Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Akingbuwa:2020:10.1001/jamapsychiatry.2020.0527,
author = {Akingbuwa, WA and Hammerschlag, AR and Jami, ES and Allegrini, AG and Karhunen, V and Sallis, H and Ask, H and Askeland, RB and Baselmans, B and Diemer, E and Hagenbeek, FA and Havdahl, A and Hottenga, J-J and Mbarek, H and Rivadeneira, F and Tesli, M and van, Beijsterveldt C and Breen, G and Lewis, CM and Thapar, A and Boomsma, DI and Kuja-Halkola, R and Reichborn-Kjennerud, T and Magnus, P and Rimfeld, K and Ystrom, E and Jarvelin, M-R and Lichtenstein, P and Lundstrom, S and Munafo, MR and Plomin, R and Tiemeier, H and Nivard, MG and Bartels, M and Middeldorp, CM},
doi = {10.1001/jamapsychiatry.2020.0527},
journal = {JAMA Psychiatry},
pages = {715--728},
title = {Genetic associations between childhood psychopathology and adult depression and associated traits in 42998 individuals a meta-analysis},
url = {http://dx.doi.org/10.1001/jamapsychiatry.2020.0527},
volume = {77},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance  Adult mood disorders are often preceded by behavioral and emotional problems in childhood. It is yet unclear what explains the associations between childhood psychopathology and adult traits.Objective  To investigate whether genetic risk for adult mood disorders and associated traits is associated with childhood disorders.Design, Setting, and Participants  This meta-analysis examined data from 7 ongoing longitudinal birth and childhood cohorts from the UK, the Netherlands, Sweden, Norway, and Finland. Starting points of data collection ranged from July 1985 to April 2002. Participants were repeatedly assessed for childhood psychopathology from ages 6 to 17 years. Data analysis occurred from September 2017 to May 2019.Exposures  Individual polygenic scores (PGS) were constructed in children based on genome-wide association studies of adult major depression, bipolar disorder, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index (BMI).Main Outcomes and Measures  Regression meta-analyses were used to test associations between PGS and attention-deficit/hyperactivity disorder (ADHD) symptoms and internalizing and social problems measured repeatedly across childhood and adolescence and whether these associations depended on childhood phenotype, age, and rater.Results  The sample included 42998 participants aged 6 to 17 years. Male participants varied from 43.0% (1040 of 2417 participants) to 53.1% (2434 of 4583 participants) by age and across all cohorts. The PGS of adult major depression, neuroticism, BMI, and insomnia were positively associated with childhood psychopathology (β estimate range, 0.023-0.042 [95% CI, 0.017–0.049]), while associations with PGS of subjective well-being and educational attainment were negative (β, −0.026 to −0.046 [95% CI, −0.020 to −0.057]). There was no moderation of age, type of childhood phenotype, or rater with the associations. The exceptions were s
AU  - Akingbuwa,WA
AU  - Hammerschlag,AR
AU  - Jami,ES
AU  - Allegrini,AG
AU  - Karhunen,V
AU  - Sallis,H
AU  - Ask,H
AU  - Askeland,RB
AU  - Baselmans,B
AU  - Diemer,E
AU  - Hagenbeek,FA
AU  - Havdahl,A
AU  - Hottenga,J-J
AU  - Mbarek,H
AU  - Rivadeneira,F
AU  - Tesli,M
AU  - van,Beijsterveldt C
AU  - Breen,G
AU  - Lewis,CM
AU  - Thapar,A
AU  - Boomsma,DI
AU  - Kuja-Halkola,R
AU  - Reichborn-Kjennerud,T
AU  - Magnus,P
AU  - Rimfeld,K
AU  - Ystrom,E
AU  - Jarvelin,M-R
AU  - Lichtenstein,P
AU  - Lundstrom,S
AU  - Munafo,MR
AU  - Plomin,R
AU  - Tiemeier,H
AU  - Nivard,MG
AU  - Bartels,M
AU  - Middeldorp,CM
DO  - 10.1001/jamapsychiatry.2020.0527
EP  - 728
PY  - 2020///
SN  - 2168-622X
SP  - 715
TI  - Genetic associations between childhood psychopathology and adult depression and associated traits in 42998 individuals a meta-analysis
T2  - JAMA Psychiatry
UR  - http://dx.doi.org/10.1001/jamapsychiatry.2020.0527
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000549879400012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2763801
UR  - http://hdl.handle.net/10044/1/85675
VL  - 77
ER  -
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