Imperial College London
Alternate

Emeritus ProfessorKimFox

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 7966kim.fox

 
 
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Assistant

 

Ms Deborah Curcher +44 (0)20 7594 7966

 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

565 results found

Purcell H, Dalby M, Sheppard M, Fox Ket al., 1999, Unstable angina and its causes, Symposium on Key Advances in the Effective Management of Unstable Angina, Publisher: ROYAL SOC MEDICINE PRESS LTD, Pages: 1-5

Conference paper

Saia F, Chua TP, Fox KM, 1998, The management of hypercholesterolaemia in patients with coronary artery disease referred for coronary angiography, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 67, Pages: 247-249, ISSN: 0167-5273

Journal article

Gunning MG, Anagnostopoulos C, Knight CJ, Pepper J, Burman ED, Davies G, Fox KM, Pennell DJ, Ell PJ, Underwood SRet al., 1998, Comparison of <SUP>201</SUP>Tl, <SUP>99m</SUP>Tc-tetrofosmin, and dobutamine magnetic resonance imaging for identifying hibernating myocardium, CIRCULATION, Vol: 98, Pages: 1869-1874, ISSN: 0009-7322

Journal article

Antman EM, McCabe CH, Premmereur J, Gurfinkel E, Bernink PJLM, Turpie AGG, de Luna AB, LaBlanche JM, Fox KM, Salein D, Radley DR, Braunwald Eet al., 1998, Enoxaparin for the acute and chronic management of unstable angina non-Q wave myocardial infarction: Results of TIMI 11B, CIRCULATION, Vol: 98, Pages: 504-504, ISSN: 0009-7322

Journal article

Holper EM, Antman EM, Mccabe CH, Premmereur J, Gurfinkel E, Bernink PJLM, Turple AGG, de Luna AB, LaBlanche JM, Fox KM, Salein D, Radley DRet al., 1998, A simple, readily available method for risk stratification of patients with unstable angina or non-Q myocardial infarction: A TIMI 11B substudy., CIRCULATION, Vol: 98, Pages: 493-493, ISSN: 0009-7322

Journal article

Chua TP, Pepper JR, Fox KM, 1998, The use of an implantable left ventricular assist device in a patient with cardiogenic shock following acute myocardial infarction, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 66, Pages: 55-58, ISSN: 0167-5273

Journal article

Purcell H, Fox KM, 1998, Current roles and future possibilities for low-molecular-weight heparins in unstable angina, EUROPEAN HEART JOURNAL, Vol: 19, Pages: K18-K23, ISSN: 0195-668X

Journal article

Simoons ML, Vos J, de Feyter PJ, Bots ML, Remme WJ, Grobbee DE, Kluft C, de Maat MPM, Fox KM, Deckers JWet al., 1998, EUROPA substudies, confirmation of pathophysiological concepts, Satellite Symposium on ACE Inhibition and Myocardial Ischaemia - New Challenge for the Third Millennium at the XXth Congress of the European-Society-of-Cardiology, Publisher: OXFORD UNIV PRESS, Pages: J56-J60, ISSN: 0195-668X

Conference paper

Mulcahy D, Gunning M, Knight C, Patel D, Davies M, Underwood R, Sutton G, Clarke D, Wright C, Saia F, Fox Ket al., 1998, Long-term (5 year) effects of transient (silent) ischaemia on left ventricular systolic function in stable angina - Clinical and radionuclide study, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 1342-1347, ISSN: 0195-668X

Journal article

Fox KM, Henderson JR, Bertrand ME, Ferrari R, Remme WJ, Simoons MLet al., 1998, The European trial on reduction of cardiac events with perindopril in stable coronary artery disease (EUROPA), EUROPEAN HEART JOURNAL, Vol: 19, Pages: J52-J55, ISSN: 0195-668X

Journal article

Knight CJ, Panesar M, Wilson DJ, Patrineli A, Chronos N, Wright C, Clarke D, Patel D, Fox K, Goodall AHet al., 1998, Increased platelet responsiveness following coronary stenting - Heparin as a possible aetiological factor in stent thrombosis, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 1239-1248, ISSN: 0195-668X

Journal article

Curzen NP, Patel DJ, Kemp M, Hooper J, Knight CJ, Clarke D, Wright C, Fox KMet al., 1998, Can C reactive protein or troponins T and I predict outcome in patients with intractable unstable angina?, HEART, Vol: 80, Pages: 23-27, ISSN: 1355-6037

Journal article

Curzen N, Fox K, 1998, Women and myocardial infarction, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 980-981, ISSN: 0195-668X

Journal article

Gunning MG, Kaprielian RR, Pepper J, Pennell DJ, Fox K, Sheppard MN, Severs NJ, Underwood SRet al., 1998, Histology of hibernating myocardium characterised by Tl-201 imaging and dobutamine cine MRI, Heart, Vol: 79, ISSN: 1355-6037

Aim: To characterise the histology of hibernating myocardium based on pre-operative imaging features and post-operative functional recovery. Methods: We studied 21 patients with impaired left ventricular function scheduled for CABG. All underwent stress and separate day rest Tl-201 scintigraphy, and low-dose dobutamine MRI pre-operatively. At CABG transmural biopsies were taken from up to 4 myocardial segments per patient. Follow-up rest MRI was conducted after 3-6 months. Significantly hypocontractile segments of myocardium (on pre-op MRI) were evaluated for response to dobutamine, reversible ischaemia, rest Tl-201 uptake and functional recovery. Segments were classified as hibernating if wall motion improved by ≥1 grade following CABG. Biopsy specimens were assessed for % connective tissue content(CT), degree of glycogen accumulation(GLY), and degree of myocyte loss(ML). Results: Comparing hibernating and non-hibernating segments(scar), mean CT was 29.3±15.8% vs 38.1±23.7%(p=ns), mean GLY was 1.1±1 vs 1.5±0.9(p=ns), and mean ML was 1.4±1.2 vs 1.2±0.9(p=ns) respectively. On pre-operative MRI, comparing segments which responded to dobutamine to those that did not, CT was 23.1±7.2 vs 35.3±21.3%(p<0.05), GLY was 1.2±0.8 vs 1.2±1(p=ns) and ML was 1.7±1 vs 1.3±1.1(p=ns) respectively. For segments with Tl-201 uptake ≥60% vs uptake <60%, CT was 28.4±16 vs 36.4±22.7%(p=ns). Comparing ischaemic vs non-ischaemic segments CT was 30.8±18.1 vs 32.1±19.7%, GLY was 1.1±1 vs 1.3±1.1(p=ns), and ML was 1.4±1.2 vs 1.2±1.1(p=ns) respectively. Conclusions: Regions of myocardium displaying inotropic repense to dobutamine contain significantly less fibrous tissue than non-responsive regions. Hibernating myocardium contains less fibrous tissue than scar but the difference is not significant. Glycogen accumulation and myocyte loss do not de

Journal article

Young VK, Mac Kinnon A, Fox K, Davies S, Moat Net al., 1998, The management of intractable angina - A role for transmyocardial laser revascularisation, Heart, Vol: 79, ISSN: 1355-6037

Transmyocardial Laser Revascularisation (TMLR) offers a novel solution to the relief of intractable angina for patients not suitable for therapies already of proven benefit. To date, 44 patients have been referred to our institution for consideration for TMLR. Of the 44 patients referred, 41 were male and the median age was 62 years. All of patients had had previous myocardial revascularisation (79% one episode of CABG, 21% two or more episodes of CABG's, in addition to 38% having PTCA). The management algorithm assigned patients to one of 4 treatment groups: 1. Medical therapy: -16 patients were unsuitable for repeat revascularisation or TMLR and had continuing medical therapy. Three of these patients had no demonstrable reversible ischaemia on thallium, in 9 patients the risks of operation were considered to be prohibitive, while 2 were asymptomatic. Two patients who were offered TMLR declined. 2. PTCA: -3 patients were judged suitable for PTCA and these were carried out without complication. All 3 PTCA's included angioplasty to previous grafts. 3. Redo surgery: -11 patients were judged suitable for repeat surgical revascularisation. These were carried out with no operative deaths and all reported relief of angina. 4. TMLR: -14 patients showed reversible ischaemia and were not suitable for conventional revascularisation and therefore had TMLR. The median age of these patients was 62 and 13 were male. The mean ejection fraction was 49%. All 14 of these patients had previous CABG and 4 had had 2 or more previous CABG's. One patient required IABP and the mean lengths of stay in ITU and hospital respectively were 2 and 8 days. There were no perioperative deaths and at a median follow up of 3 months all were alive. Sixty percent had improvement in angina of at least one Canadian cardiac score grade. Conclusions: Patients referred for TMLR are a complex and heterogeneous group. TMLR can be performed with low mortality in a highly selected group. However, many of these p

Journal article

Chua TP, Howling SJ, Wright C, Fox KMet al., 1998, Ultrasound-guided compression of femoral pseudoaneurysm: an audit of practice, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 63, Pages: 245-250, ISSN: 0167-5273

Journal article

Kaprielian RR, Gunning M, Dupont E, Sheppard MN, Rothery SM, Underwood R, Pennell DJ, Fox K, Pepper J, Poole-Wilson PA, Severs NJet al., 1998, Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle, CIRCULATION, Vol: 97, Pages: 651-660, ISSN: 0009-7322

Journal article

Bowker T, Turner R, Gandhi M, Roberts T, Curzen N, Thompson S, Fox K, Wood Det al., 1998, A UK national survey of in-hospital complications and management of acute myocardial ischaemia & infarction, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 393A-394A, ISSN: 0735-1097

Journal article

Bowker T, Turner R, Roberts T, Curzen N, Gandhi M, Thompson S, Fox K, Wood Det al., 1998, Is the occurrence, management and outcome of acute myocardial ischaemia & infarction gender dependent?: A UK national survey, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 31, Pages: 524A-524A, ISSN: 0735-1097

Journal article

Patel DJ, Knight CJ, Holdright DR, Mulcahy D, Clarke D, Wright C, Purcell H, Fox KMet al., 1998, Long-term prognosis in unstable angina - The importance of early risk stratification using continuous ST segment monitoring, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 240-249, ISSN: 0195-668X

Journal article

Knight CJ, Fox KM, 1998, Amlodipine versus diltiazem as additional antianginal treatment to atenolol. Centralised European Studies in Angina Research (CESAR) Investigators., Am J Cardiol, Vol: 81, Pages: 133-136, ISSN: 0002-9149

The antianginal efficacy and tolerability of amlodipine and diltiazem were compared in a double-blind randomized trial of 97 patients with angina resistant to atenolol alone. Both amlodipine and diltiazem significantly reduced the frequency of angina attacks (p <0.001) and glyceryl trinitrate consumption (p <0.05 to p <0.01). During Holter monitoring, both treatments reduced the overall frequency of ambulatory myocardial ischemia, although changes did not reach statistical significance. Exercise test parameters (total exercise time, time to angina, time to ST depression, and maximum ST depression) tended to improve with both treatments, but changes did not achieve statistical significance relative to baseline or to each other. Both drugs were generally well tolerated. Adverse events occurred in 15 patients in the amlodipine group (30%) and in 17 patients in the diltiazem group (36%), but patients taking diltiazem reported almost twice as many adverse events (30) patients taking amlodipine (18). Quality of life, as assessed by total Nottingham Health Profile Scores, was not significantly different between treatments. The addition of either once-daily amlodipine or twice-daily sustained release diltiazem improved symptoms in patients with angina resistant to atenolol alone, but diltiazem was associated with more frequent and more serious adverse events.

Journal article

Knight CJ, Fox KM, 1998, <i>Amlodipine</i> versus <i>diltiazem</i> as additional antianginal treatment to <i>atenolol</i>, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 81, Pages: 133-136, ISSN: 0002-9149

Journal article

Knight CJ, Curzen N, Groves PH, Patel DJ, Goodall AH, Wright C, Clarke D, Oldershaw PJ, Fox KMet al., 1997, Stenting suboptimal results following balloon angioplasty significantly reduces restenosis: Results of a single centre randomised trial, CIRCULATION, Vol: 96, Pages: 3976-3976, ISSN: 0009-7322

Journal article

Patel DJ, Purcell H, Wright C, Clarke D, Fox KMet al., 1997, Nicorandil reduces myocardial ischemia and tachyarrhythmias in unstable angina: Results of a randomised placebo controlled multicentre study, CIRCULATION, Vol: 96, Pages: 3332-3332, ISSN: 0009-7322

Journal article

Knight CJ, Panesar M, Wright C, Clarke D, Butowski PS, Patel D, Patrineli A, Fox K, Goodall AHet al., 1997, Altered platelet function detected by flow cytometry - Effects of coronary artery disease and age, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 17, Pages: 2044-2053, ISSN: 1079-5642

Journal article

Curzen NP, Fox KM, 1997, Do ACE inhibitors modulate atherosclerosis?, EUROPEAN HEART JOURNAL, Vol: 18, Pages: 1530-1535, ISSN: 0195-668X

Journal article

Curzen N, Brett S, Fox K, 1997, Concrete induced cardiac contusion, HEART, Vol: 78, Pages: 313-315, ISSN: 1355-6037

Journal article

Gunning MG, Chua TP, Harrington D, Knight CJ, Burman E, Pennell DJ, Pepper J, Fox K, Underwood SRet al., 1997, Hibernating myocardium: Clinical and functional response to revascularisation, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 11, Pages: 1105-1112, ISSN: 1010-7940

Journal article

Patel DJ, Knight CJ, Holdright DR, Mulcahy D, Clarke D, Wright C, Purcell H, Fox KMet al., 1997, Pathophysiology of transient myocardial ischemia in acute coronary syndromes - Characterization by continuous ST-segment monitoring, CIRCULATION, Vol: 95, Pages: 1185-1192, ISSN: 0009-7322

Journal article

Henein MY, Patel DJ, Fox KM, Gibson DGet al., 1997, Asynchronous left ventricular wall motion in unstable angina, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 59, Pages: 37-45, ISSN: 0167-5273

Journal article

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