Imperial College London
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ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Virtue:2012:10.2337/db12-0015,
author = {Virtue, S and Feldmann, H and Christian, M and Tan, CY and Masoodi, M and Dale, M and Lelliott, C and Burling, K and Campbell, M and Eguchi, N and Voshol, P and Sethi, JK and Parker, M and Urade, Y and Griffin, JL and Cannon, B and Vidal-Puig, A},
doi = {10.2337/db12-0015},
journal = {Diabetes},
pages = {3139--3147},
title = {A new role for lipocalin prostaglandin D synthase in the regulation of brown adipose tissue substrate utilization},
url = {http://dx.doi.org/10.2337/db12-0015},
volume = {61},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this study, we define a new role for lipocalin prostaglandin D synthase (L-PGDS) in the control of metabolic fuel utilization by brown adipose tissue (BAT). We demonstrate that L-PGDS expression in BAT is positively correlated with BAT activity, upregulated by peroxisome proliferator–activated receptor γ coactivator 1α or 1β and repressed by receptor-interacting protein 140. Under cold-acclimated conditions, mice lacking L-PGDS had elevated reliance on carbohydrate to provide fuel for thermogenesis and had increased expression of genes regulating glycolysis and de novo lipogenesis in BAT. These transcriptional differences were associated with increased lipid content in BAT and a BAT lipid composition enriched with de novo synthesized lipids. Consistent with the concept that lack of L-PGDS increases glucose utilization, mice lacking L-PGDS had improved glucose tolerance after high-fat feeding. The improved glucose tolerance appeared to be independent of changes in insulin sensitivity, as insulin levels during the glucose tolerance test and insulin, leptin, and adiponectin levels were unchanged. Moreover, L-PGDS knockout mice exhibited increased expression of genes involved in thermogenesis and increased norepinephrine-stimulated glucose uptake to BAT, suggesting that sympathetically mediated changes in glucose uptake may have improved glucose tolerance. Taken together, these results suggest that L-PGDS plays an important role in the regulation of glucose utilization in vivo.
AU  - Virtue,S
AU  - Feldmann,H
AU  - Christian,M
AU  - Tan,CY
AU  - Masoodi,M
AU  - Dale,M
AU  - Lelliott,C
AU  - Burling,K
AU  - Campbell,M
AU  - Eguchi,N
AU  - Voshol,P
AU  - Sethi,JK
AU  - Parker,M
AU  - Urade,Y
AU  - Griffin,JL
AU  - Cannon,B
AU  - Vidal-Puig,A
DO  - 10.2337/db12-0015
EP  - 3147
PY  - 2012///
SN  - 0012-1797
SP  - 3139
TI  - A new role for lipocalin prostaglandin D synthase in the regulation of brown adipose tissue substrate utilization
T2  - Diabetes
UR  - http://dx.doi.org/10.2337/db12-0015
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000312041700018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://diabetes.diabetesjournals.org/content/61/12/3139
UR  - http://hdl.handle.net/10044/1/82227
VL  - 61
ER  -
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