Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Winskill:2017:10.1186/s13071-017-1988-9,
author = {Winskill, P and Harrison, W and French, M and Dixon, M and Abela-Ridder, B and Basanez, MG},
doi = {10.1186/s13071-017-1988-9},
journal = {Parasites & Vectors},
title = {Assessing the impact of intervention strategies against Taenia solium cysticercosis using the EPICYST transmission model},
url = {http://dx.doi.org/10.1186/s13071-017-1988-9},
volume = {10},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organization (WHO) has set goals for having a validated strategy for control and elimination of T. solium taeniasis/cysticercosis by 2015 and interventions scaled-up in selected countries by 2020. Timely achievement of these internationally-endorsed targets requires that the relative benefits and effectiveness of potential interventions be explored rigorously within a quantitative framework.MethodsA deterministic, compartmental transmission model (EPICYST) was developed to capture the dynamics of the taeniasis/cysticercosis disease system in the human and pig hosts. Cysticercosis prevalence in humans, an outcome of high epidemiological and clinical importance, was explicitly modelled. A next generation matrix approach was used to derive an expression for the basic reproduction number, R 0. A full sensitivity analysis was performed using a methodology based on Latin-hypercube sampling partial rank correlation coefficient index.ResultsEPICYST outputs indicate that chemotherapeutic intervention targeted at humans or pigs would be highly effective at reducing taeniasis and cysticercosis prevalence when applied singly, with annual chemotherapy of humans and pigs resulting, respectively, in 94 and 74% of human cysticercosis cases averted. Improved sanitation, meat inspection and animal husbandry are less effective but are still able to reduce prevalence singly or in combination. The value of R 0 for taeniasis was estimated at 1.4 (95% Credible Interval: 0.5–3.6).ConclusionsHuman- and pig-targeted drug-focussed interventions appear to be the most efficacious approach from the options currently available. The model presented is a forward step towards developing an informed control and elimination strategy for cysticercosis. Together with its validation agai
AU  - Winskill,P
AU  - Harrison,W
AU  - French,M
AU  - Dixon,M
AU  - Abela-Ridder,B
AU  - Basanez,MG
DO  - 10.1186/s13071-017-1988-9
PY  - 2017///
SN  - 1756-3305
TI  - Assessing the impact of intervention strategies against Taenia solium cysticercosis using the EPICYST transmission model
T2  - Parasites & Vectors
UR  - http://dx.doi.org/10.1186/s13071-017-1988-9
UR  - http://hdl.handle.net/10044/1/44138
VL  - 10
ER  -
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