Imperial College London
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ProfessorKatharinaHauck

Faculty of Medicine, School of Public Health

Professor in Health Economics
 
 
 
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Contact

 

+44 (0)20 7594 9197k.hauck Website

 
 
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Assistant

 

Ms Julie Middleton +44 (0)20 7594 3284

 
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Location

 

Office 502School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davis:2023:10.1016/j.ssmph.2023.101473,
author = {Davis, K and Pickles, M and Gregson, S and Hargreaves, JR and Ayles, H and Bock, P and Pliakas, T and Thomas, R and Ohrnberger, J and Bwalya, J and Bell-Mandla, N and Shanaube, K and Probert, W and Hoddinott, G and Bond, V and Hayes, R and Fidler, S and Hauck, K},
doi = {10.1016/j.ssmph.2023.101473},
journal = {SSM: Population Health},
pages = {1--10},
title = {The effect of universal testing and treatment for HIV on health-related quality of life – an analysis of data from the HPTN 071 (PopART) cluster randomised trial},
url = {http://dx.doi.org/10.1016/j.ssmph.2023.101473},
volume = {23},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundHIV treatment has clear Health-Related Quality-of-Life (HRQoL) benefits. However, little is known about how Universal Testing and Treatment (UTT) for HIV affects HRQoL. This study aimed to examine the effect of a combination prevention intervention, including UTT, on HRQoL among People Living with HIV (PLHIV).MethodsData were from HPTN 071 (PopART), a three-arm cluster randomised controlled trial in 21 communities in Zambia and South Africa (2013–2018). Arm A received the full UTT intervention of door-to-door HIV testing plus access to antiretroviral therapy (ART) regardless of CD4 count, Arm B received the intervention but followed national treatment guidelines (universal ART from 2016), and Arm C received standard care. The intervention effect was measured in a cohort of randomly selected adults, over 36 months. HRQoL scores, and the prevalence of problems in five HRQoL dimensions (mobility, self-care, performing daily activities, pain/discomfort, anxiety/depression) were assessed among all participants using the EuroQol-5-dimensions-5-levels questionnaire (EQ-5D-5L). We compared HRQoL among PLHIV with laboratory confirmed HIV status between arms, using adjusted two-stage cluster-level analyses.ResultsAt baseline, 7,856 PLHIV provided HRQoL data. At 36 months, the mean HRQoL score was 0.892 (95% confidence interval: 0.887–0.898) in Arm A, 0.886 (0.877–0.894) in Arm B and 0.888 (0.884–0.892) in Arm C. There was no evidence of a difference in HRQoL scores between arms (A vs C, adjusted mean difference: 0.003, -0.001-0.006; B vs C: -0.004, -0.014-0.005). The prevalence of problems with pain/discomfort was lower in Arm A than C (adjusted prevalence ratio: 0.37, 0.14–0.97). There was no evidence of differences for other HRQoL dimensions.ConclusionsThe intervention did not change overall HRQoL, suggesting that raising HRQoL among PLHIV might require more than improved testing and treatment. However, PLHIV had fewer problems with p
AU  - Davis,K
AU  - Pickles,M
AU  - Gregson,S
AU  - Hargreaves,JR
AU  - Ayles,H
AU  - Bock,P
AU  - Pliakas,T
AU  - Thomas,R
AU  - Ohrnberger,J
AU  - Bwalya,J
AU  - Bell-Mandla,N
AU  - Shanaube,K
AU  - Probert,W
AU  - Hoddinott,G
AU  - Bond,V
AU  - Hayes,R
AU  - Fidler,S
AU  - Hauck,K
DO  - 10.1016/j.ssmph.2023.101473
EP  - 10
PY  - 2023///
SN  - 2352-8273
SP  - 1
TI  - The effect of universal testing and treatment for HIV on health-related quality of life – an analysis of data from the HPTN 071 (PopART) cluster randomised trial
T2  - SSM: Population Health
UR  - http://dx.doi.org/10.1016/j.ssmph.2023.101473
UR  - https://www.sciencedirect.com/science/article/pii/S2352827323001386
UR  - http://hdl.handle.net/10044/1/105688
VL  - 23
ER  -
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