Imperial College London

ProfessorJohnPepper

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiothoracic Surgery
 
 
 
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Contact

 

+44 (0)20 7351 8530j.pepper

 
 
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Location

 

Dept. of SurgeryBritten WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

492 results found

Goodman H, Davison J, Preedy M, Peters E, Waters P, Persaud-Rai B, Shuldham C, Peppers J, Cowie MRet al., 2009, Patient and staff perspective of a nurse-led support programme for patients waiting for cardiac surgery: Participant perspective of a cardiac support programme, EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING, Vol: 8, Pages: 67-73, ISSN: 1474-5151

Journal article

Cheng D, Pepper J, Martin J, Stanbridge R, Ferdinand FD, Jamieson WRE, Stelzer P, Berg G, Sani Get al., 2009, Stentless versus stented bioprosthetic aortic valves: a systematic review and meta-analysis of controlled trials., Innovations (Phila), Vol: 4, Pages: 61-73, ISSN: 1556-9845

OBJECTIVE: : This meta-analysis sought to determine whether stentless bioprosthetic valves improve clinical and resource outcomes compared with stented valves in patients undergoing aortic valve replacement. METHODS: : A comprehensive search was undertaken to identify all randomized and nonrandomized controlled trials comparing stentless to stented bioprosthetic valves in patients undergoing aortic valve replacement available up to March 2008. The primary outcomes were clinical and resource outcomes in randomized controlled trial (RCT). Secondary outcomes clinical and resource outcomes in nonrandomized controlled trial (non-RCT). Odds ratios (OR), weighted mean differences (WMD), or standardized mean differences and their 95% confidence intervals (CI) were analyzed as appropriate. RESULTS: : Seventeen RCTs published in 23 articles involving 1317 patients, and 14 non-RCTs published in 18 articles involving 2485 patients were included in the meta-analysis. For the primary analysis of randomized trials, mortality for stentless versus stented valve groups did not differ at 30 days (OR 1.36, 95% CI 0.68-2.72), 1 year (OR 1.01, 95% CI 0.55-1.85), or 2 to 10 years follow-up (OR 0.82, 95% CI 0.50-1.33). Aggregate event rates for all-cause mortality at 30 days were 3.7% versus 2.9%, at 1 year were 5.5% versus 5.9% and at 2 to 10 years were 17% versus 19% for stentless versus stented valve groups, respectively. Stroke or neurologic complications did not differ between stentless (3.6%) and stented (4.0%) valve groups. Risk of prosthesis-patient mismatch was numerically lower in the stentless group (11.0% vs. 31.3%, OR 0.30, 95% CI 0.05-1.66), but this parameter was reported in few trials and did not reach statistical significance. Effective orifice area index was significantly greater for stentless aortic valve compared with stented valves at 30 days (WMD 0.12 cm/m), at 2 to 6 months (WMD 0.15 cm/m), and at 1 year (WMD 0.26 cm/m). Mean gradient at 1 month was significantly low

Journal article

Pepper J, Cheng D, Stanbridge R, Ferdinand FD, Jamieson WRE, Stelzer P, Berg G, Sani G, Martin Jet al., 2009, Stentless Versus Stented Bioprosthetic Aortic Valves: A Consensus Statement of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS) 2008., Innovations (Phila), Vol: 4, Pages: 49-60, ISSN: 1556-9845

OBJECTIVE: : The purpose of this consensus conference was to determine whether stentless bioprosthetic valves improve clinical and resource outcomes compared with stented valves in patients undergoing aortic valve replacement, and to outline evidence-based recommendations for the use of stentless and stented bioprosthetic valves in adult aortic valve replacement. METHODS: : Before the consensus conference, the best available evidence was reviewed in that systematic reviews, randomized trials, and nonrandomized trials were considered in descending order of validity and importance. At the consensus conference, evidence-based statements were created, and consensus processes were used to determine the ensuing recommendations. The American Heart Association/American College of Cardiology system was used to label the level of evidence and class of recommendation. RESULTS AND RECOMMENDATIONS: : Seventeen randomized studies published in 23 articles involving 1317 patients, and 14 nonrandomized trial published in 18 articles involving 2485 patients were included in the meta-analysis and consensus conference. All randomized trials inserted the stentless bioprosthetic valves in the subcoronary configuration. The consensus panel agreed upon the following statements and recommendations in patients undergoing aortic valve replacement:Because there were no randomized control trial comparing subcoronary stentless prosthetic valve and root replacement, the following recommendations are derived from expert opinion:

Journal article

Ali A, Abu-Omar Y, Patel A, Sheikh AY, Ali Z, Saeed A, Akhtar A, Athanasiou T, Pepper Jet al., 2009, Propensity analysis of survival after subcoronary or root replacement techniques for homograft aortic valve replacement, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 137, Pages: 334-341, ISSN: 0022-5223

Journal article

Murtuza B, Pepper JR, DeL Stanbridge R, Darzi A, Athanasiou Tet al., 2008, Does Minimal-Access Aortic Valve Replacement Reduce the Incidence of Postoperative Atrial Fibrillation?, TEXAS HEART INSTITUTE JOURNAL, Vol: 35, Pages: 428-438, ISSN: 1526-6702

Journal article

Chan KM, Wage R, Symmonds K, Rahman-Haley S, Mohiaddin RH, Firmin DN, Pepper JR, Pennell DJ, Kilner PJet al., 2008, Towards comprehensive assessment of mitral regurgitation using cardiovascular magnetic resonance. Chan KM, Wage, J Cardiovasc Magn Reson., Vol: 22

Journal article

Bjornstad JL, Neverdal NO, Vengen OA, Knudsen CW, Husebye T, Pepper J, Lie M, Christensen G, Tonnessen Tet al., 2008, Alterations in circulating activin A, GDF-15, TGF-β3 and MMP-2,-3, and-9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 10, Pages: 1201-1207, ISSN: 1388-9842

Journal article

Bajraktari G, Duncan A, Pepper J, Henein Met al., 2008, Prolonged total isovolumic time predicts cardiac events following coronary artery bypass surgery, EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, Vol: 9, Pages: 779-783, ISSN: 1525-2167

Journal article

Ali A, Patel A, Abu-Omar Y, Mehta A, Ali Z, Bleiziffer S, Freed D, Sheikh AY, Athanasiou T, Pepper Jet al., 2008, Enhanced Left Ventricular Mass Regression Following Aortic Valve Replacement is Associated with Improved Long-Term Survival: A 15-year Study, 81st Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S788-S788, ISSN: 0009-7322

Conference paper

Ali A, Patel A, Abu-Omar Y, Mehta A, Ail Z, Bleiziffer S, Freed D, Sheikh AY, Athanaslou T, Pepper Jet al., 2008, Comparison Of Long-term Clinical Outcomes Following Aortic Valve Replacement With Homografts And Porcine Stentless Valves, 81st Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S943-S943, ISSN: 0009-7322

Conference paper

Li W, Price S, O'Sullivan CA, Kumar P, Jin XY, Henein MY, Pepper JRet al., 2008, Medium-term outcome of Toronto aortic valve replacement: Single center experience, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 129, Pages: 210-215, ISSN: 0167-5273

Journal article

Goodman H, Parsons A, Davison J, Preedy M, Peters E, Shuldham C, Pepper J, Cowie MRet al., 2008, A randomised controlled trial to evaluate a nurse-led programme of support and lifestyle management for patients awaiting cardiac surgery 'Fit for surgery: Fit for life' study, EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING, Vol: 7, Pages: 189-195, ISSN: 1474-5151

Journal article

Ding W-H, Lam Y-Y, Kaya MG, Li W, Chung R, Pepper JR, Henein MYet al., 2008, Echocardiographic predictors of left ventricular functional recovery following valve replacement surgery for severe aortic stenosis, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 128, Pages: 178-184, ISSN: 0167-5273

Journal article

Booth J, Clayton T, Pepper J, Nugara F, Flather M, Sigwart U, Stables RHet al., 2008, Randomized, controlled trial of coronary artery bypass surgery versus percutaneous coronary intervention in patients with multivessel coronary artery disease - Six-year follow-up from the stent or surgery trial (SoS), CIRCULATION, Vol: 118, Pages: 381-388, ISSN: 0009-7322

Journal article

Ali A, Abu-Omar Y, Patel A, Ali Z, Sheikh AY, Akhtar A, Pavlovic A, Theodorou P, Athanasiou T, Pepper Jet al., 2008, Valve failure following homograft aortic valve replacement: does implantation technique have an effect?, EUROPEAN HEART JOURNAL, Vol: 29, Pages: 1454-1462, ISSN: 0195-668X

Journal article

Lim E, Ali A, Theodorou P, Sousa I, Ashrafian H, Chamageorgakis T, Duncan A, Henein M, Diggle P, Pepper Jet al., 2008, Longitudinal study of the profile and predictors of left ventricular mass regression after stentless aortic valve replacement, ANNALS OF THORACIC SURGERY, Vol: 85, Pages: 2026-2029, ISSN: 0003-4975

Journal article

De Robertis F, Rogers P, Amrani M, Petrou M, Pepper JR, Bahrami T, Dreyfus GD, Khaghani A, Birks EJet al., 2008, Bridge to decision using the levitronix CentriMag short-term ventricular assist device, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 27, Pages: 474-478, ISSN: 1053-2498

Journal article

Murtuza B, Pepper JR, DeL Stanbridge R, Jones C, Rao C, Darzi A, Athanasiou Tet al., 2008, Minimal access aortic valve replacement: Is it worth it?, ANNALS OF THORACIC SURGERY, Vol: 85, Pages: 1121-1131, ISSN: 0003-4975

Journal article

Rao C, Stanbridge RDL, Chikwe J, Pepper J, Skapinakis P, Aziz O, Darzi A, Athanasiou Tet al., 2008, Does previous percutaneous coronary stenting compromise the long-term efficacy of subsequent coronary artery bypass surgery? A microsimulation study, ANNALS OF THORACIC SURGERY, Vol: 85, Pages: 501-507, ISSN: 0003-4975

Journal article

Biglino G, Whitehorne M, Pepper JR, Khir AWet al., 2008, Pressure and flow-volume distribution associated with intra-aortic balloon inflation: An in vitro study, ARTIFICIAL ORGANS, Vol: 32, Pages: 19-27, ISSN: 0160-564X

Journal article

Ali A, Pepper J, 2007, Reoperative surgery on the aortic valve, JOURNAL OF CARDIOVASCULAR SURGERY, Vol: 48, Pages: 791-795, ISSN: 0021-9509

Journal article

John AS, Mongillo M, Depre C, Khan MT, Rimoldi OE, Pepper JR, Dreyfus GD, Pennell DJ, Camici PGet al., 2007, Pre- and post-synaptic sympathetic function in human hibernating myocardium, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 34, Pages: 1973-1980, ISSN: 1619-7070

Journal article

Ali A, Patel A, Freed D, Abu-Omar Y, Sheikh AY, Ali Z, Rostron A, Athanasiou T, Pepper Jet al., 2007, Aortic valve replacement in patients with bicuspid aortic valve disease is not followed by progressive aortic dilatation: A 15-year study, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 448-448, ISSN: 0009-7322

Conference paper

Spatenka J, Mokracek A, Sulda M, Vambera M, Tintera J, Povysil C, Krs O, Pepper Jet al., 2007, Cryopreserved mitral allograft transplantation into tricuspid position in sheep: Preliminary results in one year survivors, TRANSPLANT INTERNATIONAL, Vol: 20, Pages: 100-100, ISSN: 0934-0874

Journal article

Perez De Arenaza D, Flather M, Lees B, Jasinski M, Lie M, Nugara F, Cagide A, Pepper Jet al., 2007, Preoperative 6-minute walk test adds prognostic information to the EuroScore in patients with severe aortic stenosis undergoing aortic valve replacement, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 12-12, ISSN: 0195-668X

Journal article

Perez De Arenaza D, Lees B, Flather D, Lie M, Jasinski M, Nugara F, Krauss J, Pepper Jet al., 2007, Determinants of incomplete left ventricle mass regression after aortic valve replacement: a randomised comparison of stentless vs. stented valves, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 822-823, ISSN: 0195-668X

Journal article

Purcell H, Pepper J, 2007, An arm and a leg to protect the heart?, LANCET, Vol: 370, Pages: 542-543, ISSN: 0140-6736

Journal article

Biglino G, Kolyva C, Whitehorne M, Pepper JR, Khir AWet al., 2007, The effect of shape and angle on intra-aortic balloon pump performance, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, Vol: 30, Pages: 733-733, ISSN: 0391-3988

Journal article

Haj-Yahia S, Birks EJ, Rogers P, Bowles C, Hipkins M, George R, Amrani M, Petrou M, Pepper J, Dreyfus G, Khaghani Aet al., 2007, Midterm experience with the Jarvik 2000 axial flow left ventricular assist device, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 134, Pages: 199-203, ISSN: 0022-5223

Journal article

Stables R, Booth J, Pepper J, Clayton T, Flather M, Nugara F, Sigwart Uet al., 2007, The Stent or Surgery long-term follow-up, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A7-A7, ISSN: 1355-6037

Conference paper

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