis, wave intensity analysis and wave separation was performed; waveforms were classified into type A, B or C. AIx, the time of the first shoulder (Ts), wave reflection index (WRI) and the ratio of backward to forward pressure (Pb/Pf) were calculated.ResultsAIx did not correlate with log WRI or Pb/Pf. When AIx was restricted to positive values AIx and log WRI were positively correlated (r = 0.33; p = 0.04). In contrast log WRI and Pb/Pf were closely correlated (r = 0.66; p<0.001). There was no correlation between the Ts and the timing of Pb or the reflected wave identified by wave intensity analysis. Wave intensity analysis showed that the morphology of type C waveforms (negative AIx) was principally due to a forward travelling (re-reflected) decompression wave in mid-systole. AIx correlated positively with age, inversely with height and was higher in women. In contrast log WRI and Pb/Pf showed negative associations with age, were unrelated to height and did not differ significantly by gender.ConclusionsAIx has serious limitations as a measure of wave reflection. Negative AIx values derived from Type C waves should not be used as estimates of wave reflection magnitude.
Ghosh AK, Hughes A, Chaturvedi N, et al., 2013, ADULT LIFE COURSE BODY MASS INDEX AND AGE AT FIRST DETECTION OF OVERWEIGHT ARE ASSOCIATED WITH FUTURE INCREASES IN LEFT VENTRICULAR MASS INDEX, 62nd Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: E1344-E1344, ISSN: 0735-1097
Turner HK, Norrington K, Barakat MF, et al., 2013, EVOLUTION OF ERYTHROCYTE INDICES TOWARD AN IRON DEFICIENT PICTURE PREDICTS EARLY MORTALITY IN ACUTE DECOMPENSATED HEART FAILURE, 62nd Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: E625-E625, ISSN: 0735-1097
Barakat MF, Chehab O, Hayat S, et al., 2013, ATTENUATIONS IN TISSUE DOPPLER-DERIVED LEFT VENTRICULAR SYSTOLIC VELOCITY PREDICT AN AMPLIFIED RISK OF LETHAL ARRHYTHMIAS IN ICD RECIPIENTS INDEPENDENTLY OF EJECTION FRACTION, 62nd Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: E818-E818, ISSN: 0735-1097
Kyriacou A, Whinnett ZI, Davies JE, et al., 2013, First-in-man evidence of the mechanistic effects of biventricular pacing on coronary physiology, Spring Meeting for Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 62-62, ISSN: 0140-6736
Davies JE, Manisty CH, Petraco R, et al., 2013, First-in-man safety evaluation of renal denervation for chronic systolic heart failure: Primary outcome from REACH-Pilot study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 162, Pages: 189-192, ISSN: 0167-5273
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- Citations: 206
Sen S, Davies J, Nijjer S, et al., 2013, FRACTIONAL FLOW RESERVE AND THE INSTANT WAVE–FREE RATIO HAVE EQUIVALENT AGREEMENT WITH FLOW–BASED INDICES ACROSS THE ENTIRE SPECTRUM OF STENOSIS SEVERITY RESULTS OF THE CLARIFY STUDY RESULTS OF CLARIFY (THE CLASSIFICATION ACCURACY OF PRESSURE–ONLY RATIOS AGAINST INDICES USING FLOW STUDY), ISSN: 0735-1097
Petraco R, Park JJ, Sen S, et al., 2013, Hybrid iFR-FFR decision-making strategy: implications for enhancing universal adoption of physiology-guided coronary revascularisation, EuroIntervention: journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Vol: 8, Pages: 1157-1165, ISSN: 1969-6213
AIMS: Adoption of fractional flow reserve (FFR) remains low (6-8%), partly because of the time, cost and potential inconvenience associated with vasodilator administration. The instantaneous wave-Free Ratio (iFR) is a pressure-only index of stenosis severity calculated without vasodilator drugs. Before outcome trials test iFR as a sole guide to revascularisation, we evaluate the merits of a hybrid iFR-FFR decision-making strategy for universal physiological assessment. METHODS AND RESULTS: Coronary pressure traces from 577 stenoses were analysed. iFR was calculated as the ratio between Pd and Pa in the resting diastolic wave-free window. A hybrid iFR-FFR strategy was evaluated, by allowing iFR to defer some stenoses (where negative predictive value is high) and treat others (where positive predictive value is high), with adenosine being given only to patients with iFR in between those values. For the most recent fixed FFR cut-off (0.8), an iFR of <0.86 could be used to confirm treatment (PPV of 92%), whilst an iFR value of >0.93 could be used to defer revascularisation (NPV of 91%). Limiting vasodilator drugs to cases with iFR values between 0.86 to 0.93 would obviate the need for vasodilator drugs in 57% of patients, whilst maintaining 95% agreement with an FFR-only strategy. If the 0.75-0.8 FFR grey zone is accounted for, vasodilator drug requirement would decrease by 76%. CONCLUSION: A hybrid iFR-FFR decision-making strategy for revascularisation could increase adoption of physiology-guided PCI, by more than halving the need for vasodilator administration, whilst maintaining high classification agreement with an FFR-only strategy.
Sen S, Nijjer S, Petraco R, et al., 2013, THE EFFECT OF ADENOSINE ON CORONARY MICROVASCULAR RESISTANCE IS MORE CONSISTENT DURING THE DIASTOLIC WAVE–FREE PERIOD: SHOULD WE CONTINUE TO USE THE COMPLETE CARDIAC CYCLE FOR STENOSIS ASSESSMENT?, ISSN: 0735-1097
Petraco da Cunha R, Park JJ, Sen S, et al., 2013, A HYBRID DECISION-MAKING STRATEGY WITH INSTANTANEOUS WAVE-FREE RATIO AND FRACTIONAL FLOW RESERVE COULD ENHANCE ADOPTION OF PHYSIOLOGY-GUIDED CORONARY REVASCULARISATION, ISSN: 0735-1097
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