Imperial College London
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Professor Konstantinos Dimopoulos

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Adult Congenital Heart Disease)
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 82771k.dimopoulos02

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Diller:2015:eurheartj/ehv386,
author = {Diller, G-P and Braeutigam, A and Kempny, A and Uebing, A and Alonso-Gonzalez, R and Swan, L and Babu-Narayan, SV and Baumgartner, H and Dimopoulos, K and Gatzoulis, AA},
doi = {eurheartj/ehv386},
journal = {European Heart Journal},
pages = {771--782},
title = {Depression requiring anti-depressant drug therapy in adult congenital heart disease: prevalence, risk factors, and prognostic value},
url = {http://dx.doi.org/10.1093/eurheartj/ehv386},
volume = {37},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Depression is prevalent in adults with congenital heart disease (ACHD), but limited data on the frequency of anti-depressant drug (ADD) therapy and its impact on outcome are available.Methods and results We identified all ACHD patients treated with ADDs between 2000 and 2011 at our centre. Of 6162 patients under follow-up, 204 (3.3%) patients were on ADD therapy. The majority of patients were treated with selective serotonin-reuptake inhibitors (67.4%), while only 17.0% of patients received tricyclic anti-depressants. Twice as many female patients used ADDs compared with males (4.4 vs. 2.2%, P < 0.0001). The percentage of patients on ADDs increased with disease complexity (P < 0.0001) and patient age (P < 0.0001). Over a median follow-up of 11.1 years, 507 (8.2%) patients died. After propensity score matching, ADD use was found to be significantly associated with worse outcome in male ACHD patients [hazard ratio 1.44 (95% confidence interval 1.17–1.84)]. There was no evidence that this excess mortality was directly related to ADD therapy, QT-prolongation, or malignant arrhythmias. However, males taking ADDs were also more likely to miss scheduled follow-up appointments compared with untreated counterparts, while no such difference in clinic attendance was seen in females.Conclusions The use of ADD therapy in ACHD relates to gender, age, and disease complexity. Although, twice as many female patients were on ADDs, it were their male counterparts, who were at increased mortality risk on therapy. Furthermore, males on ADDs had worse adherence to scheduled appointments suggesting the need for special medical attention and possibly psychosocial intervention for this group of patients.
AU  - Diller,G-P
AU  - Braeutigam,A
AU  - Kempny,A
AU  - Uebing,A
AU  - Alonso-Gonzalez,R
AU  - Swan,L
AU  - Babu-Narayan,SV
AU  - Baumgartner,H
AU  - Dimopoulos,K
AU  - Gatzoulis,AA
DO  - eurheartj/ehv386
EP  - 782
PY  - 2015///
SN  - 1522-9645
SP  - 771
TI  - Depression requiring anti-depressant drug therapy in adult congenital heart disease: prevalence, risk factors, and prognostic value
T2  - European Heart Journal
UR  - http://dx.doi.org/10.1093/eurheartj/ehv386
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371820200014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/43463
VL  - 37
ER  -
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