Imperial College London
Alternate

Emeritus ProfessorKimFox

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 7966kim.fox

 
 
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Assistant

 

Ms Deborah Curcher +44 (0)20 7594 7966

 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vidal-Petiot:2018:eurheartj/ehy488,
author = {Vidal-Petiot, E and Sorbets, E and Bhatt, DL and Ducrocq, G and Elbez, Y and Ferrari, R and Ford, I and Tardif, J-C and Tendera, M and Fox, KM and Steg, PG and CLARIFY, investigators},
doi = {eurheartj/ehy488},
journal = {European Heart Journal},
pages = {3855--3863},
title = {Potential impact of the 2017 ACC/AHA guideline on high blood pressure in normotensive patients with stable coronary artery disease: insights from the CLARIFY registry},
url = {http://dx.doi.org/10.1093/eurheartj/ehy488},
volume = {39},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aims: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline on high blood pressure (BP) lowered the threshold defining hypertension and BP target in high-risk patients to 130/80 mmHg. Patients with coronary artery disease and systolic BP 130-139 mmHg or diastolic BP 80-89 mmHg should now receive medication to achieve this target. We aimed to investigate the relationship between BP and cardiovascular events in 'real-life' patients with coronary artery disease considered as having normal BP until the recent guideline. Methods and results: Data from 5956 patients with stable coronary artery disease, no history of hypertension or heart failure, and average BP <140/90 mmHg, enrolled in the CLARIFY registry (November 2009 to June 2010), were analysed. In a multivariable-adjusted Cox proportional hazards model, after a median follow-up of 5.0 years, diastolic BP 80-89 mmHg, but not systolic BP 130-139 mmHg, was associated with increased risk of the primary endpoint, a composite of cardiovascular death, myocardial infarction, or stroke (hazard ratio 2.15, 95% confidence interval 1.22-3.81 vs. 70-79 mmHg and 1.12, 0.64-1.97 vs. 120-129 mmHg). No significant increase in risk for the primary endpoint was observed for systolic BP <120 mmHg or diastolic BP <70 mmHg. Conclusion: In patients with stable coronary artery disease defined as having normal BP according to the 140/90 mmHg threshold, diastolic BP 80-89 mmHg was associated with increased cardiovascular risk, whereas systolic BP 130-139 mmHg was not, supporting the lower diastolic but not the lower systolic BP hypertension-defining threshold and treatment target in coronary artery disease. ClinicalTrials identifier: ISRCTN43070564.
AU  - Vidal-Petiot,E
AU  - Sorbets,E
AU  - Bhatt,DL
AU  - Ducrocq,G
AU  - Elbez,Y
AU  - Ferrari,R
AU  - Ford,I
AU  - Tardif,J-C
AU  - Tendera,M
AU  - Fox,KM
AU  - Steg,PG
AU  - CLARIFY,investigators
DO  - eurheartj/ehy488
EP  - 3863
PY  - 2018///
SN  - 1522-9645
SP  - 3855
TI  - Potential impact of the 2017 ACC/AHA guideline on high blood pressure in normotensive patients with stable coronary artery disease: insights from the CLARIFY registry
T2  - European Heart Journal
UR  - http://dx.doi.org/10.1093/eurheartj/ehy488
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30124796
UR  - http://hdl.handle.net/10044/1/63618
VL  - 39
ER  -
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