Publications
422 results found
Amare PS, Varghese C, Bharde SH, et al., 2001, Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7, CANCER GENETICS AND CYTOGENETICS, Vol: 125, Pages: 139-146, ISSN: 0165-4608
- Author Web Link
- Cite
- Citations: 16
Naresh KN, Lakshminarayanan K, Pai SA, et al., 2001, Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue: A hypothesis to support this paradoxical association, Cancer, Vol: 91, Pages: 578-584, ISSN: 0008-543X
BACKGROUND. Patients with squamous carcinoma of the oral tongue in clinical stages T1N0M0 and T2N0M0 with a tumor thickness ≤ 3 mm usually do not have lymph node (LN) metastasis. However, factors that are useful in predicting LN metastasis in thicker tumors (> 3 mm thick) need to be identified. The authors investigated the clinical relevance of the apoptotic index (AI), the proliferation index, and tumor grade in relation to LN metastasis in patients with early stage squamous carcinoma of the oral tongue. METHODS. Twenty-three patients with squamous carcinoma of the anterior two-thirds of the tongue measuring < 2 cm in height and > 3 mm in thickness were evaluated for tumor grade, AI (by using the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling technique), and proliferation index (by proliferating cell nuclear antigen [PCNA] expression). RESULTS. The mean AI value was significantly higher in LN positive patients compared with LN negative patients (P = 0.012). The LN positive and LN negative subgroups did not differ in the mean PCNA index, and there was no significant difference in the distributions of tumor grade between LN positive and LN negative subsets. Four of 12 tumors with an AI ≤ 5% and 10 of 11 tumors with an AI > 5% had LN metastasis (P = 0.009; risk ratio, 20). The AI maintained its significance with respect to LN metastasis in the multivariate analysis (P = 0.003). The 4-year recurrence free survival was significantly better in patients with tumors that had an AI value ≤ 5% compared with patients with tumors that had an AI > 5% (92% vs, 32%) (P = 0.033). However, the AI lost its impact on recurrence free survival within a Cox proportional hazards model (P = 0.068). CONCLUSIONS. A higher AI value is a predictor of LN metastasis and may serve as a prognostic factor in patients with early stage squamous carcinoma of the oral tongue. The authors present a hypothesis to explain this rather surprising finding. &cop
Naresh KN, Lakshminarayanan K, Pai SA, et al., 2001, Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue -: <i>A hypothesis to support this paradoxical association</i>, CANCER, Vol: 91, Pages: 578-584, ISSN: 0008-543X
- Author Web Link
- Cite
- Citations: 46
Metkar SS, Manna PP, Anand M, et al., 2001, CD40 ligand - An anti-apoptotic molecule in Hodgkin's disease, CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, Vol: 16, Pages: 85-92, ISSN: 1084-9785
- Author Web Link
- Cite
- Citations: 10
Kapur B, Nair R, Gopal R, et al., 2000, Primary cardiac lymphoma, Indian Journal of Hematology and Blood Transfusion, Vol: 18, ISSN: 0971-4502
Primary cardiac lymphoma is a rare disease. We report a case of lymphoma of right and ventricle who was treated with multimodality treatment and remains in complete remission 18 months after treatment completion.
Metkar SS, Naresh KN, Manna PP, et al., 2000, Circulating levels of TNFα and TNF receptor superfamily members in lymphoid neoplasia, American Journal of Hematology, Vol: 65, Pages: 105-110, ISSN: 0361-8609
We have correlated the serum levels of TNFα and soluble TNF receptor superfamily members with clinico-pathologic parameters in patients of Hodgkin's disease (HD, N = 26) and non-Hodgkin's lymphoma (NHLs, N = 35). HD patients had significantly higher levels of TNFα, sTNFRI, and sTNFRII in serum while NHL patients had significantly higher levels of sTNFRI, sTNFRII, sCD27, and sFas as compared to controls. In NHL patients the levels of sCD27 correlated directly and significantly with the high-stage disease, bone marrow involvement, lymph nodal presentation, and serum LDH levels. Similarly in NHL patients, levels of sFas also correlated directly and significantly with the presence of high stage disease. HD patients with B symptoms had significantly higher levels of sTNFRII. (C) 2000 Wiley-Liss, Inc.
Metkar SS, Naresh KN, Manna PP, et al., 2000, Circulating levels of TNFα and TNF receptor superfamily members in lymphoid neoplasia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 65, Pages: 105-110, ISSN: 0361-8609
- Author Web Link
- Cite
- Citations: 14
Desai SB, Moonim MT, Gill AK, et al., 2000, Hormone receptor status of breast cancer in India: a study of 798 tumours, BREAST, Vol: 9, Pages: 267-270, ISSN: 0960-9776
- Author Web Link
- Cite
- Citations: 68
Naresh KN, 2000, Can clinicians afford to ignore molecular medicine?, NATIONAL MEDICAL JOURNAL OF INDIA, Vol: 13, Pages: 225-227, ISSN: 0970-258X
Borges AM, Naresh KN, 2000, The adhesion molecule expression pattern of basal cell carcinoma cells should be compared with outer root sheath cells of hair follicle and NOT with stratum basale of skin, HUMAN PATHOLOGY, Vol: 31, Pages: 1181-1181, ISSN: 0046-8177
Naresh KN, 2000, Proliferation center cells in the lymph nodes of B-cell chronic lymphatic leukemia express relatively higher levels of CD20, HUMAN PATHOLOGY, Vol: 31, Pages: 775-775, ISSN: 0046-8177
- Author Web Link
- Cite
- Citations: 1
Vaideeswar P, Madiwale CV, Desai AP, et al., 2000, Inflammatory pseudotumour of the lymph node in an HIV-positive individual, HISTOPATHOLOGY, Vol: 36, Pages: 374-375, ISSN: 0309-0167
- Author Web Link
- Cite
- Citations: 4
Nerurkar AY, Vijayan P, Srinivas V, et al., 2000, Discrepancies in Epstein-Barr virus association at presentation and relapse of classical Hodgkin's disease: Impact on pathogenesis, ANNALS OF ONCOLOGY, Vol: 11, Pages: 475-478, ISSN: 0923-7534
- Author Web Link
- Cite
- Citations: 24
Metkar SS, Anand M, Manna PP, et al., 2000, Ceramide-induced apoptosis in Fas-resistant Hodgkin's disease cell lines is caspase independent, EXPERIMENTAL CELL RESEARCH, Vol: 255, Pages: 18-29, ISSN: 0014-4827
- Author Web Link
- Cite
- Citations: 12
Naresh KN, Srinivas V, Soman CS, 2000, Distribution of various subtypes of non-Hodgkin's lymphoma in India: A study of 2773 lymphomas using R.E.A.L. and WHO classifications, ISSN: 0923-7534
Introduction: The distribution of the major subtypes of non-Hodgkin's lymphoma (NHL) differs across geographic regions. This is the first study from India that has incorporated immunophenotypic findings while investigating the distribution of NHL subtypes. Patients and methods: All cases diagnosed as NHL between January 1995 and June 1998 in the Department of Pathology and in the Lymphoma Registry, Tata Memorial Hospital, Bombay, were selected for the study. The cases were reviewed by three pathologists and diagnostic problems were discussed by a panel of pathologists with a special interest in lymph node pathology. Of a total of 2831 cases, the diagnosis of NHL was accepted in 2773 cases. Results: B-cell lymphomas formed 79.1% of the NHLs, whereas T-cell lymphomas formed 16.2% of the total. Diffuse large B-cell lymphoma was the most common subtype (34% of all NHLs). Follicular centre-cell lymphomas, B-cell small lymphocytic lymphoma, mantle- cell lymphoma, and marginal zone B-cell lymphomas (including MALT lymphomas) amounted to 12.6%, 5.7%, 3.4%, and 8.2%, respectively. Among the T-cell lymphomas, T-cell lymphoblastic lymphoma, anaplastic large-cell lymphomas of T/null-cell type, and other nodal peripheral T-cell lymphomas accounted for 6%, 4.3%, and 2.9% of all cases, respectively. Conclusions: The distribution of NHL subtypes in India shows important differences with those from the rest of the world. Follicular lymphoma and mantle-cell lymphoma are less common in India compared to Europe and the USA. Peripheral T-cell lymphomas and T/NK- cell lymphomas of nasal and nasal types, which are common in many other Asian countries, are also less prevalent. T-cell lymphoblastic lymphoma and anaplastic large T/null cell lymphoma are more prevalent in India.
Naresh KN, 2000, B-cell anaplastic large cell lymphoma - The forgotten entity, AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Vol: 24, Pages: 159-160, ISSN: 0147-5185
- Author Web Link
- Cite
- Citations: 1
Naresh KN, Johnson J, Srinivas V, et al., 2000, Epstein-Barr virus association in classical Hodgkin's disease provides survival advantage to patients and correlates with higher expression of proliferation markers in Reed-Sternberg cells, ANNALS OF ONCOLOGY, Vol: 11, Pages: 91-96, ISSN: 0923-7534
- Author Web Link
- Cite
- Citations: 62
Desai KI, Nadkarni TD, Goel A, et al., 2000, Primary Ewing's sarcoma of the cranium, NEUROSURGERY, Vol: 46, Pages: 62-68, ISSN: 0148-396X
- Author Web Link
- Cite
- Citations: 70
Singh A, Thapar V, Prabhu R, et al., 2000, Isolated splenic lymphoma: an elusive preoperative diagnosis., Indian J Gastroenterol, Vol: 19, Pages: 184-186, ISSN: 0254-8860
Four patients underwent splenectomy for various clinical and radiological diagnoses and were found to have primary splenic lymphoma at surgery and histology. The diagnosis was classical Hodgkin's lymphoma, mixed cellularity type (one case); marginal zone B-cell non-Hodgkin's lymphoma (one case); and large B cell type non-Hodgkin's lymphoma (two cases). The first two patients had multiple nodules in the spleen measuring 0.1-0.5 cm while large cell lymphomas had large nodules (largest measuring 11 cm x 7 cm x 4 cm). The diagnoses were confirmed by immunohistochemical analysis. Mean follow up of these patients was 11 months; all patients received chemotherapy. One patient died, of causes not related to the disease process.
Perambakam S, Naresh K, Nerurkar A, et al., 2000, Intra-tumoral cytolytic cells: pattern of distribution in B-cell non Hodgkin s lymphoma., Pathol Oncol Res, Vol: 6, Pages: 114-117, ISSN: 1219-4956
Non-Hodgkin s lymphomas (NHLs) constitute a heterogeneous group of lymphoid neoplasms and a majority of them in India are of B-cell phenotype. Varying numbers of T lymphocytes and natural killer (NK) cells are consistently present within the lymph nodes (LNs). The role of these reactive cells is becoming understood. TIA-1 is a cytotoxic granule associated RNA binding protein, the expression of which is restricted to cytotoxic T lymphocytes (CTLs) and NK cells. Snap frozen lymph node biopsies obtained from 41 B-cell NHLs were localized for intra-tumoral TIA-1 + cytolytic cells by immunohistochemistry. Distribution of T cell subsets and NK cells were also quantified. Cells expressing TIA-1 antigen was observed in all the cases, seen as a strong granular cytoplasmic signal. Results indicate significantly higher number of TIA-1 cytolytic cells outside (periphery of the follicle and interfollicular areas) than within the neoplastic follicle in follicular lymphomas (p<0.001). In small lymphocytic lymphomas, cytolytic cells were mainly seen as uniformly scattered single cells, distributed throughout the tumor environment. In mantle cell and diffuse large B-cell lymphomas these were most often seen as small clusters and less frequently as singly scattered cells. Higher numbers of CD4 + than the CD8 + T cells were observed in most cases. Contrary to the follicles in follicular hyperplasia, CD57 + NK cells were predominantly observed outside the neoplastic follicle in follicular lymphomas (FLs). These results outline specific interactions between the potential anti-tumoral cytolytic and the malignant cells of B-cell NHLs.
Naresh KN, Srinivas V, Soman CS, 2000, Distribution of various subtypes of non-Hodgkin's lymphoma in India: A study of 2773 lymphomas using REAL and WHO Classifications, ANNALS OF ONCOLOGY, Vol: 11, Pages: 63-67, ISSN: 0923-7534
- Author Web Link
- Cite
- Citations: 105
Gupte S, Nair R, Naresh KN, et al., 1999, MALT lymphoma of nasal mucosa treated with antibiotics, LEUKEMIA & LYMPHOMA, Vol: 36, Pages: 195-197, ISSN: 1042-8194
- Author Web Link
- Cite
- Citations: 9
Quintanilla-Martinez L, Franklin JL, Guerrero I, et al., 1999, Histological and immunophenotypic profile of nasal NK T cell lymphomas from Peru: High prevalence of p53 overexpression, HUMAN PATHOLOGY, Vol: 30, Pages: 849-855, ISSN: 0046-8177
- Author Web Link
- Cite
- Citations: 94
Metkar SS, Naresh KN, Redkar AA, et al., 1999, Expression of Fas and Fas ligand in Hodgkin's disease, LEUKEMIA & LYMPHOMA, Vol: 33, Pages: 521-+, ISSN: 1042-8194
- Author Web Link
- Cite
- Citations: 32
Thomas SM, Naresh KN, Wagle AS, et al., 1998, Preclinical studies on suicide gene therapy for Head/Neck cancer: A novel method for evaluation of treatment efficacy, Anticancer Research, Vol: 18, Pages: 4393-4398, ISSN: 0250-7005
Background: Malignancies of the oral cavity and oropharynx account for 31% of all diagnosed cancers in India. In most cases, patients present with tumours that are clinically stage III/IV where surgery, radiotherapy and chemotherapy have not been very effective. Hence, there is an urgent need for alternate treatment modalities. Gene therapy is a recent development shown to be effective in various malignancies. In this study we have attempted to cause bulk reduction in tumour volume using the HSVtk/ganciclovir strategy, solely on the basis of the 'bystander' effect. Methods: Nude mouse xenograft tumours of human head/neck cancer were engrafted with cells expressing viral thymidine kinase. After treatment with 8 mM ganciclovir for 14 days, the treatment efficacy was monitored. A novel method has been devised to evaluate cell kill microscopically in the whole tumour. Results: Of the 11 mice included in the study, 9 showed a significant reduction in total tumour volume of treated versus control tumours (p = 0.015). Conclusions: Bulk reduction in tumour load can be brought about without use of viral vectors for gene transfer solely by the bystander effect.
Thomas SM, Naresh KN, Wagle AS, et al., 1998, Preclinical studies on suicide gene therapy for head/neck cancer: A novel method for evaluation of treatment efficacy, ANTICANCER RESEARCH, Vol: 18, Pages: 4393-4398, ISSN: 0250-7005
- Author Web Link
- Cite
- Citations: 13
Nanjangud G, Naresh KN, Nair CN, et al., 1998, Translocation (11;14)(q13;q32) and overexpression of cyclin D1 protein in a CD23-positive low-grade B-cell neoplasm, CANCER GENETICS AND CYTOGENETICS, Vol: 106, Pages: 37-43, ISSN: 0165-4608
- Author Web Link
- Cite
- Citations: 5
Metkar SS, Naresh KN, Redkar AA, et al., 1998, CD40-ligation-mediated protection from apoptosis of a Fas-sensitive Hodgkin's-disease-derived cell line, CANCER IMMUNOLOGY IMMUNOTHERAPY, Vol: 47, Pages: 104-112, ISSN: 0340-7004
- Author Web Link
- Cite
- Citations: 19
Pai SA, Naresh KN, Soman CS, et al., 1998, Pseudolymphomatous phase of Kikuchi-Fujimoto disease., Indian J Cancer, Vol: 35, Pages: 119-128, ISSN: 0019-509X
Kikuchi-Fujimoto lymphadenitis is a distinctive entity which is easily recognised in its classical histology. However, cases which are biopsied in the early stage of the disease, before entering the necrotic phase may be misdiagnosed as non-Hodgkin's lymphoma. Ten cases of Kikuchi-Fujimoto disease which mimicked non-Hodgkin's lymphoma and in which less than 10% of the lymph node was occupied by necrosis were chosen for this study. The patients included 4 males and 6 females with an age range of 15-40 years. Eight patients presented with cervical lymphadenopathy. The pathologic areas ranged from 70% to 95% of the total nodal area. The features that helped distinguish this lesion from non-Hodgkin's lymphoma were: 1) a sprinkling of karyorrhectic debris throughout the node 2) plasmacytoid monocytes as well as "histiocytes" in the company of transformed lymphocytes (immunoblasts) 3) enlarged mottled T-zone areas, and 4) presence of residual lymphoid follicles. Follow up on six patients revealed no evidence of disease.
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.