Imperial College London
Alternate

Professor Kazuhiro Ito

Faculty of Medicine, National Heart & Lung Institute

Principal Research Fellow in Respiratory Molecular Pharmacol
 
 
 
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Contact

 

+44 (0)20 7594 0953k.ito Website

 
 
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Location

 

412Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Katsumata:2013:10.1007/s10165-012-0624-y,
author = {Katsumata, Y and Kawaguchi, Y and Baba, S and Hattori, S and Tahara, K and Ito, K and Iwasaki, T and Yamaguchi, N and Hattori, H and Nagata, K and Okamoto, Y and Yamanaka, H and Hara, M},
doi = {10.1007/s10165-012-0624-y},
journal = {Mod Rheumatol},
pages = {71--80},
title = {Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study.},
url = {http://dx.doi.org/10.1007/s10165-012-0624-y},
volume = {23},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: We assessed the association between serum autoantibodies against the 70-kDa polypeptide of the U1-ribonucleoprotein (RNP) complex (U1-70k) and the central nervous system (CNS) syndromes in systemic lupus erythematosus (SLE) patients. METHODS: We studied 106 hospitalized patients with active SLE, comparing those with (n = 32) and without (n = 74) CNS syndromes. CNS syndromes were further classified into neurologic (n = 21) and psychiatric (n = 15) disorders. Immunoglobulin G (IgG) anti-U1-70k antibodies were measured by enzyme-linked immunosorbent assay (ELISA) using recombinant antigens. IgG antibodies against whole U1-RNP were measured using commercial ELISA kits. RESULTS: Although there was no significant difference in the levels of serum anti-U1-70k antibodies in SLE patients with or without CNS syndromes (p = 0.83), the levels were significantly elevated in SLE patients compared with patients without psychiatric syndromes (p = 0.030). In contrast, no significant difference was observed in the levels of serum anti-U1-RNP antibodies in SLE patients with or without psychiatric syndromes (p = 0.555). CONCLUSIONS: These results indicate that serum anti-U1-70k antibodies are associated with psychiatric syndromes in SLE but that they are not associated with CNS syndromes as a whole or with neurologic syndromes. The anti-U1-70k antibodies might be involved in the pathological mechanisms of psychiatric syndromes in SLE.
AU  - Katsumata,Y
AU  - Kawaguchi,Y
AU  - Baba,S
AU  - Hattori,S
AU  - Tahara,K
AU  - Ito,K
AU  - Iwasaki,T
AU  - Yamaguchi,N
AU  - Hattori,H
AU  - Nagata,K
AU  - Okamoto,Y
AU  - Yamanaka,H
AU  - Hara,M
DO  - 10.1007/s10165-012-0624-y
EP  - 80
PY  - 2013///
SP  - 71
TI  - Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study.
T2  - Mod Rheumatol
UR  - http://dx.doi.org/10.1007/s10165-012-0624-y
UR  - https://www.ncbi.nlm.nih.gov/pubmed/22454191
VL  - 23
ER  -
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