Imperial College London
Alternate

Professor Kazuhiro Ito

Faculty of Medicine, National Heart & Lung Institute

Principal Research Fellow in Respiratory Molecular Pharmacol
 
 
 
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Contact

 

+44 (0)20 7594 0953k.ito Website

 
 
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Location

 

412Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Adcock:2005:10.1513/pats.200504-035SR,
author = {Adcock, IM and Ito, K},
doi = {10.1513/pats.200504-035SR},
journal = {Proc Am Thorac Soc},
pages = {313--319},
title = {Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.},
url = {http://dx.doi.org/10.1513/pats.200504-035SR},
volume = {2},
year = {2005}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Lung function measures in patients with chronic obstructive pulmonary disease remain insensitive to corticosteroid actions, in contrast to the clinical improvements observed in most patients with asthma. By uncovering the reason for this paradox, physicians should be able to implement treatment regimens that restore corticosteroid sensitivity. Corticosteroids exert their effects by binding to a cytoplasmic glucocorticoid receptor, which is subjected to post-translational modification by phosphorylation. Receptor phosphorylation may influence hormone binding and nuclear translocation, as well as alter other glucocorticoid receptor interactions, its protein half-life, and downregulation processes. This suggests that a "phosphorylation code" may exist for glucocorticoid receptor function. Oxidative stress due to cigarette smoke may also be a mechanism for the corticosteroid resistance observed in chronic obstructive pulmonary disease, as it enhances proinflammatory transcription. Reduced glucocorticoid nuclear translocation along with attenuated histone deacetylase activity may be partially responsible for this effect. Therapies targeting these aspects of the glucocorticoid receptor activation pathway may reverse steroid resistance in patients with chronic obstructive pulmonary disease.
AU  - Adcock,IM
AU  - Ito,K
DO  - 10.1513/pats.200504-035SR
EP  - 319
PY  - 2005///
SN  - 1546-3222
SP  - 313
TI  - Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.
T2  - Proc Am Thorac Soc
UR  - http://dx.doi.org/10.1513/pats.200504-035SR
UR  - https://www.ncbi.nlm.nih.gov/pubmed/16267355
VL  - 2
ER  -
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