Imperial College London
Alternate

ProfessorLucaMagnani

Faculty of Medicine, Department of Surgery & Cancer

Honorary Principal Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2808l.magnani CV

 
 
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Location

 

137ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ciriello:2024:10.1158/2159-8290.CD-23-0530,
author = {Ciriello, G and Magnani, L and Aitken, SJ and Akkari, L and Behjati, S and Hanahan, D and Landau, DA and Lopez-Bigas, N and Lupiáñez, DG and Marine, J-C and Martin-Villalba, A and Natoli, G and Obenauf, AC and Oricchio, E and Scaffidi, P and Sottoriva, A and Swarbrick, A and Tonon, G and Vanharanta, S and Zuber, J},
doi = {10.1158/2159-8290.CD-23-0530},
journal = {Cancer Discov},
pages = {36--48},
title = {Cancer Evolution: A Multifaceted Affair.},
url = {http://dx.doi.org/10.1158/2159-8290.CD-23-0530},
volume = {14},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - UNLABELLED: Cancer cells adapt and survive through the acquisition and selection of molecular modifications. This process defines cancer evolution. Building on a theoretical framework based on heritable genetic changes has provided insights into the mechanisms supporting cancer evolution. However, cancer hallmarks also emerge via heritable nongenetic mechanisms, including epigenetic and chromatin topological changes, and interactions between tumor cells and the tumor microenvironment. Recent findings on tumor evolutionary mechanisms draw a multifaceted picture where heterogeneous forces interact and influence each other while shaping tumor progression. A comprehensive characterization of the cancer evolutionary toolkit is required to improve personalized medicine and biomarker discovery. SIGNIFICANCE: Tumor evolution is fueled by multiple enabling mechanisms. Importantly, genetic instability, epigenetic reprogramming, and interactions with the tumor microenvironment are neither alternative nor independent evolutionary mechanisms. As demonstrated by findings highlighted in this perspective, experimental and theoretical approaches must account for multiple evolutionary mechanisms and their interactions to ultimately understand, predict, and steer tumor evolution.
AU  - Ciriello,G
AU  - Magnani,L
AU  - Aitken,SJ
AU  - Akkari,L
AU  - Behjati,S
AU  - Hanahan,D
AU  - Landau,DA
AU  - Lopez-Bigas,N
AU  - Lupiáñez,DG
AU  - Marine,J-C
AU  - Martin-Villalba,A
AU  - Natoli,G
AU  - Obenauf,AC
AU  - Oricchio,E
AU  - Scaffidi,P
AU  - Sottoriva,A
AU  - Swarbrick,A
AU  - Tonon,G
AU  - Vanharanta,S
AU  - Zuber,J
DO  - 10.1158/2159-8290.CD-23-0530
EP  - 48
PY  - 2024///
SP  - 36
TI  - Cancer Evolution: A Multifaceted Affair.
T2  - Cancer Discov
UR  - http://dx.doi.org/10.1158/2159-8290.CD-23-0530
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38047596
VL  - 14
ER  -
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