Publications
36 results found
Bazigou E, Bailey E, Sowinski P, et al., 2014, UNILATERAL NEPHRECTOMY AS A MODEL OF ALTERED BLOOD FLOW FOR THE STUDY OF ARTERIAL PERMEABILITY, Autumn Meeting of the British-Atherosclerosis-Society (BAS), Publisher: ELSEVIER IRELAND LTD, Pages: E4-E5, ISSN: 0021-9150
Zhang J, Chen X, Ding J, et al., 2013, Computational Study of the Blood Flow in Three Types of 3D Hollow Fiber Membrane Bundles, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 135, ISSN: 0148-0731
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- Citations: 12
Poelma C, Fraser KH, 2013, Enhancing the dynamic range of ultrasound imaging velocimetry using interleaved imaging, MEASUREMENT SCIENCE AND TECHNOLOGY, Vol: 24, ISSN: 0957-0233
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- Citations: 12
Zhou B, Fraser KH, Poelma C, et al., 2013, ULTRASOUND IMAGING VELOCIMETRY: EFFECT OF BEAM SWEEPING ON VELOCITY ESTIMATION, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 39, Pages: 1672-1681, ISSN: 0301-5629
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- Citations: 21
Fraser KH, Weinberg PD, 2012, A NUMERICAL STUDY OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ACTIVATION IN AN ARTERIAL BRANCH, ATHEROSCLEROSIS, Vol: 225, Pages: E3-E3, ISSN: 0021-9150
Taskin ME, Zhang T, Fraser KH, et al., 2012, Design Optimization of a Wearable Artificial Pump-Lung Device with Computational Modeling, Journal of Medical Devices-Transactions of the Asme, Vol: 6, ISSN: 1932-619X
The heart-lung machine has commonly been used to replace the functions of both the heart and lungs during open heart surgeries or implemented as extracorporeal membrane oxygenation (ECMO) to provide cardiopulmonary support of the heart and lungs. The traditional heart-lung system consists of multiple components and is bulky. It can only be used for relatively short-term support. The concept of the wearable artificial pump-lung is to combine the functions of the blood pumping and gas transfer in a single, compact unit for cardiopulmonary or respiratory support for patients suffering from cardiac failure or respiratory failure, or both, and to allow patients to be ambulatory. To this end, a wearable artificial lung (APL) device is being developed by integrating a magnetically levitated centrifugal impeller with a hollow fiber membrane bundle. In this study, we utilized a computational fluid dynamics based performance optimization with a heuristic scheme to derive geometrical design parameters for the wearable APL device. The configuration and dimensions of the impeller and the diffuser, the required surface area of fiber membranes and the overall geometrical dimensions of the blood flow path of the APL device were considered. The design optimization was iterated based on the fluid dynamic objective parameters (pressure head, pressure distribution, axial force acting on the impeller, shear stress), blood damage potential (hemolysis and platelet activation), and mass transfer (oxygen partial pressure and saturation). Through the design optimization, an optimized APL device was computationally derived. A physical prototype of the designed APL device was fabricated and tested in vitro. The experimental data showed that the optimized APL can provide adequate blood pumping and oxygen transfer over the range of intended operating conditions.
Zhang J, Zhang P, Fraser KH, et al., 2012, Comparison of fluid dynamic numerical models for a clinical ventricular assist device and experimental validation, Artificial Organs
Fraser KH, Zhang T, Taskin ME, et al., 2012, A quantitative comparison of mechanical blood damage parameters in rotary ventricular assist devices: shear stress, exposure time and hemolysis index., Journal of Biomechanical Engineering-Transactions of the Asme, Vol: 134
Taskin ME, Fraser KH, Zhang T, et al., 2012, Evaluation of Eulerian and Lagrangian Models for Hemolysis Estimation, ASAIO Journal, Vol: 58, Pages: 363-372
Wu ZJ, Taskin ME, Zhang T, et al., 2012, Computational Model-Based Design of a Wearable Artificial Pump-Lung for Cardiopulmonary/Respiratory Support., Artif Organs, Vol: 36, Pages: 387-399
Mechanical ventilation and extracorporeal membrane oxygenation are the only immediate options available for patients with respiratory failure. However, these options present significant shortcomings. To address this unmet need for respiratory support, innovative respiratory assist devices are being developed. In this study, we present the computational model-based design, and analysis of functional characteristics and hemocompatibility performance, of an innovative wearable artificial pump-lung (APL) for ambulatory respiratory support. Computer-aided design and computational fluid dynamics (CFD)-based modeling were utilized to generate the geometrical model and to acquire the fluid flow field, gas transfer, and blood damage potential. With the knowledge of flow field, gas transfer, and blood damage potential through the whole device, design parameters were adjusted to achieve the desired specifications based on the concept of virtual prototyping using the computational modeling in conjunction with consideration of the constraints on fabrication processes and materials. Based on the results of the CFD design and analysis, the physical model of the wearable APL was fabricated. Computationally predicted hydrodynamic pumping function, gas transfer, and blood damage potential were compared with experimental data from in vitro evaluation of the wearable APL. The hydrodynamic performance, oxygen transfer, and blood damage potential predicted with computational modeling, along with the in vitro experimental data, indicated that this APL meets the design specifications for respiratory support with excellent biocompatibility at the targeted operating condition.
Fraser KH, Zhang T, Sorensen E, et al., 2011, Mechanical Blood Damage in an Axial VAD compared to a Centrifugal VAD, NHLBI/VCU-World Congress on Mathematical Modeling and Computational Simulation of Cardiovascular and Cardiopulmonary Dynamics
Fraser KH, Zhang T, Sorensen EN, et al., 2011, Mechanical Blood Damage in an Axial VAD Compared to a Centrifugal VAD, Journal of Heart and Lung Transplantation, Pages: S209-S209
Fraser KH, Taskin ME, Griffith BP, et al., 2011, The use of computational fluid dynamics in the development of ventricular assist devices, Medical Engineering and Physics, Vol: 33, Pages: 263-280
Fraser KH, Zhang T, Griffith BP, et al., 2011, Larger Shear Stresses In Axial VADs Account For Their Increased Hemolysis Risk Compared With Centrifugal VADs, American Society of Artificial Internal Organs
Fraser KH, Zhang T, Griffith BP, et al., 2011, Development, Validation and Application of a Hemolysis Model for Ventricular Assist Devices, FDA / NHLBI / NSF Workshop on Computer Methods for Medical Devices
Fraser KH, Zhang T, Taskin ME, et al., 2010, Computational Fluid Dynamics Analysis of Thrombosis Potential in Left Ventricular Assist Device Drainage Cannulae, ASAIO Journal, Vol: 56, Pages: 157-163
Fraser KH, Taskin ME, Zhang T, et al., 2010, Comparison of Shear Stress, Residence Time and Lagrangian Estimates of Hemolysis in Different Ventricular Assist Devices, 26th Southern Biomedical Engineering Conference, Pages: 548-551
Taskin ME, Fraser KH, Zhang T, et al., 2010, Micro-scale modeling of flow and oxygen transfer in hollow-fiber membrane bundle, Journal of Membrane Science, Vol: 362, Pages: 172-183
Fraser KH, Taskin ME, Zhang T, et al., 2010, THE EFFECT OF IMPELLER POSITION ON CFD CALCULATIONS OF BLOOD FLOW IN MAGNETICALLY LEVITATED CENTRIFUGAL BLOOD PUMPS, New York, Proceedings of the Asme Summer Bioengineering Conference, 2010, Publisher: Amer Soc Mechanical Engineers, Pages: 119-120
Taskin ME, Fraser KH, Zhang T, et al., 2010, Computational Characterization of Flow and Hemolytic Performance of the UltraMag Blood Pump for Circulatory Support, Artif Organs, Vol: 34, Pages: 1099-1113
Fraser KH, Taskin ME, Zhang T, et al., 2010, Comparison of Shear Stresses and Residence Times in Different Ventricular Assist Devices, FDA / NHLBI / NSF Workshop on Computer Methods for Cardiovascular Devices
Fraser KH, Zhang T, Taskin ME, et al., 2010, Design of a New Magnetically Levitated Hemolyzer using CFD, American Society of Artificial Internal Organs
Fraser KH, Taskin ME, Zhang T, et al., 2010, A Validated Numerical Model for Haemolysis in Different Ventricular Assist Devices, 17th Congress of the European Society of Biomechanics
Fraser KH, Taskin ME, Zhang T, et al., 2009, Influence of Taylor Vortices in Centrifugal Ventricular Assist Devices on Blood Damage Potential, FDA / NHLBI / NSF Workshop on Computer Methods for Cardiovascular Devices
Fraser KH, Mihelc K, Gellman B, et al., 2009, CFD Analysis of Thrombosis Potential in LVAD Drainage Cannulae, American Society of Artificial Internal Organs
Fraser KH, Li MX, Lee WT, et al., 2009, Fluid-structure interaction in axially symmetric models of abdominal aortic aneurysms, Proceedings of the Institution of Mechanical Engineers. Part H: Journal of Engineering in Medicine, Vol: 223, Pages: 195-209
Blake JR, Meagher S, Fraser KH, et al., 2008, A method to estimate wall shear rate with a clinical ultrasound scanner, Ultrasound in Medicine and Biology, Vol: 34, Pages: 760-774
Fraser KH, Meagher S, Blake JR, et al., 2008, Characterization of an abdominal aortic velocity waveform in patients with abdominal aortic aneurysm, Ultrasound in Medicine and Biology, Vol: 34, Pages: 73-80
Fraser KH, Li M, Lee WT, et al., 2007, Fluid Structure Interactions in Simple Abdominal Aortic Aneurysms, Physiological Flow Network
Fraser KH, Poepping TL, McNeilly A, et al., 2006, Acoustic speed and attenuation coefficient in sheep aorta measured at 5-9 MHz, Ultrasound in Medicine and Biology, Vol: 32, Pages: 971-980
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