Imperial College London
Alternate

ProfessorMartaBlangiardo

Faculty of Medicine, School of Public Health

Chair in Biostatistics
 
 
 
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Contact

 

m.blangiardo Website

 
 
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Location

 

705School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2023:10.1016/j.envint.2023.107765,
author = {Li, G and Denise, H and Diggle, P and Grimsley, J and Holmes, C and James, D and Jersakova, R and Mole, C and Nicholson, G and Rangel, Smith C and Richardson, S and Rowe, W and Rowlingson, Visualisation B and Torabi, F and Wade, MJ and Blangiardo, M},
doi = {10.1016/j.envint.2023.107765},
journal = {Environment International},
pages = {1--10},
title = {A spatio-temporal framework for modelling wastewater concentration during the COVID-19 pandemic},
url = {http://dx.doi.org/10.1016/j.envint.2023.107765},
volume = {172},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The potential utility of wastewater-based epidemiology as an early warning tool has been explored widely across the globe during the current COVID-19 pandemic. Methods to detect the presence of SARS-CoV-2 RNA in wastewater were developed early in the pandemic, and extensive work has been conducted to evaluate the relationship between viral concentration and COVID-19 case numbers at the catchment areas of sewage treatment works (STWs) over time. However, no attempt has been made to develop a model that predicts wastewater concentration at fine spatio-temporal resolutions covering an entire country, a necessary step towards using wastewater monitoring for the early detection of local outbreaks.We consider weekly averages of flow-normalised viral concentration, reported as the number of SARS-CoV-2N1 gene copies per litre (gc/L) of wastewater available at 303 STWs over the period between 1 June 2021 and 30 March 2022. We specify a spatially continuous statistical model that quantifies the relationship between weekly viral concentration and a collection of covariates covering socio-demographics, land cover and virus associated genomic characteristics at STW catchment areas while accounting for spatial and temporal correlation.We evaluate the model’s predictive performance at the catchment level through 10-fold cross-validation. We predict the weekly viral concentration at the population-weighted centroid of the 32,844 lower super output areas (LSOAs) in England, then aggregate these LSOA predictions to the Lower Tier Local Authority level (LTLA), a geography that is more relevant to public health policy-making. We also use the model outputs to quantify the probability of local changes of direction (increases or decreases) in viral concentration over short periods (e.g. two consecutive weeks).The proposed statistical framework can predict SARS-CoV-2 viral concentration in wastewater at high spatio-temporal resolution across England. Additionally, the probabilistic q
AU  - Li,G
AU  - Denise,H
AU  - Diggle,P
AU  - Grimsley,J
AU  - Holmes,C
AU  - James,D
AU  - Jersakova,R
AU  - Mole,C
AU  - Nicholson,G
AU  - Rangel,Smith C
AU  - Richardson,S
AU  - Rowe,W
AU  - Rowlingson,Visualisation B
AU  - Torabi,F
AU  - Wade,MJ
AU  - Blangiardo,M
DO  - 10.1016/j.envint.2023.107765
EP  - 10
PY  - 2023///
SN  - 0160-4120
SP  - 1
TI  - A spatio-temporal framework for modelling wastewater concentration during the COVID-19 pandemic
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2023.107765
UR  - https://www.sciencedirect.com/science/article/pii/S0160412023000387?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101880
VL  - 172
ER  -
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