Imperial College London
Alternate

Prof Marc Chadeau-Hyam

Faculty of Medicine, School of Public Health

Professor of Computational Epidemiology and Biostatistics
 
 
 
//

Contact

 

+44 (0)20 7594 1637m.chadeau

 
 
//

Location

 

520Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Fiorito:2017:10.1038/s41598-017-16391-5,
author = {Fiorito, G and Polidoro, S and Dugue, P-A and Kivimaki, M and Ponzi, E and Matullo, G and Guarrera, S and Assumma, MB and Georgiadis, P and Kyrtopoulos, SA and Krogh, V and Palli, D and Panico, S and Sacerdote, C and Tumino, R and Chadeau-Hyam, M and Stringhini, S and Severi, G and Hodge, AM and Giles, GG and Marioni, R and Linner, RK and O'Halloran, AM and Kenny, RA and Layte, R and Baglietto, L and Robinson, O and McCrory, C and Milne, RL and Vineis, P},
doi = {10.1038/s41598-017-16391-5},
journal = {Scientific Reports},
title = {Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation},
url = {http://dx.doi.org/10.1038/s41598-017-16391-5},
volume = {7},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.
AU  - Fiorito,G
AU  - Polidoro,S
AU  - Dugue,P-A
AU  - Kivimaki,M
AU  - Ponzi,E
AU  - Matullo,G
AU  - Guarrera,S
AU  - Assumma,MB
AU  - Georgiadis,P
AU  - Kyrtopoulos,SA
AU  - Krogh,V
AU  - Palli,D
AU  - Panico,S
AU  - Sacerdote,C
AU  - Tumino,R
AU  - Chadeau-Hyam,M
AU  - Stringhini,S
AU  - Severi,G
AU  - Hodge,AM
AU  - Giles,GG
AU  - Marioni,R
AU  - Linner,RK
AU  - O'Halloran,AM
AU  - Kenny,RA
AU  - Layte,R
AU  - Baglietto,L
AU  - Robinson,O
AU  - McCrory,C
AU  - Milne,RL
AU  - Vineis,P
DO  - 10.1038/s41598-017-16391-5
PY  - 2017///
SN  - 2045-2322
TI  - Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-16391-5
UR  - http://hdl.handle.net/10044/1/61088
VL  - 7
ER  -
Download