Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mutono:2024:10.1016/S2214-109X(24)00043-3,
author = {Mutono, N and Basáñez, M-G and James, A and Stolk, WA and Makori, A and Kimani, TN and Hollingsworth, TD and Vasconcelos, A and Dixon, MA and de, Vlas SJ and Thumbi, SM},
doi = {10.1016/S2214-109X(24)00043-3},
journal = {The Lancet Global Health},
pages = {e771--e782},
title = {Elimination of transmission of onchocerciasis (river blindness) with long-term ivermectin mass drug administration with or without vector control in sub-Saharan Africa: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1016/S2214-109X(24)00043-3},
volume = {12},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: WHO has proposed elimination of transmission of onchocerciasis (river blindness) by 2030. More than 99% of cases of onchocerciasis are in sub-Saharan Africa. Vector control and mass drug administration of ivermectin have been the main interventions for many years, with varying success. We aimed to identify factors associated with elimination of onchocerciasis transmission in sub-Saharan Africa. METHODS: For this systematic review and meta-analysis we searched for published articles reporting epidemiological or entomological assessments of onchocerciasis transmission status in sub-Saharan Africa, with or without vector control. We searched MEDLINE, PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, African Index Medicus, and Google Scholar databases for all articles published from database inception to Aug 19, 2023, without language restrictions. The search terms used were "onchocerciasis" AND "ivermectin" AND "mass drug administration". The three inclusion criteria were (1) focus or foci located in Africa, (2) reporting of elimination of transmission or at least 10 years of ivermectin mass drug administration in the focus or foci, and (3) inclusion of at least one of the following assessments: microfilarial prevalence, nodule prevalence, Ov16 antibody seroprevalence, and blackfly infectivity prevalence. Epidemiological modelling studies and reviews were excluded. Four reviewers (NM, AJ, AM, and TNK) extracted data in duplicate from the full-text articles using a data extraction tool developed in Excel with columns recording the data of interest to be extracted, and a column where important comments for each study could be highlighted. We did not request any individual-level data from authors. Foci were classified as achieving elimination of transmission, being close to elimination of transmission, or with ongoing transmission. We used mixed-effects meta-regression models to identify factors assoc
AU  - Mutono,N
AU  - Basáñez,M-G
AU  - James,A
AU  - Stolk,WA
AU  - Makori,A
AU  - Kimani,TN
AU  - Hollingsworth,TD
AU  - Vasconcelos,A
AU  - Dixon,MA
AU  - de,Vlas SJ
AU  - Thumbi,SM
DO  - 10.1016/S2214-109X(24)00043-3
EP  - 782
PY  - 2024///
SN  - 2214-109X
SP  - 771
TI  - Elimination of transmission of onchocerciasis (river blindness) with long-term ivermectin mass drug administration with or without vector control in sub-Saharan Africa: a systematic review and meta-analysis
T2  - The Lancet Global Health
UR  - http://dx.doi.org/10.1016/S2214-109X(24)00043-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38484745
UR  - http://hdl.handle.net/10044/1/110795
VL  - 12
ER  -
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