Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Walker:2016:10.1186/s13071-016-1312-0,
author = {Walker, M and Mabud, T and Olliaro, PL and Coulibaly, JT and King, CH and Raso, G and Scherrer, AU and Stothard, JR and Sousa-Figueiredo, JC and Stete, K and Utzinger, J and Basanez, MG},
doi = {10.1186/s13071-016-1312-0},
journal = {Parasites & Vectors},
title = {New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel},
url = {http://dx.doi.org/10.1186/s13071-016-1312-0},
volume = {9},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND:By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics. Quantitative monitoring of anthelminthic responses is crucial for promptly detecting changes in efficacy, potentially indicative of emerging drug resistance. Statistical models offer a powerful means to delineate and compare efficacy among individuals, among groups of individuals and among populations.METHODS:We illustrate a variety of statistical frameworks that offer different levels of inference by analysing data from nine previous studies on egg counts collected from African children before and after administration of praziquantel.RESULTS:We quantify responses to praziquantel as egg reduction rates (ERRs), using different frameworks to estimate ERRs among population strata, as average responses, and within strata, as individual responses. We compare our model-based average ERRs to corresponding model-free estimates, using as reference the World Health Organization (WHO) 90 % threshold of optimal efficacy. We estimate distributions of individual responses and summarize the variation among these responses as the fraction of ERRs falling below the WHO threshold.CONCLUSIONS:Generic models for evaluating responses to anthelminthics deepen our understanding of variation among populations, sub-populations and individuals. We discuss the future application of statistical modelling approaches for monitoring and evaluation of PCT programmes targeting human helminthiases in the context of the WHO 2020 control and elimination goals.
AU  - Walker,M
AU  - Mabud,T
AU  - Olliaro,PL
AU  - Coulibaly,JT
AU  - King,CH
AU  - Raso,G
AU  - Scherrer,AU
AU  - Stothard,JR
AU  - Sousa-Figueiredo,JC
AU  - Stete,K
AU  - Utzinger,J
AU  - Basanez,MG
DO  - 10.1186/s13071-016-1312-0
PY  - 2016///
SN  - 1756-3305
TI  - New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel
T2  - Parasites & Vectors
UR  - http://dx.doi.org/10.1186/s13071-016-1312-0
UR  - http://hdl.handle.net/10044/1/30262
VL  - 9
ER  -
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