Imperial College London
Professor Kim Parker

Professor Kim Parker

Faculty of Engineering, Department of Bioengineering

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 5171k.parker Website

 
 
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Location

 

4.29Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sluyter:2016:10.1016/j.ijcard.2016.06.051,
author = {Sluyter, JD and Hughes, AD and Lowe, A and Parker, KH and Camargo, CA and Hametner, B and Wassertheurer, S and Scragg, RKR},
doi = {10.1016/j.ijcard.2016.06.051},
journal = {International Journal of Cardiology},
pages = {257--263},
title = {Different associations between beta-blockers and other antihypertensive medication combinations with brachial blood pressure and aortic waveform parameters},
url = {http://dx.doi.org/10.1016/j.ijcard.2016.06.051},
volume = {219},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundComparing the relationships of antihypertensive medications with brachial blood pressure (BP) and aortic waveform parameters may help clinicians to predict the effect on the latter in brachial BP-based antihypertensive therapy. We aimed to make such comparisons with new waveform measures and a wider range of antihypertensive regimens than examined previously.MethodsCross-sectional analysis of 2933 adults (61% male; aged 50–84 years): 1637 on antihypertensive treatment and 1296 untreated hypertensives. Sixteen medicine regimens of up to 4 combinations of drugs from 6 antihypertensive classes were analysed. Aortic systolic BP, augmentation index (AIx), excess pressure integral (EPI), backward pressure amplitude (Pb), reflection index (RI) and pulse wave velocity (PWV) were calculated from aortic pressure waveforms derived from suprasystolic brachial measurement.ResultsForest plots of single-drug class comparisons across regimens with the same number of drugs (for between 1- and 3-drug regimens) revealed that AIx, Pb, RI and/or loge(EPI) were higher (maximum difference = 5.6%, 2.2 mm Hg, 0.0192 and 0.13 loge(mm Hg ⋅ s), respectively) with the use of a beta-blocker compared with vasodilators and diuretics, despite no brachial systolic and diastolic BP differences. These differences were reduced (by 34–57%) or eliminated after adjustment for heart rate, and similar effects occurred when controlling for systolic ejection period or diastolic duration.ConclusionsBeta-blocker effects on brachial BP may overestimate effects on aortic waveform parameters. Compared to other antihypertensives, beta-blockers have weaker associations with wave reflection measures and EPI; this is predominantly due to influences on heart rate.
AU  - Sluyter,JD
AU  - Hughes,AD
AU  - Lowe,A
AU  - Parker,KH
AU  - Camargo,CA
AU  - Hametner,B
AU  - Wassertheurer,S
AU  - Scragg,RKR
DO  - 10.1016/j.ijcard.2016.06.051
EP  - 263
PY  - 2016///
SN  - 1874-1754
SP  - 257
TI  - Different associations between beta-blockers and other antihypertensive medication combinations with brachial blood pressure and aortic waveform parameters
T2  - International Journal of Cardiology
UR  - http://dx.doi.org/10.1016/j.ijcard.2016.06.051
UR  - http://hdl.handle.net/10044/1/40286
VL  - 219
ER  -
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